Velutin

天然产物 黄酮类 Flavonoids

Velutin  纯度: ≥98.0%

Velutin 是从槲寄生中提取的苷元,具有抑制黑色素生物合成的活性。Velutin 能通过 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。

Velutin

Velutin Chemical Structure

CAS No. : 25739-41-7

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Velutin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
  • Natural Product Library
  • Phenols Library
  • Flavonoids Library

生物活性

Velutin is an aglycone extracted from Korean Mistletoe, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway[1][2].

分子量

314.29

Formula

C17H14O6

CAS 号

25739-41-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (159.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1818 mL 15.9089 mL 31.8177 mL
5 mM 0.6364 mL 3.1818 mL 6.3635 mL
10 mM 0.3182 mL 1.5909 mL 3.1818 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Jung SH, et al. Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis. Molecules. 2019 Jul 12;24(14).

    [2]. Brito C, et al. Cytotoxicity and potential anti-inflammatory activity of velutin on RAW 264.7 cell line differentiation: Implications in periodontal bone loss. Arch Oral Biol. 2017 Nov;83:348-356

Wulignan A1

天然产物 天然产物苯丙素类 Phenylpropanoids

Wulignan A1 

Wulignan A1 是从五味子的茎中提取出来的。Wulignan A1 表现出抗流感病毒 H1N1H1N1-TR (达菲流感病毒耐药株)的活性。

Wulignan A1

Wulignan A1 Chemical Structure

CAS No. : 117047-76-4

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生物活性

Wulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities[1].

IC50 & Target

IC50: H1N1; H1N1-TR[1]

分子量

342.39

Formula

C20H22O5

CAS 号

117047-76-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chang, Wen-liang, Schisandrae fructus extracts for inhibition or prevention of H1N1 influenza virus infection and its application thereof. US 8414938 B2[P]. 2013.

TNF-α (31-45), human TFA

TNF-α (31-45), human TFA; 纯度: 98.06%

TNF-α (31-45), human (TFA) 是人肿瘤坏死因子-α 的多肽片段。

TNF-α (31-45), human TFAamp;;

TNF-α (31-45), human TFA Chemical Structure

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TNF-alpha; (31-45), human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.

分子量

1781.89

Formula

C71H123F3N26O24

Sequence

Arg-Arg-Ala-Asn-Ala-Leu-Leu-Ala-Asn-Gly-Val-Glu-Leu-Arg-Asp

Sequence Shortening

RRANALLANGVELRD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

H2O : 33.33 mg/mL (18.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5612 mL 2.8060 mL 5.6120 mL
5 mM 0.1122 mL 0.5612 mL 1.1224 mL
10 mM 0.0561 mL 0.2806 mL 0.5612 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

Isorhoifolin(Synonyms: 异野漆树苷)

天然产物 黄酮类 Flavonoids

Isorhoifolin (Synonyms: 异野漆树苷) 纯度: 99.13%

Isorhoifolin 是 periploca nigrescens 叶片中的黄酮苷。Isorhoifolin 具有抗渗漏作用。

Isorhoifolin(Synonyms: 异野漆树苷)

Isorhoifolin Chemical Structure

CAS No. : 552-57-8

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Isorhoifolin 相关产品

相关化合物库:

  • Natural Product Library Plus
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  • Natural Product Library
  • Glycoside Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Food-Sourced Compound Library

生物活性

Isorhoifolin is a flavonoid glycoside from periploca nigrescens leaves. Isorhoifolin displays an anti-leakage effect[1][2].

分子量

578.52

Formula

C27H30O14

CAS 号

552-57-8

中文名称

异野漆树苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (172.85 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7285 mL 8.6427 mL 17.2855 mL
5 mM 0.3457 mL 1.7285 mL 3.4571 mL
10 mM 0.1729 mL 0.8643 mL 1.7285 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.32 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.32 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Ogundaini AO, et al. Isorhoifolin, a Flavonoid Glycoside from Periploca nigrescens Leaves.

    [2]. Paysant J, et al. Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation. Int Angiol. 2008 Feb;27(1):81-5.

Croverin

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Croverin 

Croverin 是一种从 Croton laui 的地上部分中分离出来的二萜化合物。

Croverin

Croverin Chemical Structure

CAS No. : 76475-17-7

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生物活性

Croverin is a diterpenoid compound isolated from the aerial parts of Croton laui[1].

分子量

370.40

Formula

C21H22O6

CAS 号

76475-17-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Liu CP, et al. Diterpenoids from Croton laui and their cytotoxic and antimicrobial activities. J Nat Prod. 2014;77(4):1013-1020

Epigomisin O

天然产物 天然产物苯丙素类 Phenylpropanoids

Epigomisin O 

Epigomisin O 是从五味子植物的果实中分离出来的。

Epigomisin O

Epigomisin O Chemical Structure

CAS No. : 73036-31-4

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生物活性

Epigomisin O is isolate from the fruits of Schisandra plants[1].

分子量

416.46

Formula

C23H28O7

CAS 号

73036-31-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chen M, et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.J Nat Prod. 2006 Dec;69(12):1697-701.

Icariside E5(Synonyms: 淫羊藿次甙E5)

天然产物 糖类和糖苷 Saccharides and Glycosides

Icariside E5;(Synonyms: 淫羊藿次甙E5) 纯度: ge;93.0%

Icariside E5 是从 Albiziae Cortex 分离得到的木脂素糖苷。Icariside E5 促进 HUVEC 的增殖而无细胞毒性。Icariside E5 具有抗氧化性能。

Icariside E5(Synonyms: 淫羊藿次甙E5)

Icariside E5 Chemical Structure

CAS No. : 126176-79-2

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生物活性

Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].

体外研究
(In Vitro)

Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS[1].
Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

522.54

Formula

C26H34O11

CAS 号

126176-79-2

中文名称

淫羊藿次甙E5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Xuelin Shi, et al. Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-Oxidation In Vitro. Molecules. 2019 Nov 7;24(22):4041.

    [2]. M Iorizzi, et al. New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity. J Agric Food Chem. 2001 Apr;49(4):2022-9.

Ramoplanin(Synonyms: 雷莫拉宁)

Ramoplanin;(Synonyms: 雷莫拉宁) 纯度: ge;92.0%

Ramoplanin 是一种源于 Actinoplanes spp 的糖肽类抗生素,具有抗革兰氏阳性菌活性。

Ramoplaninamp;;(Synonyms: 雷莫拉宁)

Ramoplanin Chemical Structure

CAS No. : 76168-82-6

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100 mg ¥3500 In-stock
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Ramoplanin 相关产品

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  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria[1][2].

IC50 Target

Bacteria[1]

体外研究
(In Vitro)

Ramoplanin exerts its bactericidal activity against gram-positive aerobic and anaerobic bacteria by blocking peptidoglycan synthesis via lipid II[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ramoplanin (100, 500 μg/ml; p.o.; for 8 days) suppresses vancomycin-resistant Enterococcus (VRE) to undetectable level during treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF1 mice (25-30 g)[1]
Dosage: 100 μg/ml, 500 μg/ml
Administration: Oral administration; for 8 days
Result: Developed undetectable levels of VRE in stool during treatment.

CAS 号

76168-82-6

中文名称

雷莫拉宁

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Stiefel U, et al. Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice. Antimicrob Agents Chemother. 2004 Jun;48(6):2144-8.

    [2]. Cheng M, et al. Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27.

Methylsyringin

天然产物 天然产物苯丙素类 Phenylpropanoids

Methylsyringin 

Methylsyringin 在 LPS 刺激的 RAW264.7 细胞中显示出抗炎活性。

Methylsyringin

Methylsyringin Chemical Structure

CAS No. : 139742-20-4

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生物活性

Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

分子量

386.39

Formula

C18H26O9

CAS 号

139742-20-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dong H, et al. Total Syntheses and Anti-inflammatory Activities of Syringin and Its Natural Analogues. J Nat Prod. 2021 Nov 26;84(11):2866-2874.

Licoricesaponin A3(Synonyms: 甘草皂苷A3)

天然产物 糖类和糖苷 Saccharides and Glycosides

Licoricesaponin A3;(Synonyms: 甘草皂苷A3) 纯度: 97.20%

Licoricesaponin A3 是甘草中的一种萜类皂苷。

Licoricesaponin A3(Synonyms: 甘草皂苷A3)

Licoricesaponin A3 Chemical Structure

CAS No. : 118325-22-7

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1 mg ¥6000 In-stock
5 mg ¥15000 询价
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生物活性

Licoricesaponin A3 is a terpenoid saponin identified from licorice[1].

分子量

985.07

Formula

C48H72O21

CAS 号

118325-22-7

中文名称

甘草皂苷A3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. Li D, et al. The Application of Ultra-High-Performance Liquid Chromatography Coupled with a LTQ-OrbitrapMass Technique to Reveal the Dynamic Accumulation of Secondary Metabolites in Licorice underABA Stress. Molecules. 2017 Oct 20;22(10). pii: E1742.