MOTS-c(human) acetate; 纯度: 99.57%
MOTS-c(human) acetate 是一种线粒体衍生的肽,可诱导 AMP 类似物 AICAR 的积累,增加 AMPK 的激活及其下游 GLUT4 的表达。MOTS-c(human) acetate 可诱导葡萄糖摄取并改善胰岛素敏感性,对肥胖,糖尿病,运动和长寿的调节具有影响。
MOTS-c(human) acetate Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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10 mg | ¥3000 | In-stock | |
50 mg | ¥7500 | In-stock | |
100 mg | ¥12500 | In-stock | |
200 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
MOTS-c(human) acetate 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
MOTS-c(human) acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity[1]. |
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IC50 Target[1] |
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体外研究 (In Vitro) |
MOTS-c inhibits the folate cycle at the level of 5Me-THF, resulting in an accumulation of AICAR [5-aminoimidazole-4-carboxamide ribonucleotide). MOTS-c also increases cellular NAD+ levels, which are also nucleotide precursors[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
MOTS-c injections in mice show activation of skeletal muscle AMPK and increased the level of its downstream glucose transporter GLUT4. MOTS-c may also act as a potential mitochondrial signal that mediates an exercise-induced mitohormesis response, thereby stimulating physiological adaptation and increased tolerance to exercise[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
2234.64 |
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Formula |
C103H156N28O24S2 |
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Sequence |
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
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Sequence Shortening |
MRWQEMGYIFYPRKLR |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
DMSO : 4 mg/mL (1.79 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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