Neuromedin S(rat)

Neuromedin S(rat);

Neuromedin S(rat) 是由 34 个氨基酸组成的肽段,来源于大鼠 Neuromedin S 。Neuromedin S 是从大鼠大脑分离出的神经肽,可以作为 FM4/TGR-1 的配体

Neuromedin S(rat)amp;;

Neuromedin S(rat) Chemical Structure

CAS No. : 843782-19-4

规格 是否有货
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生物活性

Neuromedin S(rat) is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1[1]

分子量

2642.97

Formula

C124H180N34O31

CAS 号

843782-19-4

Sequence Shortening

LPRLLHTDSRATIDFPKKDATIDFPKKDLFRPRN-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. E Vigo, et al. Neuromedin s as novel putative regulator of luteinizing hormone secretion. Endocrinology. 2007 Feb;148(2):813-23.

Neuromedin S(rat) TFA

Neuromedin S(rat) TFA;

Neuromedin S(rat) TFA 是由 34 个氨基酸组成的肽段,来源于大鼠 Neuromedin S 。Neuromedin S 是从大鼠大脑分离出的神经肽,可以作为 FM4/TGR-1 的配体。

Neuromedin S(rat) TFAamp;;

Neuromedin S(rat) TFA Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Neuromedin S(rat) TFA is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1[1]

分子量

2756.99

Formula

C126H181F3N34O33

Sequence Shortening

LPRLLHTDSRATIDFPKKDATIDFPKKDLFRPRN-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. E Vigo, et al. Neuromedin s as novel putative regulator of luteinizing hormone secretion. Endocrinology. 2007 Feb;148(2):813-23.

Neuromedin U, rat TFA(Synonyms: Neuromedin U (rat) (TFA) Rat neuromedin U-23 TFA)

Neuromedin U, rat TFA;(Synonyms: Neuromedin U (rat) (TFA); Rat neuromedin U-23 TFA) 纯度: 98.84%

Neuromedin U, rat TFA 是一种含 23 个氨基酸的脑肠肽,,通过其中枢神经系统中的同源受体 NMUR2 调节几种重要的生理功能,包括能量平衡,应激反应和伤害感受。

Neuromedin U, rat TFAamp;;(Synonyms: Neuromedin U (rat) (TFA); Rat neuromedin U-23 TFA)

Neuromedin U, rat TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥2400 In-stock
5 mg ¥7000 In-stock
10 mg ; 询价 ;
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Neuromedin U, rat TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

分子量

2756.99

Formula

C126H181N34F3O33

Sequence

Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2

Sequence Shortening

YKVNEYQGPVAPSGGFFLFRPRN-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 100 mg/mL (36.27 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3627 mL 1.8136 mL 3.6271 mL
5 mM 0.0725 mL 0.3627 mL 0.7254 mL
10 mM 0.0363 mL 0.1814 mL 0.3627 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Liu JJ, et al. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther. 2009 Jul;330(1):268-75.

Neuromedin B(Synonyms: 神经介素 B)

Neuromedin B;(Synonyms: 神经介素 B) 纯度: 98.08%

Neuromedin B 是一种含10个氨基酸的神经肽,属于蛙肽家族,为铃蟾肽相关肽。

Neuromedin Bamp;;(Synonyms: 神经介素 B)

Neuromedin B Chemical Structure

CAS No. : 87096-84-2

规格 价格 是否有货 数量
1 mg ¥800 In-stock
5 mg ¥3100 In-stock
10 mg ¥5400 In-stock
25 mg ¥11000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Neuromedin B 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1132.29

Formula

C52H73N15O12S

CAS 号

87096-84-2

Sequence

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2

Sequence Shortening

GNLWATGHFM-NH2

中文名称

神经介素 B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 12.5 mg/mL (11.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8832 mL 4.4158 mL 8.8317 mL
5 mM 0.1766 mL 0.8832 mL 1.7663 mL
10 mM 0.0883 mL 0.4416 mL 0.8832 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.

Neuromedin N(Synonyms: Neuromedin N (rat, mouse, porcine, canine))

Neuromedin N;(Synonyms: Neuromedin N (rat, mouse, porcine, canine)) 纯度: 99.49%

Neuromedin N 是大鼠多巴胺 D2 受体激动剂结合新纹状体膜的有效调节剂。

Neuromedin Namp;;(Synonyms: Neuromedin N (rat, mouse, porcine, canine))

Neuromedin N Chemical Structure

CAS No. : 92169-45-4

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ¥1559 In-stock
5 mg ¥950 In-stock
10 mg ¥1400 In-stock
25 mg ¥3000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Neuromedin N 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Peptidomimetic Library
  • Neurotransmitter Receptor Compound Library
  • Peptide Library

生物活性

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

IC50 Target

Dopamine D2 receptor[1].

体外研究
(In Vitro)

Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

745.95

Formula

C38H63N7O8

CAS 号

92169-45-4

Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Sequence Shortening

KIPYIL

中文名称

神经介素 N

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (67.03 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3406 mL 6.7029 mL 13.4057 mL
5 mM 0.2681 mL 1.3406 mL 2.6811 mL
10 mM 0.1341 mL 0.6703 mL 1.3406 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4.

    [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.