[D-Asn5]-Oxytocin possesses very low specific oxytocic and vasodepressor activities. By cumulative dose-response studies for oxytocic activity, [D-Asn5]-Oxytocin has similar intrinsic activity to oxytocin[1].
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Dutta AS, et al. Synthesis and pharmacological activity of 4-d-glutamine-oxytocin, 5-d-asparagine-oxytocin, and 4-d-glutamine-5-d-asparagine-oxytocin. J Med Chem. 1966;9(4):497-499.
Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer[1].
体外研究 (In Vitro)
The parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin show biological activities ranged from 0.2% to 6% that of oxytocin[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
2014.37
Formula
C86H132N24O24S4
CAS 号
19645-28-4
Sequence Shortening
Sequence 1:CYIQNCPLG-NH2;Sequence 2:CYIQNCPLG-NH2 (Disulfide bridge:Chain1 Cys1 to Chain2 Cys1;Chain1 Cys6 to Chain2 Cys6)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Chen L, et al. Syntheses and biological activities of parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin. Pept Res. 1996;9(3):114-121.
Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior[1][2].
分子量
1008.17
Formula
C43H65N11O13S2
CAS 号
4248-64-0
Sequence Shortening
CYIQNCPLG (Disulfide bridge:Cys1-Cys6)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Ferrier BM, et al. 9-Deamidooxytocin, an analog of the hormone containing a glycine residue in place of the glycinamide residue. J Med Chem. 1966;9(1):55-57.
[2]. Carter CS, Kenkel WM, MacLean EL, et al. Is Oxytocin “Nature’s Medicine”?. Pharmacol Rev. 2020;72(4):829-861.
Oxytocin antiparallel dimer is the disulfide-bridged homo peptide dimer[1].
体外研究 (In Vitro)
The parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin show biological activities ranged from 0.2% to 6% that of oxytocin[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
2014.37
Formula
C86H132N24O24S4
CAS 号
20054-93-7
Sequence Shortening
Sequence 1:CYIQNCPLG-NH2;Sequence 2:CYIQNCPLG-NH2 (Disulfide bridge:Chain1 Cys1 to Chain2 Cys6;Chain1 Cys6 to Chain2 Cys1)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Chen L, et al. Syntheses and biological activities of parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin. Pept Res. 1996;9(3):114-121.
[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity[1].
体外研究 (In Vitro)
[Asp5]-Oxytocin retains not only a high affinity for the uterotonic receptor, but, more importantly, it exhibits an intrinsic activity identical with that of oxytocin under various experimental conditions[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1008.17
Formula
C43H65N11O13S2
CAS 号
65907-78-0
Sequence Shortening
CYIQDCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Walter R, et al. [5-Aspartic acid]-oxytocin: first 5-position neurohypophyseal hormone analogue possessing significant biological activity. J Am Chem Soc. 1978;100(3):792-793.
[Leu3]-Oxytocin, an oxytocin analogue, is derived by structural variation in sequence position 3 replaced by leucine (Leu)[1].
分子量
1007.19
Formula
C43H66N12O12S2
CAS 号
4294-11-5
Sequence Shortening
CYLQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Krejcí I, et al. Effect of magnesium on the action of oxytocin and a group of analogues on the uterus in vitro. Eur J Pharmacol. 1968;2(5):393-398.
[Glu4]-Oxytocin is an appropriate derivative of oxytocin for conducting a comprehensive investigation by a variety of methods of the conformation of “oxytocin-like” molecules in aqueous solution[1].
分子量
1008.17
Formula
C43H65N11O13S2
CAS 号
4314-67-4
Sequence Shortening
CYIENCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Walter R, et al. H N.M.R. study of the conformation of [Glu4] oxytocin and its lanthanide complexes in aqueous solution. Int J Pept Protein Res. 1981;17(1):56-64.
Oxytocin acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].
IC50 Target
Human Endogenous Metabolite
;
体内研究 (In Vivo)
During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Fifty-six male Lister-hooded rats (150–200 g)[1]
Dosage:
0.1 mg/kg-0.3 mg/kg
Administration:
Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result:
Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
[1]. Shivali Kohli, et al. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats. Neuropsychopharmacology. 2019 Jan;44(2):295-305.
[2]. C Sue Carter, et al. Is Oxytocin “Nature’s Medicine”? Pharmacol Rev. 2020 Oct;72(4):829-861.
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].
IC50 Target
Human Endogenous Metabolite
;
体内研究 (In Vivo)
During the LMA task, rat core body temperature are modestly decreased. Oxytocin (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].Oxytocin (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Fifty-six male Lister-hooded rats (150-200 g)[1]
Dosage:
0.1 mg/kg-0.3 mg/kg
Administration:
Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result:
Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
[1]. Shivali Kohli, et al. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats. Neuropsychopharmacology. 2019 Jan;44(2):295-305.
[2]. C Sue Carter, et al. Is Oxytocin “Nature’s Medicine”? Pharmacol Rev. 2020 Oct;72(4):829-861.
![[D-Asn5]-Oxytocinamp;;](http://file.medchemexpress.cn/product_pic/hy-p3220.gif "[D-Asn5]-Oxytocin Chemical Structure")
![[Asp5]-Oxytocinamp;;](http://file.medchemexpress.cn/product_pic/hy-p3217.gif "[Asp5]-Oxytocin Chemical Structure")
![[Leu3]-Oxytocinamp;;](http://file.medchemexpress.cn/product_pic/hy-p3221.gif "[Leu3]-Oxytocin Chemical Structure")
![[Glu4]-Oxytocinamp;;](http://file.medchemexpress.cn/product_pic/hy-p3218.gif "[Glu4]-Oxytocin Chemical Structure")
