标签归档：mosloflavone

Mosloflavone

发表于由

天然产物 黄酮类 Flavonoids

Mosloflavone 

Mosloflavone 从 Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗 EV71 活性。Mosloflavone 在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。 Mosloflavone 是有前途的杀菌剂，可抑制铜绿假单胞菌的毒力和生物膜形成。

Mosloflavone

Mosloflavone Chemical Structure

CAS No. : 740-33-0

规格 价格 是否有货
5 mg ￥4030 询问价格 & 货期
10 mg ￥6860 询问价格 & 货期

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生物活性

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

IC50 & Target

IC50: EV71; bacterial[1][2]
体外研究
(In Vitro)

Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

298.29

Formula

C17H14O5
CAS 号

740-33-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. 2.Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8.

    [2]. 2.Hnamte S, et al. Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.Microb Pathog. 2019 Jun;131:128-134.

    [3]. 4.Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.