标签归档：neuropeptide

[D-Trp34]-Neuropeptide Y TFA

发表于由

[D-Trp34]-Neuropeptide Y TFA;

[D-Trp34]-Neuropeptide Y TFA 是有效的，选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y TFA 在 NPY Y1，Y2，Y4 和 y6 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y TFA 明显增加大鼠的食物摄入量。

[D-Trp34]-Neuropeptide Y TFAamp;;

[D-Trp34]-Neuropeptide Y TFA Chemical Structure

规格 是否有货
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生物活性

[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats[1][2].

IC50 Target[1]

NPY Y5 receptor

;

体外研究
(In Vitro)

[D-Trp34]-Neuropeptide Y TFA has pKi values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5 in CHO cells. [D-Trp34]-Neuropeptide Y TFA has pEC50 values of 6.44, <6, 6.28，7.82 for rY1, rY2 in CHO cells and rY4, rY5 in HEK-293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

[D-Trp34]-Neuropeptide Y TFA (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2466.76

Formula

C112H171F3N34O26
Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9.

    [2]. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4.

[D-Arg25]-Neuropeptide Y (human)

发表于由

[D-Arg25]-Neuropeptide Y (human);

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是 Y1 受体的选择性激动剂。Neuropeptide Y (human) 和阿尔兹海默症相关，能够保护老鼠皮质神经元对抗淀粉样蛋白毒性。

[D-Arg25]-Neuropeptide Y (human)amp;;

[D-Arg25]-Neuropeptide Y (human) Chemical Structure

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生物活性

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer’s disease (AD) and protects rat cortical neurons against β-Amyloid toxicity[1].

体外研究
(In Vitro)

[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4271.68

Formula

C189H285N55O57S
Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSAL-{D-Arg}-HYINLITRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kilian Kuhn, et al. Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonists. zur Erlangung des Doktorgrades der Naturwissenschaften an der Fakultät für Chemie und Pharmazie der Universität Regensburg.

    [2]. Li-Ying Fu, et al. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004 Oct 6;24(40):8741-51.

    [3]. Ambikaipakan Balasubramaniam, et al. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr Pharm Des. 2003;9(15):1165-75.

Neuropeptide S(Mouse)

发表于由

Neuropeptide S(Mouse);

Neuropeptide S (Mouse) 是一种生物活性肽。Neuropeptide S (Mouse) 作为 20 个氨基酸的神经递质/神经调节因子，可用于觉醒、焦虑、运动、进食行为、记忆和药物成瘾的研究。

Neuropeptide S(Mouse)amp;;

Neuropeptide S(Mouse) Chemical Structure

CAS No. : 412938-74-0

规格 是否有货
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生物活性

Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and drug addiction[1].

分子量

2182.47

Formula

C93H156N34O27
CAS 号

412938-74-0
Sequence Shortening

SFRNGVGSGAKKTSFRRAKQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Peng YL, et al. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-1883.

Neuropeptide S(Mouse) TFA

发表于由

Neuropeptide S(Mouse) TFA;

Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca2+. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

Neuropeptide S(Mouse) TFAamp;;

Neuropeptide S(Mouse) TFA Chemical Structure

规格 是否有货
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生物活性

Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca2+. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

分子量

2296.49

Formula

C92H157F3N34O29
Sequence Shortening

SFRNGVGSGAKKTSFRRAKQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Neuropeptide S(Rat)

发表于由

Neuropeptide S(Rat);

Neuropeptide S (Rat) 是一种内源性配体，以前被称为 orphan G-protein-coupled 受体，现在被称为 NPS 受体。Neuropeptide S (Rat) 可用于神经系统疾病的研究。

Neuropeptide S(Rat)amp;;

Neuropeptide S(Rat) Chemical Structure

CAS No. : 412938-75-1

规格 是否有货
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生物活性

Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease[1].

分子量

2210.52

Formula

C95H160N34O27
CAS 号

412938-75-1
Sequence Shortening

SFRNGVGSGVKKTSFRRAKQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Vitale G, et al. Anxiolytic-like effect of neuropeptide S in the rat defensive burying. Peptides. 2008;29(12):2286-2291.

Neuropeptide EI, rat

发表于由

Neuropeptide EI, rat;

Neuropeptide EI, rat 是一种黑色素聚集激素 (MCH) 拮抗剂，同时是一种黑素细胞刺激素 (MSH) 激动剂。

Neuropeptide EI, ratamp;;

Neuropeptide EI, rat Chemical Structure

CAS No. : 125934-45-4

规格 是否有货
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生物活性

Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms[1].

分子量

1447.55

Formula

C63H98N16O23
CAS 号

125934-45-4
Sequence

Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-NH2
Sequence Shortening

EIGDEENSAKFPI-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Hintermann E, et al. Interaction of melanin-concentrating hormone (MCH), neuropeptide E-I (NEI), neuropeptide G-E (NGE), and alpha-MSH with melanocortin and MCH receptors on mouse B16 melanoma cells. J Recept Signal Transduct Res. 2001 Feb;21(1):93-116.

Neuropeptide SF(mouse,rat) TFA

发表于由

Neuropeptide SF(mouse,rat) TFA;

Neuropeptide SF (mouse,rat) TFA 是一种有效的神经肽 FF 受体 (neuropeptide FF receptor) 激动剂，NPFF1 和 NPFF2 的 Ki 值分别为 48.4 nM 和 12.1 nM。Neuropeptide SF (mouse,rat) TFA 可以增加异表达酸感离子通道 3 (ASIC3) 的持续电流幅值。

Neuropeptide SF(mouse,rat) TFAamp;;

Neuropeptide SF(mouse,rat) TFA Chemical Structure

规格 是否有货
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生物活性

Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) [1].

IC50 Target

Neuropeptide FF Receptor Agonist
分子量

1002.05

Formula

C42H66F3N13O12
Sequence Shortening

SLAAPQRF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Miklós Jászberényi, et al. The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats.Regul Pept. 2014 Jan 10;188:46-51.

    [2]. K Jhamandas, et al. Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides.Peptides. 2006 May;27(5):953-63.

    [3]. C Gouardères, et al. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61.

Neuropeptide Y, porcine TFA

发表于由

Neuropeptide Y, porcine TFA;

Neuropeptide Y, porcine TFA 是存在于猪脑中的多肽，能够抑制分泌素刺激的胰腺分泌。

Neuropeptide Y, porcine TFAamp;;

Neuropeptide Y, porcine TFA Chemical Structure

规格 是否有货
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生物活性

Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion[1].

分子量

4253.13

Formula

C190H287N55O57.C2HF3O2
Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. K Tatemoto, et al. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5485-9.

[Leu31,Pro34]-Neuropeptide Y (porcine)

发表于由

[Leu31,Pro34]-Neuropeptide Y (porcine); 纯度: 98.66%

[Leu31,Pro34]- Neuropeptide Y (porcine) 是一种神经肽 Y (NPY) 类似物，是一种选择性的 NPY Y1 受体激动剂。[Leu31,Pro34]- Neuropeptide Y (porcine) 表现出抗焦虑作用。

[Leu31,Pro34]-Neuropeptide Y (porcine)amp;;

[Leu31,Pro34]-Neuropeptide Y (porcine) Chemical Structure

CAS No. : 125580-28-1

规格 价格 是否有货 数量
1 mg ￥1300 In-stock
5 mg ￥3900 In-stock
10 mg ￥6200 In-stock
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[Leu31,Pro34]-Neuropeptide Y (porcine) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects[1][2].

IC50 Target[1]

NPY Y1 receptor

;

体内研究
(In Vivo)

[Leu31,Pro34]-Neuropeptide Y (porcine) displaces radiolabeled NPY from cells that express Y1 receptors in a series of human neuroblastoma cell lines and on rat PC-12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4222.63

Formula

C190H286N54O56
CAS 号

125580-28-1
Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLLTRPRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 100 mg/mL (23.68 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2368 mL 1.1841 mL 2.3682 mL
5 mM 0.0474 mL 0.2368 mL 0.4736 mL
10 mM 0.0237 mL 0.1184 mL 0.2368 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fuhlendorff J, et, al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6.

    [2]. Kokare DM, et, al. Interaction between neuropeptide Y and alpha-melanocyte stimulating hormone in amygdala regulates anxiety in rats. Brain Res. 2005 May 10;1043(1-2):107-14.

Neuropeptide S (human) (TFA)

发表于由

Neuropeptide S (human) (TFA);

Neuropeptide S human TFA，一种神经肽，是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human TFA 可用于阿尔茨海默病 (AD) 的研究。

Neuropeptide S (human) (TFA)amp;;

Neuropeptide S (human) (TFA) Chemical Structure

规格 是否有货
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生物活性

Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer’s disease (AD) research[1].

IC50 Target

EC50: 9.4 nM (neuropeptide S receptor)[1]
体外研究
(In Vitro)

Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively[1].
Neuropeptide S (human) (4 pM-1.7 nM; 48 hours) retains full agonist activity with an EC50 of 6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM)[1].
Neuropeptide S (human) (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS, [125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nM or 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice [1]
Dosage: 0.1 nM or 1 nM
Administration: Intracerebroventricular (i.c.v.) injection
Result: Increased locomotor activity and promoted wakefulness.

分子量

2301.52

Formula

C95H156N31F3O30S
Sequence

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
Sequence Shortening

SFRNGVGTGMKKTSFQRAKS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.