Malantide; 纯度: 98.56%
Malantide 是一种合成的十二肽,由被磷酸化酶激酶β亚基上的 PKA 磷酸化的位点衍生而来。Malantide 是 PKA 的高度特异性底物,Km 为 15 μM,并且在各种大鼠组织提取物中显示出 PKI 抑制 > 90%底物磷酸化。Malantide 也是 PKC 的有效底物,Km 为 16 μM。
Malantide Chemical Structure
CAS No. : 86555-35-3
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1 mg | ¥800 | In-stock | |
5 mg | ¥1800 | In-stock | |
10 mg | ¥2800 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Malantide 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Kinase Inhibitor Library
- Protein Tyrosine Kinase Compound Library
- Stem Cell Signaling Compound Library
- TGF-beta/Smad Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Oxygen Sensing Compound Library
- Cytoskeleton Compound Library
- Peptide Library
生物活性 |
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts[1]. Malantide is also an efficient substrate for PKC with a Km of 16 μM[2]. |
IC50 Target |
Km: 15 μM (PKA)[1], 16 μM (PKC)[2], 233 μM (PKG)[1] |
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体外研究 (In Vitro) |
The Km values of Malantide are 15 μM and 223 μM for PKA and PKG, respectively. The Vmax values are 23.8 units/mg and 6.6 units/mg for for PKA and PKG, respectively[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1633.89 |
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Formula |
C72H124N22O21 |
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CAS 号 |
86555-35-3 |
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Sequence |
Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile |
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Sequence Shortening |
RTKRSGSVYEPLKI |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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