Melanotan (MT)-II;(Synonyms: 美拉诺坦 (MT)-II) 纯度: 99.18%
Melanotan (MT)-II是一种合成的黑皮质素 (melanocortin) 受体激动剂。它是可注射用的多肽荷尔蒙,可促进晒黑。
Melanotan (MT)-II Chemical Structure
CAS No. : 121062-08-6
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1 mg | ¥800 | In-stock | |
5 mg | ¥1600 | In-stock | |
10 mg | ¥2200 | In-stock | |
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Melanotan (MT)-II 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Macrocyclic Compound Library
- Peptide Library
生物活性 |
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning. |
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体外研究 (In Vitro) |
Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems such as the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after i.v. melanotan (MT)-II (1 mg/kg), thereby exerting facilitator effect on erection[2]. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg[3]. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction[4]. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1024.18 |
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Formula |
C50H69N15O9 |
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CAS 号 |
121062-08-6 |
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Sequence |
Ac-{Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys-NH2, (2rarr;7)-lactam |
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Sequence Shortening |
Ac-{Nle}-DH-{d-Phe}-RWK-NH2, (2rarr;7)-lactam |
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中文名称 |
美拉诺坦 (MT)-II |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
H2O : 6.67 mg/mL (6.51 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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Animal Administration [2][5] |
Rats: To investigate the inducer activity on erection, melanotan (MT)-II or vehicle (saline) is acutely injected i.v., i.t. or within the PVN after a 5 min baseline recording period is obtained. ICP and MAP are then recorded for a 60 min period after saline or melanotan (MT)-II delivery. I.v. injections (three doses; 0.1, 0.3, and 1 mg/kg in saline) are performed with a catheter inserted in the jugular vein[2]. Mice: Melanotan (MT)-II (0.1 and 0.2 nM) or vehicle (artificial cerebrospinal fluid) is administered. SPA is recorded continuously every 5 min. Food intake measurements are taken 6 and 24 h postinjection. Body weight is measured every 24 h. Chow and water are available ad libitum. A 48-h interval occurrs between drug treatments[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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