Polyphyllin VI,一种活性皂甙,具有抗癌活性。Polyphyllin VI 诱导 G2/M 细胞周期停滞并引发细胞凋亡。Polyphyllin VI 通过诱导非小细胞肺癌中的 ROS/NF-κB/NLRP3/GSDMD 信号轴来诱导 caspase-1 介导的细胞焦亡 (pyroptosis)。
Polyphyllin VI Chemical Structure
CAS No. : 55916-51-3
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生物活性
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis[1][2]. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer[3].
分子量
738.90
Formula
C39H62O13
CAS 号
55916-51-3
中文名称
重楼皂苷VI
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Lin Z, et al. Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo. Phytother Res. 2015 Oct;29(10):1568-76.
[2]. Liu Y, et al. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel). 2018 May 15;10(5). pii: E201.
[3]. Jin-Feng Teng, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Jan 13;12(1):193.
Polyphyllin G 重楼皂苷G 是从 Paris yunnanensis 的根茎中分离出来的,具有抗菌和抗癌活性。 Polyphyllin G 以最小的抑制浓度 (MIC) 阻止革兰氏阳性和革兰氏阴性细菌的生长。Polyphyllin G 诱导凋亡 (apoptosis) 依赖于 caspase-8,-3 和 -9 的激活,诱导自噬 (autophagy)。
Polyphyllin G Chemical Structure
CAS No. : 76296-75-8
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价格
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1 mg
¥1000
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¥2500
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生物活性
Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs)[1]. Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy[2].
分子量
1049.20
Formula
C51H84O22
CAS 号
76296-75-8
中文名称
重楼皂苷G
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Cai X, et al. Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2. Arch Biochem Biophys. 2018 Apr 15;644:93-99.
[2]. Hsieh MJ, et al. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016 Dec 1;23(13):1545-1554.
上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Polyphyllin II(Synonyms: 重楼皂苷 II)
Polyphyllin II 是重楼中最重要的皂苷之一,对多种癌细胞有毒害作用。Polyphyllin II 通过 caspases 激活和细胞周期停滞诱导细胞凋亡。
Polyphyllin II Chemical Structure
CAS No. : 76296-72-5
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¥800
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生物活性
Polyphyllin II is one of the most significant saponins in Rhizoma Paridis and has toxic effects on kinds of cancer cells. Polyphyllin II induces apoptosis through caspases activation and cell-cycle arrest[1].
分子量
855.02
Formula
C44H70O16
CAS 号
76296-72-5
中文名称
重楼皂苷 II
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro:
DMSO : 100 mg/mL (116.96 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
1.1696 mL
5.8478 mL
11.6956 mL
5 mM
0.2339 mL
1.1696 mL
2.3391 mL
10 mM
0.1170 mL
0.5848 mL
1.1696 mL
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
[1]. Wang W, et al. Apoptosis in HepaRG and HL-7702 cells inducted by polyphyllin II through caspases activation and cell-cycle arrest. J Cell Physiol. 2019 May;234(5):7078-7089.
Polyphyllin H has been widely used in traditional Chinese medicinal preparations to treat inflammation, fracture and convulsion[1].
分子量
871.02
Formula
C44H70O17
CAS 号
81917-50-2
中文名称
重楼皂苷 H
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xingbin Yin, et al. Analysis and Pharmacokinetic Study of Polyphyllin H in Beagle Dog Plasma After Oral Administration of Rhizoma Paridis Extracts by LC-MS/MS. Biomed Chromatogr. 2014 Dec;28(12):1869-73.
Polyphyllin C (compound 2) 是一种甾烷型甾体皂苷。Polyphyllin C 表现出轻度的酪氨酸酶抑制活性 (IC50=36.87 µM) 和中度抗利什曼原虫 (IC50=1.59 µg/mL) 活性。
Polyphyllin C Chemical Structure
CAS No. : 76296-71-4
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25 mg
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生物活性
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities[1][2].
IC50 Target
IC50: 36.87 µM (tyrosinase)[1]
分子量
722.90
Formula
C39H62O12
CAS 号
76296-71-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Devkota KP, et, al. Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007 Apr;21(4):321-7.
[2]. Singh SB, et, al. Spirostanol saponins from Paris polyphylla, structures of polyphyllin C, D, E and F. Phytochemistry.1980; 21(12): 2925-2929.
Polyphyllin F is a diosgenyl saponin that can be found in Paris polyphylla[1][2].
分子量
1015.18
Formula
C51H82O20
CAS 号
76296-74-7
中文名称
重楼皂苷F
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Singh SB, et, al. Spirostanol saponins from Paris polyphylla, structures of polyphyllin C, D, E and F. Phytochemistry.1980; 21(12): 2925-2929.
[2]. Man S, et, al. Characterization of steroidal saponins in saponin extract from Paris polyphylla by liquid chromatography tandem multi-stage mass spectrometry. Anal Bioanal Chem. 2009 Sep;395(2):495-505.
Polyphyllin I 是一种从 Paris polyphylla 中提取的生物活性成分,具有很强的抗肿瘤活性。Polyphyllin I 是JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。Polyphyllin I 诱导自噬,G2/M 期阻滞和细胞凋亡。
Polyphyllin I Chemical Structure
CAS No. : 50773-41-6
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¥600
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生物活性
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].
IC50 Target
JNK signaling[2] PDK1/Akt/mTOR signaling[3]
分子量
855.02
Formula
C44H70O16
CAS 号
50773-41-6
中文名称
重楼皂苷I
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33.
[2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486.
[3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.