Neuropeptide Y (3-36) (human, rat)

发表于2023年8月7日由Whatman官网

Neuropeptide Y (3-36) (human, rat); 纯度: 95.28%

Neuropeptide Y (3-36) (human, rat) 是由二肽基肽酶4 (DPP4) 形成的神经肽Y (NPY) 代谢产物，是一种选择性 Y2 受体激动剂。Neuropeptide Y (3-36) (human, rat) 是由二肽基肽酶 4 (DPP4) 形成的 NPY 代谢产物。Neuropeptide Y (3-36) (human, rat) 通过 Y2 受体减少去甲肾上腺素的释放。

Neuropeptide Y (3-36) (human, rat) Chemical Structure

CAS No. : 150138-78-6

规格	价格	是否有货	数量
5 mg	￥3500	In-stock
10 mg	￥5500	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor^[1]^[2].

分子量

4011.50

Formula

C₁₇₅H₂₆₉N₅₃O₅₄S

CAS 号

150138-78-6

Sequence

Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

Sequence Shortening

SKPDNPGEDAPAEDMARYYSALRHYINLITRQRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (24.93 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2493 mL	1.2464 mL	2.4928 mL
5 mM	0.0499 mL	0.2493 mL	0.4986 mL
10 mM	0.0249 mL	0.1246 mL	0.2493 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (0.62 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (0.62 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (0.62 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (0.62 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Hubers SA, et al. DPP (Dipeptidyl Peptidase)-4 Inhibition Potentiates the Vasoconstrictor Response to NPY (Neuropeptide Y) in Humans During Renin-Angiotensin-Aldosterone System Inhibition. Hypertension. 2018;72(3):712-719.

[2]. Grandt D, et al. Neuropeptide Y 3-36 is an endogenous ligand selective for Y2 receptors. Regul Pept. 1996;67(1):33-37.

Neuropeptide W-23(human)(Synonyms: NPW-23)

发表于2023年7月25日由Whatman官网

Neuropeptide W-23(human);(Synonyms: NPW-23) 纯度: 95.02%

Neuropeptide W-23(human) 是 Neuropeptide W 的主要活性形式，为 NPBW1 和 NPBW2 的内源性配体。

Neuropeptide W-23(human)amp;;(Synonyms: NPW-23)

Neuropeptide W-23(human) Chemical Structure

CAS No. : 383415-79-0

规格	价格	是否有货	数量
1 mg	￥2200	In-stock
5 mg	￥9900	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Neuropeptide W-23(human), the active form of Neuropeptide W, is an endogenous ligand for NPBW1 and NPBW2.

体外研究
(In Vitro)

NPW-23 increases the I_Ca,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats^[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2583.02

Formula

C₁₂₀H₁₈₄N₃₄O₂₈S

CAS 号

383415-79-0

Sequence Shortening

WYKHVASPRYHTVGRAAGLMGL

中文名称

神经肽 W-23 (人)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42.

[2]. Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10.

Animal Administration ^[2]	Cardiovascular experiments are conducted the day after carotid implantation. On the day of the experiment, animals are habituated to a quiet room for at least 2 h. The carotid cannula is flushed with heparinized saline (200 U/mL in 0.9% NaCl) and connected to a pressure transducer. Baseline MAP is recorded for at least 30 min at 1-min intervals. For all experiments, preinjection baseline is calculated as the average MAP for 10 min before intracerebroventricular injections of saline or NPW-23. To test the cardiovascular effects of centrally administered NPW-23, rats are treated intracerebroventricularly with vehicle or vehicle containing 0.3, 1.0, or 3.0 nmol NPW-23. MAP is recorded for at least 45 min at 1-min intervals. To determine the potential role of sympathetic activation in mediating NPW-induced MAP increase, rats are pretreated intra-arterially with the α-adrenergic antagonist phentolamine-HCl (10 mg/kg body wt in 0.9% NaCl) or saline 15 min before central injection of saline or saline containing 1.0 nmol NPW-23. In a final experiment, the OX1R antagonist, SB-408124, or vehicle is injected intracerebroventricularly 15 s prior to 1.0 nmol NPW-23, and MAP is monitored for 45 min at 1-min intervals. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42. [2]. Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10.

Animal Administration
^[2]

Cardiovascular experiments are conducted the day after carotid implantation. On the day of the experiment, animals are habituated to a quiet room for at least 2 h. The carotid cannula is flushed with heparinized saline (200 U/mL in 0.9% NaCl) and connected to a pressure transducer. Baseline MAP is recorded for at least 30 min at 1-min intervals. For all experiments, preinjection baseline is calculated as the average MAP for 10 min before intracerebroventricular injections of saline or NPW-23. To test the cardiovascular effects of centrally administered NPW-23, rats are treated intracerebroventricularly with vehicle or vehicle containing 0.3, 1.0, or 3.0 nmol NPW-23. MAP is recorded for at least 45 min at 1-min intervals. To determine the potential role of sympathetic activation in mediating NPW-induced MAP increase, rats are pretreated intra-arterially with the α-adrenergic antagonist phentolamine-HCl (10 mg/kg body wt in 0.9% NaCl) or saline 15 min before central injection of saline or saline containing 1.0 nmol NPW-23. In a final experiment, the OX1R antagonist, SB-408124, or vehicle is injected intracerebroventricularly 15 s prior to 1.0 nmol NPW-23, and MAP is monitored for 45 min at 1-min intervals.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42.

[2]. Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10.

Neuropeptide Y Y1 receptor antagonist 1

发表于2023年7月21日由Whatman官网

Neuropeptide Y Y1 receptor antagonist 1;

Neuropeptide Y Y1 receptor antagonist 1 (化合物 39)，一种荧光探针，是神经肽 Y Y¹ 受体 (Y¹R) 的拮抗剂，K_i 值为 0.19 nM。

Neuropeptide Y Y1 receptor antagonist 1 Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y¹ receptor (Y¹R), with a K_i of 0.19 nM^[1].

IC₅₀ Target^[1]

NPY Y₁ receptor

0.19 nM (Ki)

分子量

1115.28

Formula

C₆₂H₇₀N₁₀O₁₀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Müller C, et, al. Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y 1 Receptor. J Med Chem. 2022 Mar 24;65(6):4832-4853.

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA

发表于2023年7月15日由Whatman官网

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA; 纯度: 99.38%

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 是一种特定的神经肽 Y Y₁ 受体激动剂。[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 也激活 Y₄，Y₅。[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 可以增加麻醉大鼠的血压，也增加饮食摄入量。

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFAamp;;

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA Chemical Structure

规格	价格	是否有货	数量
5 mg	￥4000	In-stock
10 mg	￥6800	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake^[1]^[2].

IC₅₀ Target^[1]^[2]

NPY Y₁ receptor

;

NPY Y₄ receptor

;

NPY Y₅ receptor

;

体外研究
(In Vitro)

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has K_i values of 0.39 nM, 0.499 nM, 0.31 nM for Y₁, Y₄, Y₅ in HEK cell lines. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has a K_i of >1000 for Y₂ in HEK cell lines^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4354.76

Formula

C₁₉₁H₂₈₅F₃N₅₄O₅₈S

Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

H₂O : 50 mg/mL (11.48 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2296 mL	1.1482 mL	2.2963 mL
5 mM	0.0459 mL	0.2296 mL	0.4593 mL
10 mM	0.0230 mL	0.1148 mL	0.2296 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y₅-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58.

[2]. J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y₁ receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6.

[3]. A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y₁-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15.

Neuropeptide FF(Synonyms: NPFF)

发表于2023年6月29日由Whatman官网

Neuropeptide FF;(Synonyms: NPFF) 纯度: 99.83%

Neuropeptide FF (NPFF)，是一种属于RF-酰胺类家族的八肽，与两种不同的 G 蛋白偶联受体 NPFF(1) 和 NPFF(2) 相互作用，在脑内具有多种生理功能，包括中枢心血管和神经内分泌调节。

Neuropeptide FF Chemical Structure

CAS No. : 99566-27-5

规格	价格	是否有货	数量
1 mg	￥1500	In-stock
5 mg	￥5200	In-stock
10 mg	￥8800	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Neuropeptide FF 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Anti-Cardiovascular Disease Compound Library
Peptide Library

生物活性

Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation^[1]^[2].

分子量

1081.27

Formula

C₅₄H₇₆N₁₄O₁₀

CAS 号

99566-27-5

Sequence

Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2

Sequence Shortening

FLFQPQRF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (92.48 mM; Need ultrasonic)

H₂O : 50 mg/mL (46.24 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9248 mL	4.6242 mL	9.2484 mL
5 mM	0.1850 mL	0.9248 mL	1.8497 mL
10 mM	0.0925 mL	0.4624 mL	0.9248 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.31 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.31 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.31 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Mankus JV, et al. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Med Chem. 2012 Jun;4(9):1085-92.

[2]. Jhamandas JH, et al. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8.

RFRP-3(human)(Synonyms: Neuropeptide VF(124-131)(human))

发表于2023年6月22日由Whatman官网

RFRP-3(human);(Synonyms: Neuropeptide VF(124-131)(human)) 纯度: 98.51%

RFRP-3 (Neuropeptide VF(124-131))(human)，一种人GnIH 肽同源物，是一种促性腺激素分泌抑制 Ca²⁺ 动员的有效抑制剂。RFRP-3(human) 是一种NPFF1 受体激动剂，它抑制 forskolin (HY-15371) 诱导的 cAMP 生成的 IC₅₀ 值为 0.7 nM。

RFRP-3(human)amp;;(Synonyms: Neuropeptide VF(124-131)(human))

RFRP-3(human) Chemical Structure

CAS No. : 311309-27-0

规格	价格	是否有货	数量
1 mg	￥1400	In-stock
5 mg	￥4900	In-stock
10 mg	￥7800	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM^[1].

体外研究
(In Vitro)

RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM^[1].
Scatchard-plot analysis shows that ¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_d value and the B_max values are 0.19 nM and 1.3 pM, respectively.
RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM)^[1].
RFRP-3 (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

969.14

Formula

C₄₅H₇₂N₁₄O₁₀

CAS 号

311309-27-0

Sequence Shortening

VPNLPQRF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : ≥ 100 mg/mL (103.18 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0318 mL	5.1592 mL	10.3184 mL
5 mM	0.2064 mL	1.0318 mL	2.0637 mL
10 mM	0.1032 mL	0.5159 mL	1.0318 mL

参考文献

[1]. Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology

Neuropeptide Y(29-64)

发表于2023年4月13日由Whatman官网

Neuropeptide Y(29-64); 纯度: 98.42%

Neuropeptide Y(29-64) 是由 36 个氨基酸组成的多肽，为神经肽 Y 的一个片段。

Neuropeptide Y(29-64) Chemical Structure

CAS No. : 303052-45-1

规格	价格	是否有货	数量
1 mg	￥1500	In-stock
5 mg	￥6000	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

Neuropeptide Y(29-64) 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Neuronal Signaling Compound Library
Endocrinology Compound Library
Neurotransmitter Receptor Compound Library
Anti-Obesity Compound Library

生物活性

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

体外研究
(In Vitro)

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4272.70

Formula

C₁₈₉H₂₈₄N₅₄O₅₈S

CAS 号

303052-45-1

Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr

Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 16.67 mg/mL (3.90 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2340 mL	1.1702 mL	2.3404 mL
5 mM	—	—	—
10 mM	—	—	—

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 1.67 mg/mL (0.39 mM); Clear solution

此方案可获得 ≥ 1.67 mg/mL (0.39 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.67 mg/mL (0.39 mM); Clear solution

此方案可获得 ≥ 1.67 mg/mL (0.39 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 1.67 mg/mL (0.39 mM); Clear solution

此方案可获得 ≥ 1.67 mg/mL (0.39 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

[D-Trp34]-Neuropeptide Y TFA

发表于2023年3月2日由Whatman官网

[D-Trp34]-Neuropeptide Y TFA;

[D-Trp34]-Neuropeptide Y TFA 是有效的，选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y TFA 在 NPY Y₁，Y₂，Y₄ 和 y₆ 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y TFA 明显增加大鼠的食物摄入量。

[D-Trp34]-Neuropeptide Y TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats^[1]^[2].

IC₅₀ Target^[1]

NPY Y₅ receptor

;

体外研究
(In Vitro)

[D-Trp34]-Neuropeptide Y TFA has pK_i values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY₁, hY₂, hY₄, hY₅, rY₁, rY₂, rY₄, rY₅ in CHO cells. [D-Trp34]-Neuropeptide Y TFA has pEC₅₀ values of 6.44, <6, 6.28，7.82 for rY₁, rY₂ in CHO cells and rY₄, rY₅ in HEK-293 cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

[D-Trp34]-Neuropeptide Y TFA (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2466.76

Formula

C₁₁₂H₁₇₁F₃N₃₄O₂₆

Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9.

[2]. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y₅ receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4.

[D-Arg25]-Neuropeptide Y (human)

发表于2023年3月2日由Whatman官网

[D-Arg25]-Neuropeptide Y (human);

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是 Y₁ 受体的选择性激动剂。Neuropeptide Y (human) 和阿尔兹海默症相关，能够保护老鼠皮质神经元对抗淀粉样蛋白毒性。

[D-Arg25]-Neuropeptide Y (human) Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer’s disease (AD) and protects rat cortical neurons against β-Amyloid toxicity^[1].
体外研究 (In Vitro)	[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	4271.68
Formula	C₁₈₉H₂₈₅N₅₅O₅₇S
Sequence Shortening	YPSKPDNPGEDAPAEDMARYYSAL-{D-Arg}-HYINLITRQRY-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kilian Kuhn, et al. Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonists. zur Erlangung des Doktorgrades der Naturwissenschaften an der Fakultät für Chemie und Pharmazie der Universität Regensburg. [2]. Li-Ying Fu, et al. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004 Oct 6;24(40):8741-51. [3]. Ambikaipakan Balasubramaniam, et al. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr Pharm Des. 2003;9(15):1165-75.

Neuropeptide S(Mouse)

发表于2023年2月24日由Whatman官网

Neuropeptide S(Mouse);

Neuropeptide S (Mouse) 是一种生物活性肽。Neuropeptide S (Mouse) 作为 20 个氨基酸的神经递质/神经调节因子，可用于觉醒、焦虑、运动、进食行为、记忆和药物成瘾的研究。

Neuropeptide S(Mouse) Chemical Structure

CAS No. : 412938-74-0

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and drug addiction^[1].
分子量	2182.47
Formula	C₉₃H₁₅₆N₃₄O₂₇
CAS 号	412938-74-0
Sequence Shortening	SFRNGVGSGAKKTSFRRAKQ
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Peng YL, et al. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-1883.

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标签归档：neuropeptide

Neuropeptide Y (3-36) (human, rat)

Neuropeptide W-23(human)(Synonyms: NPW-23)

Neuropeptide Y Y1 receptor antagonist 1

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 相关产品

bull;相关化合物库:

Neuropeptide FF(Synonyms: NPFF)

Neuropeptide FF 相关产品

bull;相关化合物库:

RFRP-3(human)(Synonyms: Neuropeptide VF(124-131)(human))

Neuropeptide Y(29-64)

Neuropeptide Y(29-64) 相关产品

bull;相关化合物库:

[D-Trp34]-Neuropeptide Y TFA

[D-Arg25]-Neuropeptide Y (human)

Neuropeptide S(Mouse)