PEG300(Synonyms: 聚乙二醇; Polyethylene glycol 300)

生化分析试剂 Biochemical Assay Reagents
PEG300;(Synonyms: 聚乙二醇; Polyethylene glycol 300)

PEG300 (Polyethylene glycol 300),分子量为300的中性聚合物,由乙二醇重复单元形成的水溶性、低免疫原性和生物相容性聚合物。

PEG300(Synonyms: 聚乙二醇; Polyethylene glycol 300)

PEG300 Chemical Structure

CAS No. : 25322-68-3

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50 mL ¥350 In-stock
100 mL ¥450 In-stock
200 mL ¥765 In-stock
500 mL ; 询价 ;
1L ; 询价 ;

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生物活性

PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol[1][2].

体外研究
(In Vitro)

The FDA has approved polyethylene glycol (PEG) for use as a vehicle or base in foods, cosmetics and pharmaceuticals, including injectable, topical, rectal and nasal formulations. PEG shows little toxicity, and is eliminated from the body intact by either the kidneys (for PEGs < 30 kDa) or in the faeces (for PEGs > 20 kDa). PEG lacks immunogenicity, and antibodies to PEG are generated in rabbits only if PEG is combined with highly immunogenic proteins[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

300.00

CAS 号

25322-68-3

中文名称

聚乙二醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (333.33 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (166.67 mM)

* “≥” means soluble, but saturation unknown.

参考文献
  • [1]. J.Billingham, et al. Adsorption of polyamine, polyacrylic acid and polyethylene glycol on montmorillonite: An in situ study using ATR-FTIR. Volume 14, Issue 1, March 1997, Pages 19-34.

    [2]. Lee CC, et al. Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci. 2020 Jan 7;27(1):12.

    [3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21.

    [4]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.

    [5]. Ellen Weisberg, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.

Polyethylene glycol 12-hydroxystearate

生化分析试剂 Biochemical Assay Reagents
Polyethylene glycol 12-hydroxystearate;

Polyethylene glycol 12-hydroxystearate, 一种 Macrogol 15 羟基硬脂酸酯,是一种通透性增强剂。

Polyethylene glycol 12-hydroxystearate

Polyethylene glycol 12-hydroxystearate Chemical Structure

CAS No. : 61909-81-7

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10 g ¥500 In-stock
50 g ¥800 In-stock
> 100 g ; 询价 ;

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生物活性

Polyethylene glycol 12-hydroxystearate, a Macrogol 15 hydroxy stearate, is a permeability enhancer[1].

体外研究
(In Vitro)

Polyethylene glycol 12-hydroxystearate is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Polyethylene glycol 12-hydroxystearate has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C20H40O4

CAS 号

61909-81-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

溶解性数据
In Vitro:;

Ethanol : 100 mg/mL (Need ultrasonic)

参考文献
  • [1]. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb (Solutol HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.

Cell Assay
[1]

For both MTS and LDH cell viability assays, cells are seeded at a density of 1×104 cells on 96-well plates and cultured for a minimum of 24 h. Solutol HS-15 (in 25 mM HBSS:HEPES, pH 7.4) solutions are applied at concentrations above and below the critical micelle concentration (CMC) (0.01 mM to 20 mM) and cytotoxicity is determined using the MTS and LDH assays. 25 mM HBSS:HEPES is used as a negative control and Triton-X 100 (3 mM) as a positive control. Following 3 h incubation, the MTS reagent in media and LDH working solution are added to the cells and the cells are incubated for a further 3 h at 37°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb (Solutol HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.

Polyethylene Glycol Mono-4-octylphenyl Ether

生化分析试剂 Biochemical Assay Reagents
Polyethylene Glycol Mono-4-octylphenyl Ether;

Polyethylene Glycol Mono-4-octylphenyl Ether 是一种低聚混合物,可用于生化研究。

Polyethylene Glycol Mono-4-octylphenyl Ether

Polyethylene Glycol Mono-4-octylphenyl Ether Chemical Structure

CAS No. : 9002-93-1

规格 价格 是否有货 数量
5 mL ¥350 In-stock
10 mL ¥490 In-stock
50 mL ¥1050 In-stock

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Polyethylene Glycol Mono-4-octylphenyl Ether 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Polyethylene Glycol Mono-4-octylphenyl Ether is an oligomeric blend that can be used for biochemical research[1].

Formula

C16H26O2

CAS 号

9002-93-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Chien-FongLu, et al. The Journal of Chemical Thermodynamics. 2019 Aug.135:215-224.

Polyethylene glycol monoisotridecyl ether

生化分析试剂 Biochemical Assay Reagents
Polyethylene glycol monoisotridecyl ether;

Polyethylene glycol monoisotridecyl ether 是一种表面活性剂。

Polyethylene glycol monoisotridecyl ether

Polyethylene glycol monoisotridecyl ether Chemical Structure

CAS No. : 9043-30-5

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100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Polyethylene glycol monoisotridecyl ether is a surfactant[1].

Formula

(C2H4O)nC13H28O

CAS 号

9043-30-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Bruce J. et al. Sorption of Nonionic Surfactants on Sediment Materials. Environmental Science Technology 1997 31 (6), 1735-1741.