iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers drugs deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity[1].
体外研究 (In Vitro)
iRGD peptide 1 (iRGD) inhibits migration of tumor cells and caused chemorepulsion in vitro in a CendR- and NRP-1-dependent manner. iRGD peptide 1 induces dramatic collapse of cellular processes and partial cell detachment, resulting in the repellent activity. These effects are prominently displayed when the cells are seeded on fibronectin, suggesting a role of CendR in functional regulation of integrins[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
iRGD peptide 1 (amino acid sequence: CRGDKGPDC; 4 μmol/kg; intravenous injection; every other day; for 21 days) potently inhibits spontaneous metastasis in mice[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1064.08
Formula
C37H60F3N13O16S2
Sequence
Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys
Sequence Shortening
CRGDKGPDC
运输条件
Room temperature in continental US; may vary elsewhere.
Small Cardioactive Peptide B (SCPB) 是一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC50 分别为 0.1 和 1.0 μM。
Small Cardioactive Peptide B (SCPB) Chemical Structure
CAS No. : 84746-43-0
规格
价格
是否有货
数量
1 mg
￥700
In-stock
5 mg
￥2100
In-stock
10 mg
￥3300
In-stock
50 mg
;
询价
;
100 mg
;
询价
;
* Please select Quantity before adding items.
Small Cardioactive Peptide B (SCPB) 相关产品
bull;相关化合物库:
Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Reprogramming Compound Library
Anti-Cardiovascular Disease Compound Library
Peptide Library
生物活性
Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
IC50 Target
EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)[1]
体外研究 (In Vitro)
Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM, respectively[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1141.41
Formula
C52H80N14O11S2
CAS 号
84746-43-0
Sequence
Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2
Sequence Shortening
MNYLAFPRM-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Protect from light, stored under nitrogen
Powder
-80deg;C
2 years
-20deg;C
1 year
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;
H2O : 50 mg/mL (43.81 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
0.8761 mL
4.3805 mL
8.7611 mL
5 mM
0.1752 mL
0.8761 mL
1.7522 mL
10 mM
0.0876 mL
0.4381 mL
0.8761 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献
[1]. Cawthorpe DR, et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24.
