标签归档：nfat

11R-VIVIT

发表于由

11R-VIVIT;

11R-VIVIT 是一种活化 T 细胞的细胞通透性核因子 (NFAT) 抑制剂。11R-VIVIT 可用于足细胞和糖尿病肾病的研究。

11R-VIVITamp;;

11R-VIVIT Chemical Structure

CAS No. : 592517-80-1

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1 mg 询价

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生物活性

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy[1].

IC50 Target

NFAT[1]
体外研究
(In Vitro)

11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3573.15

Formula

C147H259N67O36S
CAS 号

592517-80-1
Sequence Shortening

RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang L, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170(2):426-439.

NFAT Inhibitor-1(Synonyms: VIVIT peptide)

发表于由

NFAT Inhibitor-1;(Synonyms: VIVIT peptide) 纯度: 98.89%

NFAT Inhibitor (VIVIT peptide) 是一种 NFAT 的细胞渗透性肽抑制剂，可选择性抑制钙调磷酸酶介导的 NFAT 脱磷酸作用。

NFAT Inhibitor-1amp;;(Synonyms: VIVIT peptide)

NFAT Inhibitor-1 Chemical Structure

CAS No. : 249537-73-3

规格 价格 是否有货 数量
1 mg ￥700 In-stock
5 mg ￥2800 In-stock
10 mg ￥5100 In-stock
25 mg ￥9900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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NFAT Inhibitor-1 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

IC50 Target

Nuclear factor of activated Tcells (NFAT)[1][2]
体外研究
(In Vitro)

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Human peripheral blood CD14+ monocytes
Concentration: 10 μM
Incubation Time: 24 hours or 21 days
Result: Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.

分子量

1685.94

Formula

C75H120N20O22S
CAS 号

249537-73-3
Sequence

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
Sequence Shortening

MAGPHPVIVITGPHEE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (59.31 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5931 mL 2.9657 mL 5.9314 mL
5 mM 0.1186 mL 0.5931 mL 1.1863 mL
10 mM 0.0593 mL 0.2966 mL 0.5931 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33.

    [2]. Ma JD, et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264.