[Nphe1]Nociceptin(1-13)NH2 TFA

[Nphe1]Nociceptin(1-13)NH2 TFA;

[Nphe1]Nociceptin(1-13) NH2 TFA 是一种 Nociceptin/orphanin FQ (NC) 内源性配体,是一种选择性和竞争性的 ociceptin receptor 拮抗剂,不具有激动剂活性。[Nphe1]nociceptin(1-13)NH2 选择性结合重组 nociceptin 受体(pKi=8.4),拮抗 nociceptin 对 CHO 细胞中 cAMP 积累的抑制作用(pA2=6.0)。[Nphe1]Nociceptin(1-13)NH2 有可能作为一种止痛试剂。

[Nphe1]Nociceptin(1-13)NH2 TFAamp;;

[Nphe1]Nociceptin(1-13)NH2 TFA Chemical Structure

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生物活性

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].

体外研究
(In Vitro)

[Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0) .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1495.61

Formula

C63H101F3N22O17

Sequence Shortening

Bn-GGGFTGARKSARK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor

    [2]. G Calo’, et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol. 2000 Mar;129(6):1183-93.

[Nphe1]Nociceptin(1-13)NH2

[Nphe1]Nociceptin(1-13)NH2;

[Nphe1]Nociceptin(1-13) NH2 是一种 Nociceptin/orphanin FQ (NC) 内源性配体,是一种选择性和竞争性的 ociceptin receptor 拮抗剂,不具有激动剂活性。[Nphe1]nociceptin(1-13)NH2 选择性结合重组 nociceptin 受体(pKi=8.4),拮抗 nociceptin 对 CHO 细胞中 cAMP 积累的抑制作用(pA2=6.0)。[Nphe1]Nociceptin(1-13)NH2 有可能作为一种止痛试剂。

[Nphe1]Nociceptin(1-13)NH2amp;;

[Nphe1]Nociceptin(1-13)NH2 Chemical Structure

CAS No. : 267234-08-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].

体外研究
(In Vitro)

[Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1381.59

Formula

C61H100N22O15

CAS 号

267234-08-2

Sequence Shortening

Bn-GGGFTGARKSARK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor

    [2]. G Calo’, et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol. 2000 Mar;129(6):1183-93.