标签归档：plv

Felypressin acetate(Synonyms: PLV-2 acetate)

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Felypressin acetate;(Synonyms: PLV-2 acetate)

Felypressin acetate (PLV-2 acetate) 是一种非儿茶酚胺的血管收缩剂，也是一种加压素 1 (vasopressin 1) 激动剂。Felypressin acetate 广泛用于牙科手术中。

Felypressin acetateamp;;(Synonyms: PLV-2 acetate)

Felypressin acetate Chemical Structure

CAS No. : 914453-97-7

规格 是否有货
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Felypressin acetate 的其他形式现货产品:

Felypressin

生物活性

Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures[1][2].

IC50 Target

Vasopressin 1[2]
体外研究
(In Vitro)

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure[1].
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

Formula

C46H65N13O11S2.xC2H4O2
CAS 号

914453-97-7
Sequence

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
Sequence Shortening

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)
中文名称

醋酸苯赖加压素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bronzo AL et al. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31.

    [2]. Cecanho R et al. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.