天然产物醌类Quinones
Obtusifolin (Synonyms: 决明蒽醌)
Obtusifolin 是从决明子的种子中分离出,通过抑制 NF-kB 通路来调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。Obtusifolin 通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
Obtusifolin Chemical Structure
CAS No. : 477-85-0
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3030 | In-stock | |
10 mg | ¥5140 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Obtusifolin 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
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- NF-κB Signaling Compound Library
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生物活性 |
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
284.26 |
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Formula |
C16H12O5 |
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CAS 号 |
477-85-0 |
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中文名称 |
决明蒽醌 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 10 mg/mL (35.18 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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