ATP-polyamine-biotin(Synonyms: ATP多胺生物素)

生化分析试剂 Biochemical Assay Reagents
ATP-polyamine-biotin;(Synonyms: ATP多胺生物素) 纯度: 99.95%

ATP-polyamine-biotin,是第一种可透过细胞的 ATP 类似物,是一种有效的激酶共底物。ATP-polyamine-biotin 可促进活细胞中激酶底物的生物素标记。

ATP-polyamine-biotin(Synonyms: ATP多胺生物素)

ATP-polyamine-biotin Chemical Structure

CAS No. : 1800401-93-7

规格 价格 是否有货 数量
1 mg ¥4500 In-stock
2 mg ¥8000 In-stock
5 mg ¥14000 In-stock
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ATP-polyamine-biotin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells[1].

体外研究
(In Vitro)

ATP-polyamine-biotin (APB) is incubated with PKA kinase and full-length protein substrate, myelin basic protein (MBP). Biotinylation was observed only in presence of kinase. In addition, MBP biotinylation was lost in the absence of ATP-polyamine-biotin, in presence of the kinase inhibitor staursporine or upon incubation with acid due to cleavage of phosphoramidate bond. Biotinylated kemptide product is observed only in the presence of APB cosubstrate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

945.85

Formula

C32H58N11O14P3S

CAS 号

1800401-93-7

中文名称

ATP多胺生物素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

H2O : 6 mg/mL (6.34 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0573 mL 5.2863 mL 10.5725 mL
5 mM 0.2115 mL 1.0573 mL 2.1145 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Fouda AE, et al. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9618-21.