Lipopolysaccharides(Synonyms: 脂多糖; LPS)

生化分析试剂 Biochemical Assay Reagents
Lipopolysaccharides;(Synonyms: 脂多糖; LPS)

Lipopolysaccharides (LPS) 脂多糖是从革兰氏阴性菌外膜的外叶中提取的内毒素,由一个抗原 O- 特异性链、一个核心寡糖和脂质 A 构成,是高度免疫原性抗原可以增强免疫反应。本产品来源于大肠杆菌 O55:B5。

Lipopolysaccharides(Synonyms: 脂多糖; LPS)

Lipopolysaccharides Chemical Structure

规格 价格 是否有货 数量
5 mg ¥1200 In-stock
10 mg ¥2000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Lipopolysaccharides 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Animal Disease Model Inducer Library

生物活性

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A[3]. Lipopolysaccharides is a highly immunogenic antigen which can enhance immune responses[4][5]. This product is derived from Escherichia coli O55:B5.

Clinical Trial

中文名称

脂多糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 5 mg/mL (Need ultrasonic)

参考文献
  • [1]. Rietschel ET, et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 1994 Feb;8(2):217-25.

    [2]. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404.

    [3]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32.

    [4]. Kajiwara Y, et al. A critical role for human caspase-4 in endotoxin sensitivity. J Immunol. 2014 Jul 1;193(1):335-43.

    [5]. Lai HT, et al. Effects of repeated intratracheally administered lipopolysaccharide on primary and secondary specific antibody responses and on body weight gain of broilers. Poult Sci. 2011 Feb;90(2):337-51.

Siegesbeckialide I

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Siegesbeckialide I 

Siegesbeckialide I 在 RAW264.7 细胞中通过直接结合 IKKα/β 有效地抑制 LPS 诱导的 NO 生成。

Siegesbeckialide I

Siegesbeckialide I Chemical Structure

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.

分子量

364.43

Formula

C20H28O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gao X, et al. Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β. J Nat Prod. 2021 Nov 26;84(11):2808-2821.

Methylsyringin

天然产物 天然产物苯丙素类 Phenylpropanoids

Methylsyringin 

Methylsyringin 在 LPS 刺激的 RAW264.7 细胞中显示出抗炎活性。

Methylsyringin

Methylsyringin Chemical Structure

CAS No. : 139742-20-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

分子量

386.39

Formula

C18H26O9

CAS 号

139742-20-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dong H, et al. Total Syntheses and Anti-inflammatory Activities of Syringin and Its Natural Analogues. J Nat Prod. 2021 Nov 26;84(11):2866-2874.

Ganoderterpene A

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ganoderterpene A 

Ganoderterpene A 通过抑制 BV-2 细胞中的 MAPK 和 TLR-4/NF-κB 途径减轻 LPS 诱导的炎症和凋亡。

Ganoderterpene A

Ganoderterpene A Chemical Structure

CAS No. : 2682180-85-2

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells.

分子量

530.69

Formula

C31H46O7

CAS 号

2682180-85-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kou RW, et al. Ganoderterpene A, a New Triterpenoid from Ganoderma lucidum, Attenuates LPS-Induced Inflammation and Apoptosis via Suppressing MAPK and TLR-4/NF-κB Pathways in BV-2 Cells. J Agric Food Chem. 2021 Nov 3;69(43):12730-12740.