AUNP-12;(Synonyms: NP-12)
AUNP-12 (NP-12) 是 PD-1 信号通路的一种多肽拮抗剂,在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。AUNP-12 具有免疫激活作用、良好的抗肿瘤活性,具有更好的研究免疫相关不良事件 (irAEs) 的潜力。
AUNP-12 Chemical Structure
CAS No. : 1353563-85-5
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是否有货 |
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100 mg |
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250 mg |
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500 mg |
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* Please select Quantity before adding items.
AUNP-12 的其他形式现货产品:
AUNP-12 TFA
生物活性 |
AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].
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IC50 Target |
PD-1 signaling pathway[1]
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体外研究 (In Vitro) |
AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1]. AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1]. AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Formula |
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Sequence Shortening |
H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献 |
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