标签归档：neurokinin

Neurokinin A(4-10)(Synonyms: 神经激肽 A (4-10))

发表于由

Neurokinin A(4-10);(Synonyms: 神经激肽 A (4-10))

Neurokinin A (4-10) 是速激肽 NK2 受体激动剂。

Neurokinin A(4-10)amp;;(Synonyms: 神经激肽 A (4-10))

Neurokinin A(4-10) Chemical Structure

CAS No. : 97559-35-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Neurokinin A(4-10) 的其他形式现货产品:

Neurokinin A(4-10) TFA

生物活性

Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.

IC50 Target

NK2 receptor[1]
体外研究
(In Vitro)

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

766.91

Formula

C34H54N8O10S
CAS 号

97559-35-8
Sequence

Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

DSFVGLM-NH2
中文名称

神经激肽 A (4-10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.

Substance P(Synonyms: P物质 Neurokinin P)

发表于由

Substance P;(Synonyms: P物质; Neurokinin P) 纯度: 99.37%

Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)。

Substance Pamp;;(Synonyms: P物质; Neurokinin P)

Substance P Chemical Structure

CAS No. : 33507-63-0

规格 价格 是否有货 数量
1 mg ￥500 In-stock
5 mg ￥1100 In-stock
10 mg ￥2000 In-stock
25 mg ￥4500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Substance P 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Metabolism/Protease Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • Clinical Compound Library
  • CNS-Penetrant Compound Library
  • Human Endogenous Metabolite Compound Library
  • Drug Repurposing Compound Library
  • Endocrinology Compound Library
  • Neurotransmitter Receptor Compound Library
  • Food-Sourced Compound Library
  • Peptide Library

生物活性

Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1347.63

Formula

C63H98N18O13S
CAS 号

33507-63-0
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

RPKPQQFFGLM-NH2
中文名称

P物质
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 25 mg/mL (18.55 mM; Need ultrasonic)

H2O : ≥ 20 mg/mL (14.84 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7420 mL 3.7102 mL 7.4204 mL
5 mM 0.1484 mL 0.7420 mL 1.4841 mL
10 mM 0.0742 mL 0.3710 mL 0.7420 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.86 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.86 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.86 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

    [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.

Neurokinin B TFA(Synonyms: 神经激肽 B 三氟乙酸盐)

发表于由

Neurokinin B TFA;(Synonyms: 神经激肽 B 三氟乙酸盐) 纯度: 96.64%

Neurokinin B TFA 属于速激肽家族。Neurokinin 结合到一系列 G 蛋白偶联受体 (GPCR)-包括神经激肽受体1 (NK1R)，NK2R 和 NK3R，且介导其生物学作用。

Neurokinin B TFAamp;;(Synonyms: 神经激肽 B 三氟乙酸盐)

Neurokinin B TFA Chemical Structure

CAS No. : 101536-55-4

规格 价格 是否有货 数量
1 mg ￥900 In-stock
5 mg ￥3600 In-stock
10 mg ￥6400 In-stock
25 mg ￥12500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].

IC50 Target

Neurokinin receptor[1]
分子量

1438.47

Formula

C55H79N13O14S2.2C2HF3O2
CAS 号

101536-55-4
Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

DMHDFFVGLM-NH2
中文名称

神经激肽 B 三氟乙酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 2.5 mg/mL (1.74 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6952 mL 3.4759 mL 6.9518 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47.

Substance P TFA(Synonyms: Neurokinin P TFA)

发表于由

Substance P TFA;(Synonyms: Neurokinin P TFA) 纯度: 99.60%

Substance P TFA (Neurokinin P TFA) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)。

Substance P TFAamp;;(Synonyms: Neurokinin P TFA)

Substance P TFA Chemical Structure

CAS No. : 148470-19-3

规格 价格 是否有货 数量
1 mg ￥500 In-stock
5 mg ￥1100 In-stock
10 mg ￥2000 In-stock
25 mg ￥4500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Substance P TFA 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

IC50 Target

Neurokinin 1 receptor[1]
体外研究
(In Vitro)

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1461.67

Formula

C65H99F3N18O15S
CAS 号

148470-19-3
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

RPKPQQFFGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (68.41 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6841 mL 3.4207 mL 6.8415 mL
5 mM 0.1368 mL 0.6841 mL 1.3683 mL
10 mM 0.0684 mL 0.3421 mL 0.6841 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

    [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.

Neurokinin A TFA(Synonyms: Substance K TFA Neurokinin α TFA Neuromedin L TFA)

发表于由

Neurokinin A TFA;(Synonyms: Substance K TFA; Neurokinin α TFA; Neuromedin L TFA) 纯度: 99.25%

Neurokinin A TFA (Substance K TFA) 是速激肽家族的一种肽类神经递质，通过 NK-2 受体发挥作用。在人气道和胃肠道组织中作为主要的介体。

Neurokinin A TFAamp;;(Synonyms: Substance K TFA; Neurokinin α TFA; Neuromedin L TFA)

Neurokinin A TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥1500 In-stock
10 mg ￥2600 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Neurokinin A TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Endocrinology Compound Library
  • Neurotransmitter Receptor Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1].

体外研究
(In Vitro)

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1247.34

Formula

C52H81N14F3O16S
Sequence Shortening

HKTDSFVGLM-NH2
中文名称

神经激肽 A 三氟乙酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (80.17 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8017 mL 4.0085 mL 8.0171 mL
5 mM 0.1603 mL 0.8017 mL 1.6034 mL
10 mM 0.0802 mL 0.4009 mL 0.8017 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (2.00 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.00 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.00 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.00 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.00 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.00 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62.

Neurokinin A(Synonyms: Substance K Neurokinin α Neuromedin L)

发表于由

Neurokinin A;(Synonyms: Substance K; Neurokinin α; Neuromedin L)

Neurokinin A (Substance K) 是速激肽家族的一种肽类神经递质，通过 NK-2 受体发挥作用。在人气道和胃肠道组织中作为主要的介体。

Neurokinin Aamp;;(Synonyms: Substance K; Neurokinin α; Neuromedin L)

Neurokinin A Chemical Structure

CAS No. : 86933-74-6

规格 价格 是否有货 数量
25 mg 询价
1 mg ￥1000 询价
5 mg ￥4000 询价
10 mg ￥7200 询价
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1].

IC50 Target

NK-2 receptor[1]
体外研究
(In Vitro)

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1133.32

Formula

C50H80N14O14S
CAS 号

86933-74-6
Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

HKTDSFVGLM-NH2
中文名称

神经激肽 A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62.

Neurokinin A(4-10) TFA

发表于由

Neurokinin A(4-10) TFA; 纯度: 98.10%

Neurokinin A (4-10) TFA 是速激肽 NK2 受体激动剂。

Neurokinin A(4-10) TFAamp;;

Neurokinin A(4-10) TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥700 In-stock
5 mg ￥2800 In-stock
10 mg ￥4900 In-stock
25 mg ￥9900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Neurokinin A(4-10) TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].

IC50 Target

NK2 receptor[1]
体外研究
(In Vitro)

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

880.93

Formula

C36H55F3N8O12S
Sequence

Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

DSFVGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 0.67 mg/mL (0.76 mM; Need ultrasonic)
参考文献

  • [1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.

[bAla8]-Neurokinin A(4-10)(Synonyms: MEN 10210)

发表于由

[bAla8]-Neurokinin A(4-10);(Synonyms: MEN 10210) 纯度: 98.17%

[bAla8]-Neurokinin A(4-10) 是一种神经激肽-2 受体 (neurokinin 2 receptor) 激动剂。

[bAla8]-Neurokinin A(4-10)amp;;(Synonyms: MEN 10210)

[bAla8]-Neurokinin A(4-10) Chemical Structure

CAS No. : 122063-01-8

规格 价格 是否有货 数量
1 mg ￥1500 In-stock
5 mg ￥4200 In-stock
10 mg ￥7000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

[bAla8]-Neurokinin A(4-10) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

分子量

780.93

Formula

C35H56N8O10S
CAS 号

122063-01-8
Sequence

Asp-Ser-Phe-Val-{Bal}-Leu-Met-NH2
Sequence Shortening

DSFV-{Bal}-LM-NH2
中文名称

[bAla8]-神经激肽 A (4-10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month

Neurokinin B(Synonyms: 神经激肽 B)

发表于由

Neurokinin B;(Synonyms: 神经激肽 B)

Neurokinin B 属于速激肽家族。Neurokinin结合到一系列 G 蛋白偶联受体 (GPCR)-包括神经激肽受体 1 (NK1R)，NK2R 和 NK3R，且介导其生物学作用。

Neurokinin Bamp;;(Synonyms: 神经激肽 B)

Neurokinin B Chemical Structure

CAS No. : 86933-75-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Neurokinin B 的其他形式现货产品:

Neurokinin B TFA

生物活性

Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].

IC50 Target

Neurokinin receptor[1]
体外研究
(In Vitro)

Neurokinin B (NKB) belongs to the tachykinin family of peptides that initially included the neuropeptides substance P (SP), neurokinin A (NKA), and NKB and more recently, endokinins and hemokinins. Tachykinins bind a family of G-protein-coupled receptors (GPCRs)-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1210.42

Formula

C55H79N13O14S2
CAS 号

86933-75-7
Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

DMHDFFVGLM-NH2
中文名称

神经激肽 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47.