荧光染料Indo-1 AM(Synonyms: Indo-1 Acetoxymethyl ester)

发表于2024年4月25日由Whatman官网

荧光染料Dye Reagents Indo-1 AM;(Synonyms: Indo-1 Acetoxymethyl ester)

Indo-1 AM 是一种荧光 Ca²⁺ 指示剂 (λ_ex=340 nm，λ_em=405/485 nm)。

Indo-1 AM Chemical Structure

CAS No. : 112926-02-0

规格	价格	是否有货
1 mg	￥6151	询问价格货期

* Please select Quantity before adding items.

生物活性	Indo-1 AM is a fluorescent Ca²⁺ indicator (λ_ex=340 nm, λ_em=405/485 nm).
体外研究 (In Vitro)	Indo-1 AM is a fluorescent Ca²⁺ indicator with λ_ex=340 nm and λ_em=405/485 nm^[1]. In rabbit hearts that are exposed to Indo-1 AM, 72% of the dye is in the cytosol, and the remainder is associated with the mitochondria, microsomes and the nucleus^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1009.91
Formula	C₄₇H₅₁N₃O₂₂
CAS 号	112926-02-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Andrienko T, et al. Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning. PLoS One. 2016 Dec 1;11(12):e0167300. [2]. Blatter LA, et al. Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2. Biophys J. 1990 Dec;58(6):1491-9.

Cell Assay ^[2]	The cells are loaded with indo-I and fura-2 by exposure to the membrane-permeant forms, Indo-1 AM (indo-l-acetoxymethyl ester) and fura-2-acetoxymethyl ester, respectively. A mixture of 10 μL of 1 mM Indo-1 AM or fura-2/AM in dimethylsulfoxide (DMSO), 2.5 μL of 25% wt/wt Pluronic F-127 in DMSO, and 75 μL fetal calf serum (FCS) or newborn calf serum (NCS) is added to 2 mL Tyrode solution containing the cells and 40 μL FCS or NCS. Loading is achieved by gently shaking the cells for 15 to 30 min^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Andrienko T, et al. Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning. PLoS One. 2016 Dec 1;11(12):e0167300. [2]. Blatter LA, et al. Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2. Biophys J. 1990 Dec;58(6):1491-9.

Cell Assay
^[2]

The cells are loaded with indo-I and fura-2 by exposure to the membrane-permeant forms, Indo-1 AM (indo-l-acetoxymethyl ester) and fura-2-acetoxymethyl ester, respectively. A mixture of 10 μL of 1 mM Indo-1 AM or fura-2/AM in dimethylsulfoxide (DMSO), 2.5 μL of 25% wt/wt Pluronic F-127 in DMSO, and 75 μL fetal calf serum (FCS) or newborn calf serum (NCS) is added to 2 mL Tyrode solution containing the cells and 40 μL FCS or NCS. Loading is achieved by gently shaking the cells for 15 to 30 min^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Andrienko T, et al. Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning. PLoS One. 2016 Dec 1;11(12):e0167300.

[2]. Blatter LA, et al. Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2. Biophys J. 1990 Dec;58(6):1491-9.

荧光染料ADHP(Synonyms: 10-Acetyl-3,7-dihydroxyphenoxazine)

发表于2024年4月24日由Whatman官网

荧光染料Dye Reagents ADHP;(Synonyms: 10-Acetyl-3,7-dihydroxyphenoxazine)

ADHP 是一种荧光过氧化物酶底物（λ_ex=530 nm, λ_em=590 nm）。

ADHP Chemical Structure

CAS No. : 119171-73-2

规格	价格	是否有货
5 mg	￥2200	询问价格货期

* Please select Quantity before adding items.

生物活性	ADHP is a fluorogenic peroxidase substrate (λ_ex=530 nm, λ_em=590 nm).
体外研究 (In Vitro)	To obtain the parameters K_m and k_cat for Compound I, two independent methods are used. Initially, the oxidation of ADHP using the injector functionality built-in to the fluorescence plate reader is studied. The auto-injector dispenses the H₂O₂ to initiate the reaction, as a means of generating a set of progress curves. Analysis for MPO-mediated oxidation of ADHP gives a K_m of 31±4 μM and the k_cat of 186± 6 s⁻¹.The k_obs also increases over the experimental range of ADHP concentrations from 1 to 80 μM and for the converse experiment holding substrate constant over 3 to 45 nM MPO. The apparent second order rate constant obtain from the slope of k_obs against ADHP concentration K^app_on is 2.1±0.2 mM/s^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	257.24
Formula	C₁₄H₁₁NO₄
CAS 号	119171-73-2
中文名称	10-乙酰基-3,7-二羟基吩嗪
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Jiansheng Huang, et al. Ordered Cleavage of Myeloperoxidase Ester Bonds Releases Active site Heme Leading to Inactivation of Myeloperoxidase by Benzoic Acid Hydrazide Analogs. Arch Biochem Biophys. 2014 Apr 15; 548: 74–85.

Kinase Assay ^[1]	ADHP, 4-ABAH, 2-ABAH, 4-BAH, 4-FBAH, 4-NBAH, 4-TFMBAH, 3-DMABAH, NaN₃ and isoniazid are dissolved in DMSO and subsequently diluted into assay buffer. The final concentration of DMSO in the reaction is less than 0.5 % (v/v), which does not affect fluorescence of the oxidized ADHP product 7-hydroxyl-3H-phenoxazin-3-one (resorufin). Reactions of ADHP (20 μM) are incubated with MPO (2.8 nm) in assay buffer and initiated by the addition of 1/10th volume H₂O₂ from a serial dilution basin. To determine the effect that the simplest benzoic acid hydrazide inhibitor or its analog 4-TFMBAH has on the heme catalytic ability of MPO, MPO (1.2 μM) is incubated for 10 min with different concentrations of BAH inhibitor (0, 0.025, 0.25, 2.5, 12.5 and 25 mM) with ADHP (40 μM) and timing of the reaction is measured following addition of H₂O₂ (20 μM) ADHP. All reactions are measured in assay buffer at room temperature. Samples of 20 μL are added to non-reducing sample loading buffers, and then loaded without prior heating and resolved by 4-15% gradient SDS-polyacrylamide gel electrophoresis^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Jiansheng Huang, et al. Ordered Cleavage of Myeloperoxidase Ester Bonds Releases Active site Heme Leading to Inactivation of Myeloperoxidase by Benzoic Acid Hydrazide Analogs. Arch Biochem Biophys. 2014 Apr 15; 548: 74–85.

Kinase Assay
^[1]

ADHP, 4-ABAH, 2-ABAH, 4-BAH, 4-FBAH, 4-NBAH, 4-TFMBAH, 3-DMABAH, NaN₃ and isoniazid are dissolved in DMSO and subsequently diluted into assay buffer. The final concentration of DMSO in the reaction is less than 0.5 % (v/v), which does not affect fluorescence of the oxidized ADHP product 7-hydroxyl-3H-phenoxazin-3-one (resorufin). Reactions of ADHP (20 μM) are incubated with MPO (2.8 nm) in assay buffer and initiated by the addition of 1/10th volume H₂O₂ from a serial dilution basin. To determine the effect that the simplest benzoic acid hydrazide inhibitor or its analog 4-TFMBAH has on the heme catalytic ability of MPO, MPO (1.2 μM) is incubated for 10 min with different concentrations of BAH inhibitor (0, 0.025, 0.25, 2.5, 12.5 and 25 mM) with ADHP (40 μM) and timing of the reaction is measured following addition of H₂O₂ (20 μM) ADHP. All reactions are measured in assay buffer at room temperature. Samples of 20 μL are added to non-reducing sample loading buffers, and then loaded without prior heating and resolved by 4-15% gradient SDS-polyacrylamide gel electrophoresis^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Jiansheng Huang, et al. Ordered Cleavage of Myeloperoxidase Ester Bonds Releases Active site Heme Leading to Inactivation of Myeloperoxidase by Benzoic Acid Hydrazide Analogs. Arch Biochem Biophys. 2014 Apr 15; 548: 74–85.

Cy7.5

发表于2024年4月21日由Whatman官网

Cy7.5;

Cy7.5 是一种荧光标记试剂 (Ex=700-770 nm，Em=790 nm)。Cyanine 染料可用于标记蛋白质，抗体，肽，寡聚核苷酸等。

Cy7.5 Chemical Structure

CAS No. : 847180-48-7

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Cy7.5 is a fluorescence imaging (FI) agent (Ex=700-770 nm，Em=790 nm) as well as a magnetic resonance imaging (MRI) imaging agent. Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotide^[1].

分子量

943.09

Formula

C₄₃H₄₆N₂O₁₄S₄

CAS 号

847180-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:;

DMSO : 62.5 mg/mL (66.27 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0603 mL	5.3017 mL	10.6034 mL
5 mM	0.2121 mL	1.0603 mL	2.1207 mL
10 mM	0.1060 mL	0.5302 mL	1.0603 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.08 mg/mL (2.21 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (2.21 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (2.21 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (2.21 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Zhan Y, et al. In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles. Molecules. 2017 Dec 12;22(12). pii: E2208.

Research Diets动物饲料98121701NM Formula 模型饲料配方表

发表于2024年4月20日由Whatman官网

上海金畔生物科技有限公司代理Research Diets品牌动物饲料全线产品，欢迎访问官网了解更多产品信息。
Research Diets动物饲料98121701NM Formula 模型饲料配方表

98121701NM

RD Low Fat Diet Without Cholesterol

适用实验动物模型: 啮齿类 (大鼠/小鼠)
饲料颜色: 未添加染色剂

是否辐照处理/辐照产品号码 :

Research Diets生产饲料大部分都可以送伽马辐照。我们会在这类的产品号结尾标注 “i” 字母以说明其为通过辐照处理的饲料，而饲料经过多轮辐照处理则会标示双字母 “ii” 以区别单轮辐照 “i”。如果您有任何关于辐照的问题，请联系我们的科研技术支持。

无

纯化饲料配方表

营养成分类别	成分	公克
蛋白质	酪蛋白（乳酸; 30筛孔）	195.00 克
蛋白质	Methionine, DL	3.00 克
碳水化合物	玉米淀粉	404.40 克
碳水化合物	蔗糖(微粒)	341.00 克
碳水化合物	麦芽糊精	100.00 克
纤维素	纤维素(Solka Floc/FCC200)	50.00 克
脂肪	玉米油	52.50 克
矿物质	S10001	35.00 克
矿物质	碳酸钙, light(USP)	4.00 克
维他命	V10001	10.00 克
维他命	酒石酸胆碱	2.00 克
抗氧化剂	Ethoxyquin	0.04 克
	饲料配方总重（公克）:	1196.94 克

饲料营养素热量组成 Physiological Fuel Values

蛋白质:	17 % 千卡
脂肪:	10 % 千卡
碳水化合物:	73 % 千卡
饲料能量密度:	3.88 千卡/每克

DiBAC4(3)

发表于2024年4月17日由Whatman官网

DiBAC4(3); 纯度: ge;98.0%

DiBAC4(3) 是一种电压敏感的荧光染料 (λ_ex=490 nm，λ_em=505 nm)。

DiBAC4(3) Chemical Structure

CAS No. : 70363-83-6

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥4880	In-stock
25 mg	￥3700	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

DiBAC4(3) 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus

生物活性

DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).

体外研究
(In Vitro)

The membrane hyperpolarization induced by 10 μM Evans blue (EB) in HEKBKα is clearly observed with DiBAC4(3), while the change in membrane potential (MP) by addition of 3 mM tetraethylammonium chloride (TEA) appears more slowly than that measured with microelectrode. The time to peak of hyperpolarization is 2.3±0.9 s (n=4) and 35.0±2.6 s (n=12, P<0.01) by the measurements with microelectrodes and DiBAC4(3), respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

516.63

Formula

C₂₇H₄₀N₄O₆

CAS 号

70363-83-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据

In Vitro:;

DMSO : ≥ 60 mg/mL (116.14 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9356 mL	9.6781 mL	19.3562 mL
5 mM	0.3871 mL	1.9356 mL	3.8712 mL
10 mM	0.1936 mL	0.9678 mL	1.9356 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Yamada A, et al. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells. Jpn J Pharmacol. 2001 Jul;86(3):342-50.

Cell Assay ^[1]	Prior to the fluorescence measurements, cells are incubated in KRH (Krebs-Ringer-HEPES) buffer containing with 100 nM DiBAC4(3) for 20 min at room temperature. The stained cells are used for experiments without washing. The fluorescence emission is collected using a 505 nm dicroic mirror and a BA filter (>520 nm)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yamada A, et al. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells. Jpn J Pharmacol. 2001 Jul;86(3):342-50.

Cell Assay
^[1]

Prior to the fluorescence measurements, cells are incubated in KRH (Krebs-Ringer-HEPES) buffer containing with 100 nM DiBAC4(3) for 20 min at room temperature. The stained cells are used for experiments without washing. The fluorescence emission is collected using a 505 nm dicroic mirror and a BA filter (>520 nm)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Yamada A, et al. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells. Jpn J Pharmacol. 2001 Jul;86(3):342-50.

DDAO

发表于2024年4月13日由Whatman官网

DDAO; 纯度: 98.07%

DDAO 是一种有潜在用途的近红外 (NIR) 红色荧光探针，具有可调的激发波长 (600-650 nm) 和长发射波长 (λem = 656 nm)。DDAO 可以用于检测不同酶的活性，例如 β-半乳糖苷酶，硫酸酯酶，蛋白质磷酸酶 2A，羧酸酯酶 2，人白蛋白和酯酶。

DDAO Chemical Structure

CAS No. : 118290-05-4

规格	价格	是否有货	数量
Free Sample (0.1-0.5 mg)	;	Apply now	;
10;mM;*;1 mL in DMSO	￥550	In-stock
10 mg	￥500	In-stock
25 mg	￥900	In-stock
50 mg	￥1500	In-stock
100 mg	￥2500	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

DDAO 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Anti-Cancer Compound Library

生物活性

DDAO is a promising near-infrared (NIR) red fluorescent probe with tunable excitation wavelength (600-650 nm) and long emission wavelength (λem = 656 nm). DDAO can de desiged for detection of the activities of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterases^[1].

IC₅₀ Target

Red fluorescent probe

分子量

308.16

Formula

C₁₅H₁₁Cl₂NO₂

CAS 号

118290-05-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 10.42 mg/mL (33.81 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2451 mL	16.2253 mL	32.4507 mL
5 mM	0.6490 mL	3.2451 mL	6.4901 mL
10 mM	0.3245 mL	1.6225 mL	3.2451 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: 1.04 mg/mL (3.37 mM); Suspended solution; Need ultrasonic

此方案可获得 1.04 mg/mL (3.37 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 10.4 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: 1.04 mg/mL (3.37 mM); Suspended solution; Need ultrasonic

此方案可获得 1.04 mg/mL (3.37 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 10.4 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Hou J1, et al. A near-infrared ratiometric/turn-on fluorescent probe for in vivo imaging of hydrogen peroxide in a murine model of acute inflammation.Anal Chim Acta. 2018 Sep 18;1024:169-176.

FD-1080

发表于2024年4月12日由Whatman官网

FD-1080;

FD-1080 是在 NIR-II 区域中具有激发和发射光的荧光团 (Ex=1064 nm, Em=1080 nm)，可用于体内成像。

FD-1080 Chemical Structure

CAS No. : 1151666-58-8

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging^[1].
体外研究 (In Vitro)	FD-1080 shows superior photostability under the continuous laser irradiation. The quantum yield of FD-1080 is 0.31%, and can be increased to 5.94% after combining with fetal bovine serum (FBS) to form FD-1080-FBS complexes^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	The 1064 nm NIR-II excitation of FD-1080 is demonstrated with the high tissue penetration depth and superior imaging resolution compared to NIR excitation from 650 nm to 980 nm. Deeptissue and high-resolution in vivo imaging for the left hindlimb vasculature, abdomen, and brain vessels was realized, allowing penetration through intact skin, tissue, and skull. FD-1080 also quantifying the respiratory rate based on the dynamic imaging of respiratory craniocaudal motion of the liver for the awake and anaesthetized mouse^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	765.31
Formula	C₄₀H₃₈ClN₂NaO₆S₂
CAS 号	1151666-58-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Benhao Li, et al. An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging. Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7483-7487.

Nordic-MUbio N125M Mouse anti Human Rb (Retinoblastoma) 100 µg

发表于2024年4月2日由Whatman官网

上海金畔生物科技有限公司提供Nordic-MUbio N125M Mouse anti Human Rb (Retinoblastoma) 100 µg，欢迎访问官网了解更多产品信息和订购

品牌货号产品名称规格价格

Nordic-MUbio N125M Mouse anti Human Rb (Retinoblastoma) 100 µg 4179.00

Nordic-MUbio N120M Mouse anti Human Rb (Retinoblastoma) 100 µg 4179.00

Nordic-MUbio N115M Mouse anti Human myc 100 µg 4179.00

Nordic-MUbio N110M Mouse anti Human myc 100 µg 4179.00

Nordic-MUbio N105P Sheep anti Human Rhombotin 2 250 µg 4179.00

Nordic-MUbio N105M Mouse anti Human p130 100 µg 4179.00

Nordic-MUbio N100P Sheep anti Human Psoriasin (S-100 homolog) 250 µg 4179.00

Nordic-MUbio N100M Mouse anti Human p107 100 µg 4179.00

Nordic-MUbio M100P Sheep anti Human HER2/neu 250 µg 4179.00

Nordic-MUbio L146M Mouse anti Human NGF (Nerve Growth Factor) 500 µg 4767.00

Nordic-MUbio L115P Sheep anti Avian TGF beta II receptor (77-148) 100 µg 4179.00

Nordic-MUbio L110P Sheep anti Chicken TGF beta II receptor (27-85) 50 µg 4179.00

Nordic-MUbio L105P Rabbit anti Human, Mouse Interferon (includes alpha 1 and 2a) 100 µg 4179.00

Nordic-MUbio K140P Sheep anti Mouse p38 HOG Kinase 250 µg 4179.00

Nordic-MUbio K135P Sheep anti Mouse SAP kinase 250 µg 4179.00

Nordic-MUbio K130P Sheep anti Mouse ERK1 + ERK2 250 µg 4179.00

Nordic-MUbio K115P Sheep anti Human Guanalyate Kinase GKWW domain (MAGI) 250 µg 4179.00

Nordic-MUbio K110P Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI) 250 µg 4179.00

Nordic-MUbio K105P Sheep anti Human Vesicle Associated Membrane Protein (VAMP 1/2) 250 µg 4179.00

Nordic-MUbio K100P Sheep anti Human chk 1 kinase 250 µg 4179.00

Exalpha N135M Mouse anti Human Rb (Retinoblastoma) 100 µg

发表于2024年3月27日由Whatman官网

上海金畔生物科技有限公司提供Exalpha N135M Mouse anti Human Rb (Retinoblastoma) 100 µg，欢迎访问官网了解更多产品信息和订购

品牌货号产品名称规格价格

Exalpha N135M Mouse anti Human Rb (Retinoblastoma) 100 µg 4179.00

Exalpha N130M Mouse anti Human Rb (Retinoblastoma) 100 µg 4179.00

Exalpha N125M Mouse anti Human Rb (Retinoblastoma) 100 µg 4179.00

Exalpha N120M Mouse anti Human Rb (Retinoblastoma) 100 µg 4179.00

Exalpha N115M Mouse anti Human myc 100 µg 4179.00

Exalpha N110M Mouse anti Human myc 100 µg 4179.00

Exalpha N105P Sheep anti Human Rhombotin 2 250 µg 4179.00

Exalpha N105M Mouse anti Human p130 100 µg 4179.00

Exalpha N100P Sheep anti Human Psoriasin (S-100 homolog) 250 µg 4179.00

Exalpha N100M Mouse anti Human p107 100 µg 4179.00

Exalpha M100P Sheep anti Human HER2/neu 250 µg 4179.00

Exalpha L146M Mouse anti Human NGF (Nerve Growth Factor) 500 µg 4767.00

Exalpha L115P Sheep anti Avian TGF beta II receptor (77-148) 100 µg 4179.00

Exalpha L110P Sheep anti Chicken TGF beta II receptor (27-85) 50 µg 4179.00

Exalpha L105P Rabbit anti Human, Mouse Interferon (includes alpha 1 and 2a) 100 µg 4179.00

Exalpha K140P Sheep anti Mouse p38 HOG Kinase 250 µg 4179.00

Exalpha K135P Sheep anti Mouse SAP kinase 250 µg 4179.00

Exalpha K130P Sheep anti Mouse ERK1 + ERK2 250 µg 4179.00

Exalpha K115P Sheep anti Human Guanalyate Kinase GKWW domain (MAGI) 250 µg 4179.00

Exalpha K110P Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI) 250 µg 4179.00

CH 275

发表于2024年2月14日由Whatman官网

CH 275;

CH 275 是一种生长抑素的肽类似物，可以与生长抑素受体1 (sst₁) 结合 (K_i=52 nM)。CH 275 是一种有效的选择性 sst₁ 激动剂 (IC₅₀=30.9 nM)，刺激 sst₃，sst₄，sst₂ 和 sst₅ 的 IC₅₀ 值分别为 345 nM，>1 μM，>10 μM 和 >10 μM。CH 275 可用于阿尔茨海默病的研究。

CH 275 Chemical Structure

CAS No. : 174688-78-9

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM^[1]. CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively^[2]. CH 275 can be used for the research of alzheimer’s disease^[3].
IC₅₀ Target	IC50: 30.9 nM; Ki: 52 nM (somatostatin receptor 1)^[1]^[2] IC50: 345 nM (somatostatin receptor 3)^[1]
体外研究 (In Vitro)	CH275 (100 nM) activates neprilysin activity, wheras treatment with cyclo-SRIF can complete this activation in vitro in primary neuron-based cell culture system, a mixture of wildtype hippocampal, cortical and striatal neuron^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	CH275 (osmotic pump administration; 56 μM; two weeks) decreases the level of neprilysin/SRIF in the App knock-in mice^[3]. CH275 directly injects into the Lacunosum molecular layer (Lmol) layer of 2-month-old App^NL-G-F mice for four months. App^NL-G-F mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1485.77
Formula	C₇₄H₉₆N₁₄O₁₅S₂
CAS 号	174688-78-9
Sequence Shortening	CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. L Chen, et al. Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem Biophys Res Commun. 1999 May 19;258(3):689-94. [2]. J E Rivier, et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J Med Chem. 2001 Jun 21;44(13):2238-46. [3]. Per Nilsson, et al. Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid β-degrading enzyme, in brain.

Cytiva思拓凡-Whatman滤纸滤膜滤器

沃特曼官网代理商|Whatman滤纸滤膜中国官网代理商

标签归档：nm

荧光染料Indo-1 AM(Synonyms: Indo-1 Acetoxymethyl ester)

荧光染料ADHP(Synonyms: 10-Acetyl-3,7-dihydroxyphenoxazine)

Cy7.5

Research Diets动物饲料98121701NM Formula 模型饲料配方表

98121701NM

RD Low Fat Diet Without Cholesterol

纯化饲料配方表

饲料营养素热量组成 Physiological Fuel Values

DiBAC4(3)

DiBAC4(3) 相关产品

bull;相关化合物库:

DDAO

DDAO 相关产品

bull;相关化合物库:

FD-1080

Nordic-MUbio N125M Mouse anti Human Rb (Retinoblastoma) 100 µg

Exalpha N135M Mouse anti Human Rb (Retinoblastoma) 100 µg

CH 275

2024年 4月
一	二	三	四	五	六	日
1	2	3	4	5	6	7
8	9	10	11	12	13	14
15	16	17	18	19	20	21
22	23	24	25	26	27	28
29	30