Manoalide 曼诺力得 品牌:FUJIFILM Wako


Manoalide

曼诺力得

品牌:FUJIFILM Wako
CAS No.:75088-80-1
储存条件:-20℃
纯度:98+% (TLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

131-10471

for Biochemistry 1mg 3,950.00


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Manoalide

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Manoalide 

Manoalide 是一种有效的磷脂酶 A2 (PLA2) 和磷脂酶 C (PLC) 抑制剂。Manoalide 是一种类萜化合物,具有抗炎和抗菌活性。

Manoalide

Manoalide Chemical Structure

CAS No. : 75088-80-1

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生物活性

Manoalide is a potent Phospholipase A2 (PLA2) and Phospholipase C (PLC) inhibitor. Manoalide, a sesterpenoid compound, displays anti-inflammatory and antibacterial activities[1][2][3].

IC50 & Target[1][2][3]

PLA2

 

PLC

 

体外研究
(In Vitro)

Manoalide (0.05 μM) impaires IL-7-induced entry of the B cell progenitors into S and G2/M phases and increases the population of apoptotic cells in IL-7-cultured B cell progenitors. In addition, Manoalide reduced IL-7-induced phosphorylation of S6 compared to the control without inhibitor pre-treatment[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Manoalide reverses venom preconditioning (VPC)-induced anti-inflammatory effects 24 h after surgical brain injury (SBI) in adult male Sprague-Dawley rats, 260 to 300 g[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

416.55

Formula

C25H36O5

CAS 号

75088-80-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mei Yu, et al. PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017 Nov 13;8(1):1457.

    [2]. Yuechun Wang, et al. Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation. Sci Rep. 2017 Jul 14;7(1):5466.

    [3]. Afef Dellai, et al. Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis. Cancer Cell Int. 2012 Apr 11;12(1):15.