LL-37, human acetate

LL-37, human acetate; 纯度: 99.50%

LL-37, human acetate 是一种具有 37 个残基的两亲性组织蛋白酶衍生的抗菌肽,具有广泛的抗菌活性。LL-37, human acetate 有助于保护角膜免受感染,调节伤口愈合。

LL-37, human acetateamp;;

LL-37, human acetate Chemical Structure

规格 价格 是否有货 数量
1 mg ¥1250 In-stock
5 mg ¥2600 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

LL-37, human acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity[1]. LL-37, human acetate could help protect the cornea from infection and modulates wound healing[2].

分子量

4553.31

Formula

C207H344N60O55

Sequence Shortening

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro:;

H2O : 100 mg/mL (21.96 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2196 mL 1.0981 mL 2.1962 mL
5 mM 0.0439 mL 0.2196 mL 0.4392 mL
10 mM 0.0220 mL 0.1098 mL 0.2196 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Dürr UH, et al. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta. 2006 Sep;1758(9):1408-25.

    [2]. Huang LC, et al. Multifunctional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2369-80.

LL-37 scrambled peptide acetate

LL-37 scrambled peptide acetate; 纯度: 98.42%

LL-37 scrambled peptide acetate 是导管素抗菌肽 LL-37 的乱序重排肽,可用作 LL-37 肽研究的阴性对照。

LL-37 scrambled peptide acetateamp;;

LL-37 scrambled peptide acetate Chemical Structure

规格 价格 是否有货 数量
5 mg ¥9600 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

LL-37 scrambled peptide acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

LL-37 scrambled peptide acetate is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide acetate can be used as a negative control of LL-37 peptide studies.

分子量

4553.35

Formula

C2H4O2

Sequence

Gly-Leu-Lys-Leu-Arg-Phe-Glu-Phe-Ser-Lys-Ile-Lys-Gly-Glu-Phe-Leu-Lys-Thr-Pro-Glu-Val-Arg-Phe-Arg-Asp-Ile-Lys-Leu-Lys-Asp-Asn-Arg-Ile-Ser-Val-Gln-Arg

Sequence Shortening

GLKLRFEFSKIKGEFLKTPEVRFRDIKLKDNRISVQR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Gerard Sheehan, et al. The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus. Infect Immun. 2018 Jun 21;86(7):e00097-18.

LL-37, acetylated,amidated

LL-37, acetylated,amidated;

LL-37, acetylated, amidated 是一种 N 末端乙酰化,C 末端酰胺化的组织蛋白酶肽 LL-37。人组织蛋白酶肽 LL-37 对多种革兰氏阳性和革兰氏阴性人体病原体具有抗菌和抗生物膜活性,对宿主有伤口愈合作用。

LL-37, acetylated,amidatedamp;;

LL-37, acetylated,amidated Chemical Structure

规格 是否有货
5 mg 询价
10 mg 询价

* Please select Quantity before adding items.

生物活性

LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host[1].

分子量

4534.40

Formula

C207H343N61O53

Sequence Shortening

Ac-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Duplantier AJ, et al. The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for PolymicrobialInfected Wounds. Front Immunol. 2013 Jul 3;4:143.

LL-37, human

LL-37, human;

LL-37, human 是一种具有 37 个残基的两亲性组织蛋白酶衍生的抗菌肽,具有广泛的抗菌活性。LL-37, human 有助于保护角膜免受感染,调节伤口愈合。

LL-37, humanamp;;

LL-37, human Chemical Structure

CAS No. : 154947-66-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

LL-37, human 的其他形式现货产品:

LL-37, human TFA LL-37, human acetate

生物活性

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity[1]. LL-37, human could help protect the cornea from infection and modulates wound healing[2].

分子量

4493.26

Formula

C205H340N60O53

CAS 号

154947-66-7

Sequence

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

Sequence Shortening

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dürr UH, et al. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta. 2006 Sep;1758(9):1408-25.

    [2]. Huang LC, et al. Multifunctional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2369-80.

LL-37, human TFA

LL-37, human TFA; 纯度: 99.71%

LL-37, human TFA 是一种具有 37 个残基的两亲性组织蛋白酶衍生的抗菌肽,具有广泛的抗菌活性。LL-37, human TFA 有助于保护角膜免受感染,调节伤口愈合。

LL-37, human TFAamp;;

LL-37, human TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥1250 In-stock
5 mg ¥2600 询价
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

LL-37, human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Antibacterial Compound Library
  • Peptide Library

生物活性

LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity[1]. LL-37, human TFA could help protect the cornea from infection and modulates wound healing[2].

分子量

4607.28

Formula

C205H340N60O53.C2HF3O2

Sequence

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

Sequence Shortening

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 100 mg/mL (21.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2170 mL 1.0852 mL 2.1705 mL
5 mM 0.0434 mL 0.2170 mL 0.4341 mL
10 mM 0.0217 mL 0.1085 mL 0.2170 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Dürr UH, et al. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta. 2006 Sep;1758(9):1408-25.

    [2]. Huang LC, et al. Multifunctional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2369-80.

LL-37 scrambled peptide

LL-37 scrambled peptide;

LL-37 scrambled peptide 是导管素抗菌肽 LL-37 的乱序重排肽,可用作 LL-37 肽研究的阴性对照。

LL-37 scrambled peptideamp;;

LL-37 scrambled peptide Chemical Structure

规格 价格 是否有货
500 μg ¥1600 询问价格 货期
1 mg ¥2600 询问价格 货期
5 mg ¥9600 询问价格 货期

* Please select Quantity before adding items.

LL-37 scrambled peptide 的其他形式现货产品:

LL-37 scrambled peptide acetate

生物活性

LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide can be used as a negative control of LL-37 peptide studies.

分子量

4493.30

Formula

C25H340N60O53

Sequence Shortening

GLKLRFEFSKIKGEFLKTPEVRFRDIKLKDNRISVQR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Gerard Sheehan, et al. The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus. Infect Immun. 2018 Jun 21;86(7):e00097-18.