[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA;

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA 是具有高度选择性的 NK2 受体激动剂,其 IC50 值为 6.1 nM。

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFAamp;;

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM[1].

分子量

918.01

Formula

C41H66F3N9O11

Sequence Shortening

DKFVG{N(Me)Leu}{Nle}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. G Chassaing, et al. Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides. 1991 Jun;19(2):91-5.

    [2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

Ac-Nle-Pro-Nle-Asp-AMC

Ac-Nle-Pro-Nle-Asp-AMC;

Ac-Nle-Pro-Nle-Asp-AMC 是 26S 蛋白酶体 (26S proteasome) 的特异性底物。Ac-Nle-Pro-Nle-Asp-AMC 可用于 26S 蛋白酶体 caspase 样活性分析。

Ac-Nle-Pro-Nle-Asp-AMCamp;;

Ac-Nle-Pro-Nle-Asp-AMC Chemical Structure

CAS No. : 355140-49-7

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生物活性

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].

分子量

655.74

Formula

C33H45N5O9

CAS 号

355140-49-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410(1):131-40.

    [2]. Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8(2):e57112.

    [3]. Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730.

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) 是一种甲酰肽受体 (FPR) 激动剂。

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFAamp;;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA Chemical Structure

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100 mg ; 询价 ;
250 mg ; 询价 ;
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N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA 的其他形式现货产品:

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys

生物活性

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist[1].

IC50 Target

Formyl peptide receptor[1]

分子量

938.04

Formula

C45H66F3N7O11

Sequence

N-Formyl-{NLE}-Leu-Phe-{NLE}-Tyr-Lys

Sequence Shortening

N-Formyl-{NLE}-LF-{NLE}-YK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Stenfeldt AL, et al. The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptidereceptor but not the formyl peptide receptor like 1. Biochem Pharmacol. 2007 Oct 1;74(7):1050-6.

[Lys5,MeLeu9,Nle10]-NKA(4-10)

[Lys5,MeLeu9,Nle10]-NKA(4-10);

[Lys5,MeLeu9,Nle10]-NKA(4-10) 是具有高度选择性的 NK2 受体激动剂,其 IC50 值为 6.1 nM。

[Lys5,MeLeu9,Nle10]-NKA(4-10)amp;;

[Lys5,MeLeu9,Nle10]-NKA(4-10) Chemical Structure

CAS No. : 137565-28-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM[1].

分子量

803.99

Formula

C39H65N9O9

CAS 号

137565-28-7

Sequence Shortening

DKFVG{N(Me)Leu}{Nle}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. G Chassaing, et al. Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides. 1991 Jun;19(2):91-5.

    [2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

[Nle11]-Substance P

[Nle11]-Substance P;

[Nle11]-Substance P 是物质 P 类似物,避免了甲硫氨酸氧化问题。

[Nle11]-Substance Pamp;;

[Nle11]-Substance P Chemical Structure

CAS No. : 57462-42-7

规格 价格 是否有货
1 mg ¥600 询问价格 货期
5 mg ¥1800 询问价格 货期
10 mg ¥3100 询问价格 货期

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生物活性

[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

体外研究
(In Vitro)

Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1329.59

Formula

C64H100N18O13

CAS 号

57462-42-7

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-{NLE}-NH2

Sequence Shortening

RPKPQQFFGL-{NLE}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202.

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH) 纯度: 98.64%

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) 是一种甲酰肽受体 (FPR) 激动剂。

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lysamp;;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys Chemical Structure

CAS No. : 71901-21-8

规格 价格 是否有货 数量
5 mg ¥950 In-stock
10 mg ¥1450 In-stock
25 mg ¥2450 In-stock
50 mg ¥3400 In-stock
100 mg ¥4900 询价
200 mg ; 询价 ;
500 mg ; 询价 ;

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N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Peptide Library

生物活性

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist[1].

分子量

824.02

Formula

C43H65N7O9

CAS 号

71901-21-8

Sequence

N-Formyl-{NLE}-Leu-Phe-{NLE}-Tyr-Lys

Sequence Shortening

N-Formyl-{NLE}-LF-{NLE}-YK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 16.67 mg/mL (20.23 mM; ultrasonic and adjust pH to 12 with NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2136 mL 6.0678 mL 12.1356 mL
5 mM 0.2427 mL 1.2136 mL 2.4271 mL
10 mM 0.1214 mL 0.6068 mL 1.2136 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Stenfeldt AL, et al. The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptidereceptor but not the formyl peptide receptor like 1. Biochem Pharmacol. 2007 Oct 1;74(7):1050-6.