标签归档：obestatin

Obestatin(rat)

发表于由

Obestatin(rat);

Obestatin(rat) 是一种由 Ghrelin 基因编码的肽，由 23 个氨基酸组成。Obestatin(rat) 抑制食物摄入，抑制空肠收缩，并减少体重增加。Obestatin(rat) 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体，具有抗炎，抗心肌梗塞和抗氧化的作用。

Obestatin(rat)amp;;

Obestatin(rat) Chemical Structure

CAS No. : 869705-22-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities[1][2].

分子量

2516.81

Formula

C114H174N34O31
CAS 号

869705-22-6
Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
Sequence Shortening

FNAPFDVGIKLSGAQYQQHGRAL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Azadeh Toosi, et al. Obestatin Improve Spatial Memory Impairment in a Rat Model of Fetal Alcohol Spectrum Disorders via Inhibiting Apoptosis and Neuroinflammation. Neuropeptides. 2019 Apr;74:88-94.

    [2]. Science. 2005 Nov 11;310(5750):996-9. doi: 10.1126/science.1117255.

Obestatin(human) TFA

发表于由

Obestatin(human) TFA;

Obestatin(human) TFA is an endogenous peptide derived from the same prepropeptide as ghrelin. Obestatin(human) suppresses food intake and reduce body weight-gain in rats.

Obestatin(human) TFAamp;;

Obestatin(human) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Obestatin(human) TFA is an endogenous peptide derived from the same prepropeptide as ghrelin. Obestatin(human) suppresses food intake and reduce body weight-gain in rats.

分子量

2660.88

Formula

C118H177F3N32O35
Sequence Shortening

FNAPFDVGIKLSGVQYQQHSQAL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Obestatin(human)

发表于由

Obestatin(human);

Obestatin(human) 是一种 23 个氨基酸的酰胺化肽，通过与 GPR39 的相互作用调节食欲和胃肠蠕动。Obestatin(human) 可用于减肥。Obestatin(human) 不能穿透细胞膜。

Obestatin(human)amp;;

Obestatin(human) Chemical Structure

CAS No. : 1081110-72-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss. Obestatin(human) cannot penetrate the cell membrane[1][2].

体外研究
(In Vitro)

The primary structure of Obestatin(human) indicates that it only presented one lysine at position 10, which suggests that it cannot penetrate the cell membrane[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In adult male mice, intraperitoneal injection of Obestatin(human) suppresses food intake in a timeand dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2546.86

Formula

C116H176N32O33
CAS 号

1081110-72-6
Sequence Shortening

FNAPFDVGIKLSGVQYQQHSQAL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Guangcai Ren, et al. Effect of TAT-obestatin on proliferation, differentiation, apoptosis and lipolysis in 3T3-L1 preadipocytes. J Pept Sci. 2013 Nov;19(11):684-91.

    [2]. Jian V Zhang, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science. 2005 Nov 11;310(5750):996-9.

Obestatin (Rat,Mouse) 品牌：Peptide

发表于由

Obestatin (Rat,Mouse)

品牌：Peptide
CAS No.：869705-22-6
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

333-44301

 – 0.1mg – 咨询 – –


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Obestatin(rat) TFA

发表于由

Obestatin(rat) TFA;

Obestatin(rat) TFA 是一种由 Ghrelin 基因编码的肽，由 23 个氨基酸组成。Obestatin(rat) TFA 抑制食物摄入，抑制空肠收缩，并减少体重增加。Obestatin(rat) TFA 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体，具有抗炎，抗心肌梗塞和抗氧化的作用。

Obestatin(rat) TFAamp;;

Obestatin(rat) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities[1][2].

分子量

2630.83

Formula

C116H175F3N34O33
Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
Sequence Shortening

FNAPFDVGIKLSGAQYQQHGRAL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Azadeh Toosi, et al. Obestatin Improve Spatial Memory Impairment in a Rat Model of Fetal Alcohol Spectrum Disorders via Inhibiting Apoptosis and Neuroinflammation. Neuropeptides. 2019 Apr;74:88-94.

    [2]. Science. 2005 Nov 11;310(5750):996-9. doi: 10.1126/science.1117255.