标签归档：mouse

PEN(mouse)(Synonyms: proSAAS(221-242))

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PEN(mouse);(Synonyms: proSAAS(221-242))

PEN(mouse) (proSAAS(221-242)) 是一种多肽的前体，可用作神经肽。

PEN(mouse)amp;;(Synonyms: proSAAS(221-242))

PEN(mouse) Chemical Structure

CAS No. : 1236955-25-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

PEN(mouse) (proSAAS(221-242)) is the precursor of a number of peptides that function as neuropeptides[1].

分子量

2317.59

Formula

C102H169N27O34
CAS 号

1236955-25-1
Sequence Shortening

SVDQDLGPEVPPENVLGALLRV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Jonathan H Wardman , et al. ProSAAS-derived Peptides Are Colocalized With Neuropeptide Y and Function as Neuropeptides in the Regulation of Food Intake. PLoS One. 2011;6(12):e28152.

Enterostatin(human,mouse,rat) TFA

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Enterostatin(human,mouse,rat) TFA;

Enterostatin (human,mouse,rat) TFA 是一种五肽，主要由胰前脂酶在肠道中裂解而形成。Enterostatin 可以选择性地降低脂肪摄取量、体重和体脂。

Enterostatin(human,mouse,rat) TFAamp;;

Enterostatin(human,mouse,rat) TFA Chemical Structure

规格 价格 是否有货
1 mg ￥350 询问价格 货期
5 mg ￥1050 询问价格 货期
10 mg ￥1650 询问价格 货期

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生物活性

Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin  selectively reduces fat intake, bodyweight, and body fat in vivo[1].

分子量

610.58

Formula

C23H37F3N8O8
Sequence

Ala-Pro-Gly-Pro-Arg
Sequence Shortening

APGPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. C Erlanson-Albertsson, et al. Enterostatin–a Peptide Regulating Fat Intake. Obes Res. 1997 Jul;5(4):360-72

Neuropeptide S(Mouse)

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Neuropeptide S(Mouse);

Neuropeptide S (Mouse) 是一种生物活性肽。Neuropeptide S (Mouse) 作为 20 个氨基酸的神经递质/神经调节因子，可用于觉醒、焦虑、运动、进食行为、记忆和药物成瘾的研究。

Neuropeptide S(Mouse)amp;;

Neuropeptide S(Mouse) Chemical Structure

CAS No. : 412938-74-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and drug addiction[1].

分子量

2182.47

Formula

C93H156N34O27
CAS 号

412938-74-0
Sequence Shortening

SFRNGVGSGAKKTSFRRAKQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Peng YL, et al. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-1883.

Neuropeptide S(Mouse) TFA

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Neuropeptide S(Mouse) TFA;

Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca2+. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

Neuropeptide S(Mouse) TFAamp;;

Neuropeptide S(Mouse) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca2+. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

分子量

2296.49

Formula

C92H157F3N34O29
Sequence Shortening

SFRNGVGSGAKKTSFRRAKQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Parstatin(mouse)

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Parstatin(mouse);

Parstatin(mouse) 是具有细胞通透性的 PAR-1 凝血酶受体的肽类激动剂，是一种有效的血管生成抑制剂。

Parstatin(mouse)amp;;

Parstatin(mouse) Chemical Structure

CAS No. : 1065756-01-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis[1][2].

体外研究
(In Vitro)

Parstatin (0-10 µM) increases recovery of LVDP in a concentration-dependent manner. The optimal concentration was 1 µM which produced a 23% recovery of LVDP[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Parstatin (single dose, 1-25 µg/kg, iv) administered prior to ischaemia confers immediate cardioprotection by recruiting the Gi-protein activation pathway including p38 MAPK, ERK1/2, NOS, and KATP channels. Parstatin exerts effects on both the cardiomyocytes and the coronary circulation to induce cardioprotection. This suggests a potential therapeutic role of parstatin in the treatment of cardiac injury resulting from ischaemia and reperfusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats at 8 weeks of age (250-300 g)[1].
Dosage: 1-25 µg/kg.
Administration: IV injected 15 min prior to ischaemia.
Result: A significant decrease in infarct size was detected with the 5-15 µg/kg doses with 10 µg/kg as the optimal dose. These hearts had an infarct size of 46 ± 3% of the area at risk, which is a 26% reduction in infarct size compared with the control.

分子量

4419.16

Formula

C189H326N58O57S3
CAS 号

1065756-01-5
Sequence Shortening

MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Panagiota Zania, et al. Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis. J Pharmacol Exp Ther. 2009 Feb;328(2):378-89.

    [2]. Jennifer L Strande, et al. Parstatin: A Cryptic Peptide Involved in Cardioprotection After Ischaemia and Reperfusion Injury. Cardiovasc Res. 2009 Jul 15;83(2):325-34.

Parstatin(mouse) TFA

发表于由

Parstatin(mouse) TFA;

Parstatin(mouse) TFA 是具有细胞通透性的 PAR-1 凝血酶受体的肽类激动剂，是一种有效的血管生成抑制剂。

Parstatin(mouse) TFAamp;;

Parstatin(mouse) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Parstatin(mouse) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis[1][2].

体外研究
(In Vitro)

Parstatin (0-10 µM) increases recovery of LVDP in a concentration-dependent manner. The optimal concentration was 1 µM which produced a 23% recovery of LVDP[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Parstatin (single dose, 1-25 µg/kg, iv) administered prior to ischaemia confers immediate cardioprotection by recruiting the Gi-protein activation pathway including p38 MAPK, ERK1/2, NOS, and KATP channels. Parstatin exerts effects on both the cardiomyocytes and the coronary circulation to induce cardioprotection. This suggests a potential therapeutic role of parstatin in the treatment of cardiac injury resulting from ischaemia and reperfusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats at 8 weeks of age (250-300 g)[1].
Dosage: 1-25 µg/kg.
Administration: IV injected 15 min prior to ischaemia.
Result: A significant decrease in infarct size was detected with the 5-15 µg/kg doses with 10 µg/kg as the optimal dose. These hearts had an infarct size of 46 ± 3% of the area at risk, which is a 26% reduction in infarct size compared with the control.

分子量

4533.18

Formula

C191H327F3N58O59S3
Sequence Shortening

MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Panagiota Zania, et al. Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis. J Pharmacol Exp Ther. 2009 Feb;328(2):378-89.

    [2]. Jennifer L Strande, et al. Parstatin: A Cryptic Peptide Involved in Cardioprotection After Ischaemia and Reperfusion Injury. Cardiovasc Res. 2009 Jul 15;83(2):325-34.

BigLEN(mouse) TFA

发表于由

BigLEN(mouse) TFA;

BigLEN(mouse) TFA is a GPR171 agonist. BigLEN(mouse) TFA is a proSAAS-derived neuropeptide. BigLEN(mouse) TFA regulates food intake in mice. BigLEN(mouse) inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

BigLEN(mouse) TFAamp;;

BigLEN(mouse) TFA Chemical Structure

规格 是否有货
1 mg 询价
5 mg 询价
10 mg 询价

* Please select Quantity before adding items.

生物活性

BigLEN(mouse) TFA is a GPR171 agonist. BigLEN(mouse) TFA is a proSAAS-derived neuropeptide. BigLEN(mouse) TFA regulates food intake in mice. BigLEN(mouse) inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

分子量

1870.04

Formula

C80H131F3N24O24
Sequence Shortening

LENPSPQAPARRLLPP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Neuropeptide SF(mouse,rat) TFA

发表于由

Neuropeptide SF(mouse,rat) TFA;

Neuropeptide SF (mouse,rat) TFA 是一种有效的神经肽 FF 受体 (neuropeptide FF receptor) 激动剂，NPFF1 和 NPFF2 的 Ki 值分别为 48.4 nM 和 12.1 nM。Neuropeptide SF (mouse,rat) TFA 可以增加异表达酸感离子通道 3 (ASIC3) 的持续电流幅值。

Neuropeptide SF(mouse,rat) TFAamp;;

Neuropeptide SF(mouse,rat) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) [1].

IC50 Target

Neuropeptide FF Receptor Agonist
分子量

1002.05

Formula

C42H66F3N13O12
Sequence Shortening

SLAAPQRF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Miklós Jászberényi, et al. The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats.Regul Pept. 2014 Jan 10;188:46-51.

    [2]. K Jhamandas, et al. Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides.Peptides. 2006 May;27(5):953-63.

    [3]. C Gouardères, et al. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61.

MCH(human, mouse, rat)

发表于由

MCH(human, mouse, rat);

MCH (human, mouse, rat) 是一种有效的 MCH-R  的肽激动剂，与 MCH1R 和 MCH2R 结合的 IC50 值分别为 0.3nM 和 1.5 nM。MCH (human, mouse, rat) 对 CHO 细胞系中 MCH-2R 高度敏感，通过 FLIPR 监测细胞内钙动员，显示出功能性激活 MCH-1R 和 MCH-2R 的 EC50 值对分别为 3.9 nM 和 0.1 nM。

MCH(human, mouse, rat)amp;;

MCH(human, mouse, rat) Chemical Structure

CAS No. : 128315-56-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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MCH(human, mouse, rat) 的其他形式现货产品:

MCH(human, mouse, rat) TFA

生物活性

MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1].

IC50 Target

Binding IC50: 0.3 nM (MCH1R)
IC50: 1.5 nM (MCH1R)[1]
分子量

2386.84

Formula

C105H160N30O26S4
CAS 号

128315-56-0
Sequence Shortening

DFDMLRCMLGRVYRPCWQV (Disulfide bridge:Cys7-Cys16)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.

Neuropeptide SF(mouse,rat)

发表于由

Neuropeptide SF(mouse,rat);

Neuropeptide SF (mouse,rat) 是一种有效的神经肽 FF 受体 (neuropeptide FF receptor) 激动剂，NPFF1 和 NPFF2 的 Ki 值分别为 48.4 nM 和 12.1 nM。Neuropeptide SF (mouse,rat) 可以增加异表达酸感离子通道 3 (ASIC3) 的持续电流幅值。

Neuropeptide SF(mouse,rat)amp;;

Neuropeptide SF(mouse,rat) Chemical Structure

CAS No. : 230960-31-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) [1].

IC50 Target

Ki: 48.4 nM (NPFF1)
Ki: 12.1 nM (NPFF2)[1]
分子量

888.03

Formula

C40H65N13O10
CAS 号

230960-31-3
Sequence Shortening

SLAAPQRF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Miklós Jászberényi, et al. The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats.Regul Pept. 2014 Jan 10;188:46-51.

    [2]. C Gouardères, et al. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61.