Mogroside III A2 是一种葫芦素糖苷。Mogroside III A2 可以抑制 Epstein-Barr 病毒早期抗原 (EBV-EA) 的激活。Mogroside III A2 对 NOR 1 的激活有弱的抑制作用。
Mogroside III A2 Chemical Structure
CAS No. : 88901-43-3
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生物活性
Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1[1].
IC50 Target
Epstein-Barr virus[1]
体外研究 (In Vitro)
Mogroside III A2 inhibits the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), with IC50 of 352 mol ratio/32 pmol TPA[1]. Mogroside III A2 shows weak inhibitory effects on activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
963.15
Formula
C48H82O19
CAS 号
88901-43-3
中文名称
罗汉果苷IIIA2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Akihisa T, et, al. Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2007 May;70(5):783-8.
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O2–, H2O2 and *OH) with EC50 of 4.79, 16.52, and 146.17 μg/mL, respectively.
11-oxo-mogroside V shows a higher scavenging effect on O2– (concentration at which 50% of chemiluminescence intensity is inhibited [EC50]=4.79 μg/mL) and H2O2 (EC50=16.52 μg/mL) than those of mogroside V. 11-oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC50=3.09 μg/mL[1].11-oxo-mogroside V, a natural sweetener, isolated from the fruits of Momordica grosvenori, exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000, 500 and 100 mol ratio/TPA concentration, respectively)[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
In the group treated with DMBA, TPA and 11-oxo-mogroside V, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1285.42
Formula
C60H100O29
CAS 号
126105-11-1
中文名称
11-氧-罗汉果苷 V;11-O-罗汉果苷 V
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Chen WJ, et al. The antioxidant activities of natural sweeteners, mogrosides, from fruits of Siraitia grosvenori. Int J Food Sci Nutr. 2007 Nov;58(7):548-56.
[2]. Takasaki M, et al. Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori. Cancer Lett. 2003 Jul 30;198(1):37-42.
Animal Administration [2]
Mice[2] Specific pathogen-free female ICR (6 weeks old) and female SENCAR (6 weeks old) mice are use. The animals (female SENCAR, 6 weeks old) are divided into three groups, 15 mice each. The back of each mouse is shaved with surgical clipper, and the mice are topically treated with peroxynitrite (33.1 μg, 390 nmol, 1 mM NaOH) in acetone (0.1 mL) as an initiation treatment. For groups I (control group) II and III, 1 week after initiation with peroxynitrite, mice are promoted by the application with TPA (1 mg, 1.7 nmol) in acetone (0.1 mL) twice a week. For groups II and III, mogroside V and 11-oxo-mogroside V (0.0025%, 2.5 mg/100 mL) in drinking water is given orally, from 1 week before to 1 week after the initiation treatment with peroxynitrite, respectively. The incidence of papillomas is observed weekly for 20 weeks; the percentages of mice bearing papillomas and the average number of papillomas per mouse are recorded. The type of tumors in our experiment is also checked by the pathologist with the histological examination, and the malignant tumors are not observed at 20 weeks of promotion in our experimental system. The tumor incidence is statistically analyzed by Student’s t-test in treated mice and controls.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Chen WJ, et al. The antioxidant activities of natural sweeteners, mogrosides, from fruits of Siraitia grosvenori. Int J Food Sci Nutr. 2007 Nov;58(7):548-56.
[2]. Takasaki M, et al. Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori. Cancer Lett. 2003 Jul 30;198(1):37-42.
Mogroside I E1(Synonyms: 罗汉果苷 I E1;罗汉果甜苷 I E1;罗汉果甙 I E1;罗汉果甜甙 I E1) 纯度: 99.11%
Mogroside I E1 是一种三萜糖苷。Mogroside I E1 是一种非糖类甜味剂。Mogroside 比蔗糖更甜。Mogroside 具有抗氧化,抗糖尿病和抗癌活性。
Mogroside I E1 Chemical Structure
CAS No. : 88901-39-7
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价格
是否有货
数量
5 mg
¥3360
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10 mg
¥5710
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100 mg
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Mogroside I E1 相关产品
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生物活性
Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].
分子量
638.87
Formula
C36H62O9
CAS 号
88901-39-7
中文名称
罗汉果苷 I E1;罗汉果甜苷 I E1;罗汉果甙 I E1;罗汉果甜甙 I E1
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
Mogroside IV 是一种三萜糖苷,可从罗汉果提取物中分离出来。Mogroside IV 是一种非糖类甜味剂。Mogroside 比蔗糖更甜。Mogroside 具有抗氧化,抗糖尿病和抗癌活性。
Mogroside IV Chemical Structure
CAS No. : 89590-95-4
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价格
是否有货
数量
5 mg
¥1780
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10 mg
¥3030
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¥5140
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100 mg
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生物活性
Mogroside IV, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].
分子量
1125.29
Formula
C54H92O24
CAS 号
89590-95-4
中文名称
罗汉果苷 IV;罗汉果甜苷 IV;罗汉果甙 IV;罗汉果甜甙 IV
运输条件
Room temperature in continental US; may vary elsewhere.
Mogroside I A1;(Synonyms: 罗汉果苷 I A1;罗汉果甜苷 I A1;罗汉果甙 I A1;罗汉果甜甙 I A1) 纯度: 99.77%
Mogroside I A1 是一种三萜糖苷。Mogroside I A1 是一种非糖类甜味剂。Mogroside 比蔗糖更甜。Mogroside 具有抗氧化,抗糖尿病和抗癌活性。
Mogroside I A1 Chemical Structure
CAS No. : 88901-46-6
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价格
是否有货
数量
5 mg
¥5040
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10 mg
¥8570
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50 mg
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100 mg
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Mogroside I A1 相关产品
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生物活性
Mogroside I A1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].
分子量
638.87
Formula
C36H62O9
CAS 号
88901-46-6
中文名称
罗汉果苷 I A1;罗汉果甜苷 I A1;罗汉果甙 I A1;罗汉果甜甙 I A1
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
Mogroside III 是一种三萜糖苷,是一种非糖类甜味剂。Mogroside 比蔗糖更甜。Mogroside 具有抗氧化,抗糖尿病和抗癌活性。
Mogroside III Chemical Structure
CAS No. : 130567-83-8
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价格
是否有货
数量
5 mg
¥2690
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¥4570
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50 mg
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Mogroside III 相关产品
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生物活性
Mogroside III is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].
分子量
963.15
Formula
C48H82O19
CAS 号
130567-83-8
中文名称
罗汉果苷 III;罗汉果甜苷 III;罗汉果甙 III;罗汉果甜甙 III
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
Mogroside V 是一种三萜糖苷,是一种非糖类甜味剂。Mogroside V 比蔗糖甜近 300倍。Mogrosides 具有抗氧化,抗糖尿病和抗癌活性。
Mogroside V Chemical Structure
CAS No. : 88901-36-4
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价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥1590
In-stock
5 mg
¥800
In-stock
10 mg
¥1120
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50 mg
¥3350
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100 mg
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200 mg
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Mogroside V 相关产品
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生物活性
Mogroside V is a triterpenoid glycoside and a nonsugar sweetener. Mogroside V is nearly 300 times sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities. Mogrosides are sweeter than sucrose[1].
分子量
1287.43
Formula
C60H102O29
CAS 号
88901-36-4
中文名称
罗汉果苷 V;罗汉果甜苷 V;罗汉果甙 V;罗汉果甜甙 V
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
Mogroside IV-A, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].
分子量
1125.29
Formula
C54H92O24
CAS 号
88901-41-1
中文名称
罗汉果苷 IV-A;罗汉果甜苷 IV-A;罗汉果甙 IV-A;罗汉果甜甙 IV-A
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Ukiya M, et al. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate. J Agric Food Chem. 2002 Nov 6;50(23):6710-5.