Polymyxin B nonapeptide;(Synonyms: 多粘菌素B九肽)
Polymyxin B nonapeptide 是一种阳离子环肽。Polymyxin B nonapeptide 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。
Polymyxin B nonapeptide Chemical Structure
CAS No. : 86408-36-8
规格 | 价格 | 是否有货 | |
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10;mM;*;1 mL in DMSO | ¥2650 | 询问价格 货期 | |
5 mg | ¥1500 | 询问价格 货期 | |
10 mg | ¥2500 | 询问价格 货期 | |
50 mg | ¥9500 | 询问价格 货期 | |
100 mg | ¥16500 | 询问价格 货期 |
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Polymyxin B nonapeptide 的其他形式现货产品:
生物活性 |
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2]. |
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体外研究 (In Vitro) |
Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
963.13 |
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Formula |
C43H74N14O11 |
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CAS 号 |
86408-36-8 |
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Sequence |
Thr-{Dab}-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9) |
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Sequence Shortening |
T-{Dab}-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9) |
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中文名称 |
多粘菌素B九肽 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Protect from light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:;
H2O : ≥ 100 mg/mL (103.83 mM) DMSO : 16.67 mg/mL (17.31 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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