Substance P;(Synonyms: P物质; Neurokinin P) 纯度: 99.37%
Substance P (Neurokinin P) 是一种神经肽,在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor,NK1R)。

Substance P Chemical Structure
CAS No. : 33507-63-0
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥500 | In-stock | |
5 mg | ¥1100 | In-stock | |
10 mg | ¥2000 | In-stock | |
25 mg | ¥4500 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Substance P 相关产品
bull;相关化合物库:
- Natural Product Library Plus
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Metabolism/Protease Compound Library
- Neuronal Signaling Compound Library
- Natural Product Library
- Clinical Compound Library
- CNS-Penetrant Compound Library
- Human Endogenous Metabolite Compound Library
- Drug Repurposing Compound Library
- Endocrinology Compound Library
- Neurotransmitter Receptor Compound Library
- Food-Sourced Compound Library
- Peptide Library
生物活性 |
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). |
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IC50 Target |
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体外研究 (In Vitro) |
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
1347.63 |
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Formula |
C63H98N18O13S |
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CAS 号 |
33507-63-0 |
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Sequence |
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
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Sequence Shortening |
RPKPQQFFGLM-NH2 |
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中文名称 |
P物质 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : 25 mg/mL (18.55 mM; Need ultrasonic) H2O : ≥ 20 mg/mL (14.84 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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