Nisin

Nisin;

Nisin 是由一组属于乳球菌和链球菌属的革兰氏阳性菌产生的乳酸链球菌肽。

Nisinamp;;

Nisin Chemical Structure

CAS No. : 1414-45-5

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Nisin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species.

体外研究
(In Vitro)

Nisin is classified as a Type A (I) lantibiotic that is synthesized from mRNA and the translated peptide contains several unusual amino acids due to post-translational modifications. Nisin is an antimicrobial peptide produced by certain Gram-positive bacteria that include Lactococcus and Streptococcus species[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

3354.07

Formula

C143H230N42O37S7

CAS 号

1414-45-5

Sequence

Ile-{Abu}-{d-Cys}-Ile-Ala-Leu-Cys-{d-Abu}-Pro-Gly-Cys-Lys-{d-Abu}-Gly-Ala-Leu-Met-Gly-Cys-Asn-Met-Lys-{d-Abu}-Ala-{d-Abu}-Cys-His-Cys-Ser-Ile-His-Val-Ala-Lys (Disulfide bridge: Cys3-Cys7, Abu8-Cys11, Abu13-Cys19, Abu23-Cys26, Abu25-Cys28)

Sequence Shortening

I-{Abu}-{d-Cys}-IALC-{d-Abu}-PGCK-{d-Abu}-GALMGCNML-{d-Abu}-A-{d-Abu}-CHCSIHVAK (Disulfide bridge: Cys3-Cys7, Abu8-Cys11, Abu13-Cys19, Abu23-Cys26, Abu25-Cys28)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 1 mg/mL (0.30 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;adjust pH to 3 with HCl) (insoluble)

参考文献
  • [1]. Shin JM, et al. Biomedical applications of nisin. J Appl Microbiol. 2016 Jun;120(6):1449-65.