H-Ile-Pro-Pro-OH hydrochloride

H-Ile-Pro-Pro-OH hydrochloride; 纯度: 98.19%

H-Ile-Pro-Pro-OH hydrochloride 是一种乳源三肽,抑制血管紧张素转换酶 (ACE) ,IC50 为 5 μM。具有抗高血压效果。

H-Ile-Pro-Pro-OH hydrochlorideamp;;

H-Ile-Pro-Pro-OH hydrochloride Chemical Structure

CAS No. : 1208862-61-6

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ¥880 In-stock
50 mg ¥800 In-stock
100 mg ¥1100 In-stock
250 mg ¥2100 询价
500 mg ; 询价 ;
1 g ; 询价 ;

* Please select Quantity before adding items.

H-Ile-Pro-Pro-OH hydrochloride 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • Angiogenesis Related Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

IC50 Target

IC50: 5 μM (ACE)[2]

体外研究
(In Vitro)

Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

361.86

Formula

C16H28ClN3O4

CAS 号

1208862-61-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

H2O : 55 mg/mL (151.99 mM; Need ultrasonic)

DMSO : 36.67 mg/mL (101.34 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7635 mL 13.8175 mL 27.6350 mL
5 mM 0.5527 mL 2.7635 mL 5.5270 mL
10 mM 0.2763 mL 1.3817 mL 2.7635 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.75 mg/mL (7.60 mM); Clear solution

    此方案可获得 ≥ 2.75 mg/mL (7.60 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (7.60 mM); Clear solution

    此方案可获得 ≥ 2.75 mg/mL (7.60 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.75 mg/mL (7.60 mM); Clear solution

    此方案可获得 ≥ 2.75 mg/mL (7.60 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7.

    [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

H-Gly-Pro-OH

H-Gly-Pro-OH; 纯度: ge;97.0%

H-Gly-Pro-OH 是胶原蛋白代谢的最终产物,它会进一步被脯氨肽酶进一步裂解。

H-Gly-Pro-OHamp;;

H-Gly-Pro-OH Chemical Structure

CAS No. : 704-15-4

规格 价格 是否有货 数量
100 mg ¥500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

H-Gly-Pro-OH 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • Peptidomimetic Library
  • Food-Sourced Compound Library
  • Peptide Library

生物活性

H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

IC50 Target

Human Endogenous Metabolite

;

分子量

172.18

Formula

C7H12N2O3

CAS 号

704-15-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 1 mg/mL (5.81 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.8079 mL 29.0394 mL 58.0788 mL
5 mM 1.1616 mL 5.8079 mL 11.6158 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Le J, et al. Urine glycyl-L-proline increase and skin trophicity. Amino Acids. 1999;17(3):315-22.

Z-Glu-Tyr-OH

Z-Glu-Tyr-OH; 纯度: 99.88%

Z-Glu-Tyr-OH 可用于固相肽的合成。

Z-Glu-Tyr-OHamp;;

Z-Glu-Tyr-OH Chemical Structure

CAS No. : 988-75-0

规格 价格 是否有货 数量
25 mg ¥600 In-stock
50 mg ¥1000 In-stock
100 mg ¥1600 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Z-Glu-Tyr-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Z-Glu-Tyr-OH can be used for synthesis of peptides on a solid support[1].

分子量

444.43

Formula

C22H24N2O8

CAS 号

988-75-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (225.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2501 mL 11.2504 mL 22.5007 mL
5 mM 0.4500 mL 2.2501 mL 4.5001 mL
10 mM 0.2250 mL 1.1250 mL 2.2501 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (5.63 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.63 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.63 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.63 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.63 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.63 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Rose Haddoub, et al. Enzymatic Synthesis of Peptides on a Solid Support. Org Biomol Chem

Ala-Glu-OH

Ala-Glu-OH; 纯度: ge;98.0%

Ala-Glu-OH 是一种二肽试剂。

Ala-Glu-OHamp;;

Ala-Glu-OH Chemical Structure

CAS No. : 13187-90-1

规格 价格 是否有货 数量
10 mg ¥500 In-stock
25 mg ¥900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Ala-Glu-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Ala-Glu-OH is an agent of the dipeptide[1][2].

分子量

218.21

Formula

C8H14N2O5

CAS 号

13187-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 250 mg/mL (1145.69 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5827 mL 22.9137 mL 45.8274 mL
5 mM 0.9165 mL 4.5827 mL 9.1655 mL
10 mM 0.4583 mL 2.2914 mL 4.5827 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Smid EJ, et al. Mechanism and energetics of dipeptide transport in membrane vesicles of Lactococcus lactis. J Bacteriol. 1989;171(1):292-298.

    [2]. Kim SJ, et al. Replacement of glutamine with the dipeptide derivative alanyl-glutamine enhances in vitro maturation of porcine oocytes and development of embryos. Zygote. 2014;22(2):286-289.

H-Ala-Ala-Tyr-OH TFA

H-Ala-Ala-Tyr-OH TFA;

H-Ala-Ala-Tyr-OH TFA 可用于合成突变型多肽。

H-Ala-Ala-Tyr-OH TFAamp;;

H-Ala-Ala-Tyr-OH TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

H-Ala-Ala-Tyr-OH TFA can be synthesized mutant peptides[1][2].

分子量

437.37

Formula

C17H22F3N3O7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. das Neves GM, et al. In Silico Design of New Inhibitors of Guanine Phosphoribosyltransferase (GPRT) from Giardia lamblia as Antiparasitic Drug Candidates. Curr Drug Discov Technol. 2017;14(1):8-24.

    [2]. B-cell antigenic multi-epitope peptide linked in tandem in OmpU of vibrio mimicus, making method and application thereof. CN101747416A.

H-Ala-Ala-Tyr-OH

H-Ala-Ala-Tyr-OH;

H-Ala-Ala-Tyr-OH 用于合成突变型多肽。

H-Ala-Ala-Tyr-OHamp;;

H-Ala-Ala-Tyr-OH Chemical Structure

CAS No. : 67131-52-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

H-Ala-Ala-Tyr-OH can be synthesized mutant peptides[1][2].

分子量

323.34

Formula

C15H21N3O5

CAS 号

67131-52-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. das Neves GM, et al. In Silico Design of New Inhibitors of Guanine Phosphoribosyltransferase (GPRT) from Giardia lamblia as Antiparasitic Drug Candidates. Curr Drug Discov Technol. 2017;14(1):8-24.

    [2]. B-cell antigenic multi-epitope peptide linked in tandem in OmpU of vibrio mimicus, making method and application thereof. CN101747416A.

H-Glu(Met-OH)-OH

H-Glu(Met-OH)-OH;

H-Glu(Met-OH)-OH 可引起羟基自由基的氧化。

H-Glu(Met-OH)-OHamp;;

H-Glu(Met-OH)-OH Chemical Structure

CAS No. : 17663-87-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

H-Glu(Met-OH)-OH could induce oxidation of hydroxyl radical[1].

分子量

278.33

Formula

C10H18N2O5S

CAS 号

17663-87-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Krzysztof Bobrowski, et al.˙OH radical induced decarboxylation of γ-glutamylmethionine and S-alkylglutathione derivatives: evidence for two different pathways involving C- and N-terminal decarboxylation. Journal of the Chemical Society, Perkin Transactions 2.

H-Ile-Pro-Pro-OH

H-Ile-Pro-Pro-OH;

H-Ile-Pro-Pro-OH 是一种乳源三肽,抑制血管紧张素转换酶 (ACE) ,IC50 为 5 μM。具有抗高血压效果。

H-Ile-Pro-Pro-OHamp;;

H-Ile-Pro-Pro-OH Chemical Structure

CAS No. : 26001-32-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

H-Ile-Pro-Pro-OH 的其他形式现货产品:

H-Ile-Pro-Pro-OH hydrochloride

生物活性

H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

IC50 Target

IC50: 5 μM (ACE)[2]

体外研究
(In Vitro)

Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

325.40

Formula

C16H27N3O4

CAS 号

26001-32-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7.

    [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

H-Val-Pro-Pro-OH

H-Val-Pro-Pro-OH;

H-Val-Pro-Pro-OH,是牛奶来源的脯氨酸肽衍生物,是血管紧张素 I 转化酶 (ACE) 的抑制剂,其IC50 为 9 μM。

H-Val-Pro-Pro-OHamp;;

H-Val-Pro-Pro-OH Chemical Structure

CAS No. : 58872-39-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

H-Val-Pro-Pro-OH 的其他形式现货产品:

H-Val-Pro-Pro-OH TFA

生物活性

H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.

IC50 Target

IC50: 9 μM (ACE)[1].

体外研究
(In Vitro)

H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM[1]. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

311.38

Formula

C15H25N3O4

CAS 号

58872-39-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

    [2]. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187.