标签归档：rgd

CGGRGD

发表于由

CGGRGD;

CGGRGD，一种以半胱氨酸为 N 端 RGD 衍生物，CGGRGD 通过固相肽合成技术合成的，PCL 纤维的表面被氨基 2-氰基苯并噻唑氨解，然后加入 2-氰基苯并噻唑 (CBT)。

CGGRGDamp;;

CGGRGD Chemical Structure

CAS No. : 1260223-44-6

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

CGGRGD, a RGD derivative with cysteine as its N-terminal, CGGRGD is synthesized via solid-phase peptide synthesis technique and the surface of PCL fibers is aminolysised by amino 2-cyanobenzothiazole followed by the addition of 2-cyanobenzothiazole (CBT)[1].

体外研究
(In Vitro)

CGGRGD is a characteristic sequence of fifibronectin that binds to the receptors on cell surface (PCL) is a popular materials for tissue engineering due to its optimal biocompatibility, biodegradability, and thermoplastic characteristics[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

563.59

Formula

C19H33N9O9S
CAS 号

1260223-44-6
Sequence

Cys-Gly-Gly-Arg-Gly-Asp
Sequence Shortening

CGGRGD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wenting Zhen, et al.Functionalization of PCL fibrous membrane with RGD peptide

Echistatin

发表于由

Echistatin;

Echistatin 最初是来自蛇毒崩素家族中最小的 RGD 活性蛋白，是一种有效的血小板聚集的抑制剂。Echistatin 是体外骨吸收的有效抑制剂。Echistatin 是有效的 αIIbβ3、αvβ3 和α5β1 的拮抗剂。

Echistatinamp;;

Echistatin Chemical Structure

CAS No. : 154303-05-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4].

IC50 Target[4]

αvβ3

;

α5β1

;

αIIbβ3

;

分子量

5417.00

Formula

C217H341N71O74S9
CAS 号

154303-05-6
Sequence Shortening

ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT (Disulfide bridge:Cys2-Cys11;Cys7-Cys32;Cys8-Cys37;Cys20-Cys39)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.

    [2]. M Sato, et al. Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol. 1990 Oct;111(4):1713-23.

    [3]. C C Kumar, et al. Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):843-53.

    [4]. I Wierzbicka-Patynowski, et al. Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins. J Biol Chem. 1999 Dec 31;274(53):37809-14.

RGD peptide (GRGDNP)

发表于由

RGD peptide (GRGDNP);

RGD peptide (GRGDNP) 作为整合素-配体相互作用的抑制剂，在细胞黏附、迁移、生长和分化中发挥重要作用。RGD peptide (GRGDNP) 通过激活构象变化促进细胞凋亡，从而增强caspase-3的活化。

RGD peptide (GRGDNP)amp;;

RGD peptide (GRGDNP) Chemical Structure

CAS No. : 114681-65-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

RGD peptide (GRGDNP) 的其他形式现货产品:

RGD peptide (GRGDNP) (TFA)

生物活性

RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation[1]. RGD peptide (GRGDNP) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing[2][3].

分子量

614.61

Formula

C23H38N10O10
CAS 号

114681-65-1
Sequence

Gly-Arg-Gly-Asp-Asn-Pro
Sequence Shortening

GRGDNP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ruoslahti, E., and Öbrink, B. Common principles in cell adhesion Experimental Cell Research 227, 1-11 (1996).

    [2]. Meredith JE Jr, et al. Integrins, adhesion and apoptosis. Trends Cell Biol. 1997 Apr;7(4):146-50.

    [3]. Yang W, et al. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1. J Biol Chem. 1999 Mar 26;274(13):8524-30.

RGD

发表于由

RGD;

RGD 是一种三肽，能够有效的引起细胞黏着，定位某种特定细胞系并产生特定的细胞反应；能够与 integrins 结合。

RGDamp;;

RGD Chemical Structure

CAS No. : 99896-85-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

RGD 的其他形式现货产品:

RGD Trifluoroacetate

生物活性

RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

IC50 Target

Integrin[1]
体外研究
(In Vitro)

RGD is the most effective and most often employed peptide sequence for stimulated cell adhesion on synthetic surfaces. There are 24 integrins binding to ECM molecules in a RGD dependent manner: α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

346.34

Formula

C12H22N6O6
CAS 号

99896-85-2
Sequence

Arg-Gly-Asp
Sequence Shortening

RGD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hersel U, et al. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003 Nov;24(24):4385-415.

RGD Trifluoroacetate

发表于由

RGD Trifluoroacetate; 纯度: ge;98.0%

RGD Trifluoroacetate 是一种三肽，能够有效的引起细胞黏着，定位某种特定细胞系并产生特定的细胞反应；RGD Trifluoroacetate 能够与 integrins 结合。

RGD Trifluoroacetateamp;;

RGD Trifluoroacetate Chemical Structure

CAS No. : 2378808-45-6

规格 价格 是否有货 数量
5 mg ￥700 In-stock
10 mg ￥1200 In-stock
25 mg ￥2400 In-stock
50 mg ￥3800 In-stock
100 mg ￥5800 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

RGD Trifluoroacetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.

IC50 Target

Integrin[1]
体外研究
(In Vitro)

RGD Trifluoroacetate is the most effective and most often employed peptide sequence for stimulated cell adhesion on synthetic surfaces. There are 24 integrins binding to ECM molecules in a RGD dependent manner: α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

460.36

Formula

C14H23F3N6O8
CAS 号

2378808-45-6
Sequence

Arg-Gly-Asp
Sequence Shortening

RGD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 60 mg/mL (130.33 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1722 mL 10.8611 mL 21.7221 mL
5 mM 0.4344 mL 2.1722 mL 4.3444 mL
10 mM 0.2172 mL 1.0861 mL 2.1722 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hersel U, et al. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003 Nov;24(24):4385-415.

RGD peptide (GRGDNP) (TFA)

发表于由

RGD peptide (GRGDNP) (TFA); 纯度: 99.25%

RGD peptide (GRGDNP) (TFA)作为整合素-配体相互作用的抑制剂，在细胞黏附、迁移、生长和分化中发挥重要作用。RGD peptide (GRGDNP) (TFA)通过激活构象变化促进细胞凋亡，从而增强caspase-3的活化。

RGD peptide (GRGDNP) (TFA)amp;;

RGD peptide (GRGDNP) (TFA) Chemical Structure

规格 价格 是否有货 数量
1 mg ￥600 In-stock
5 mg ￥1200 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

RGD peptide (GRGDNP) (TFA) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

RGD peptide (GRGDNP) (TFA) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation[1]. RGD peptide (GRGDNP) (TFA) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing[2][3].

分子量

728.63

Formula

C25H39F3N10O12
Sequence

Gly-Arg-Gly-Asp-Asn-Pro
Sequence Shortening

GRGDNP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (68.62 mM)

DMSO : ≥ 50 mg/mL (68.62 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3724 mL 6.8622 mL 13.7244 mL
5 mM 0.2745 mL 1.3724 mL 2.7449 mL
10 mM 0.1372 mL 0.6862 mL 1.3724 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ruoslahti, E., and Öbrink, B. Common principles in cell adhesion Experimental Cell Research 227, 1-11 (1996).

    [2]. Meredith JE Jr, et al. Integrins, adhesion and apoptosis. Trends Cell Biol. 1997 Apr;7(4):146-50.

    [3]. Yang W, et al. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1. J Biol Chem. 1999 Mar 26;274(13):8524-30.