标签归档：riboside

Allopurinol riboside(Synonyms: 别嘌呤醇核糖苷)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Allopurinol riboside;(Synonyms: 别嘌呤醇核糖苷) 纯度: ge;98.0%

Allopurinol riboside是别嘌呤醇的代谢物，能有效地抑制寄生虫。

Allopurinol riboside(Synonyms: 别嘌呤醇核糖苷)

Allopurinol riboside Chemical Structure

CAS No. : 16220-07-8

规格 价格 是否有货 数量
5 mg ￥1200 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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生物活性

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Allopurinol-riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM. Lymphocyte blastogensis induced by PHA and Con A is significantly suppressed by allopurinol-riboside in a concentration-dependent manner. When LPS is used as a mitogen, the inhibition of allopurinol-ribosideon lymphocyte proliferation is less marked. Humoral immunity is not suppressed by allopurinol-riboside[1]. Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Allopurinol riboside is effective against parasites, because a series of enzymes (analogous to those that mediate purine salvage in humans) convert it into 4-aminopyrazolopyrimidine ribonucleoside triphosphate, a cytotoxic product. Allopurinol riboside is selectively toxic, because it is not metabolized by the corresponding enzymes in humans[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range[3]. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

268.23

Formula

C10H12N4O5
CAS 号

16220-07-8
中文名称

别嘌呤醇核糖苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9(5-6):549-52.

    [2]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.

    [3]. Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49(5):506-14.

    [4]. Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37(5):1193-6.

Phytotech Z899-1G ZEATIN RIBOSIDE 玉米素核苷（反式） 1G

发表于由

上海金畔生物科技有限公司提供Phytotech Z899-1G ZEATIN RIBOSIDE 玉米素核苷（反式） 1G，欢迎访问官网了解更多产品信息和订购

品牌 货号 产品名称 规格 价格

Phytotech Z899-1G ZEATIN RIBOSIDE 玉米素核苷（反式） 1G 49855.00

Phytotech A296-25KG AGAR 琼脂 25KG 48533.00

Phytotech P679-10G DL-PHOSPHINOTHRICIN DL-草胺膦/草丁膦（PPT/Basta） 10G 41299.00

Phytotech A111-25KG AGAR, MICROPROPAGATION 琼脂 25KG 34121.00

Phytotech A175-5KG TC AGAR 高纯度琼脂 5KG 32448.00

Phytotech G3251-5KG GELZAN 结冷胶 5KG 24257.00

Phytotech A296-10KG AGAR 琼脂 10KG 22634.00

Phytotech A123-1G ANCYMIDOL 嘧啶醇/醇草啶 1G 21983.00

Phytotech Z125-1G ZEATIN 玉米素（反式） 1G 18888.00

Phytotech D525-25G 6-y,y-DIMETHYLALLYLAMINOPURINE N6-异戊烯基腺嘌呤（2iP） 25G 18777.00

Phytotech A102-5G (+/-) ABSCISIC ACID 脱落酸（ABA） 5G 18220.00

Phytotech G500-100G GIBBERELLIC ACID 赤霉素GA3 100G 17725.00

Phytotech A175-2.5KG TC AGAR 高纯度琼脂 2.5KG 17688.00

Phytotech A111-10KG AGAR, MICROPROPAGATION 琼脂 10KG 15867.00

Phytotech M588-25KG D-MALTOSE 25KG 14396.00

Phytotech I538-1KG INDOLE-3-BUTYRIC ACID 吲哚丁酸（IBA） 1KG 13778.00

Phytotech Z899-250MG ZEATIN RIBOSIDE 玉米素核苷（反式） 250MG 13700.00

Phytotech A296-5KG AGAR 琼脂 5KG 13005.00

Phytotech C346-100G CARBENICILLIN 羧苄青霉素（Car） 100G 12495.00

Phytotech V870-25G VANCOMYCIN HYDROCHLORIDE 盐酸万古霉素 25G 12285.00

Zeatin Riboside (trans isomer) 玉米素核糖苷 品牌：FUJIFILM Wako

发表于由

Zeatin Riboside (trans isomer)

玉米素核糖苷

品牌：FUJIFILM Wako
CAS No.：6025-53-2
储存条件：-20℃
纯度：95.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

262-01081

 for Biochemistry 10mg – 990.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

6-Chloropurine Riboside 5′-Monophosphate Disodium Salt 6-氯嘌呤核苷5′-单磷酸盐 品牌：FUJIFILM Wako

发表于由

6-Chloropurine Riboside 5′-Monophosphate Disodium Salt

6-氯嘌呤核苷5′-单磷酸盐

品牌：FUJIFILM Wako
CAS No.：34258-06-5
储存条件：-20℃
纯度：85.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

038-14671

 for Plant Tissue Culture 10 mg –

6-Chloropurine Riboside 5

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


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Nicotinamide riboside chloride(Synonyms: 烟酰胺核糖氯酸盐)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Nicotinamide riboside chloride;(Synonyms: 烟酰胺核糖氯酸盐) 纯度: 99.53%

Nicotinamide riboside Chloride 是具有口服活性的 NAD+ 的前体，增加 NAD+ 水平并激活 SIRT1 和 SIRT3。Nicotinamide riboside Chloride 是维生素 B3 (烟酸) 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。Nicotinamide riboside Chloride 可以减少阿尔茨海默氏病转基因小鼠模型中的认知退化。

Nicotinamide riboside chloride(Synonyms: 烟酰胺核糖氯酸盐)

Nicotinamide riboside chloride Chemical Structure

CAS No. : 23111-00-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Nicotinamide riboside chloride 相关产品

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  • Rare Diseases Drug Library

生物活性

Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 Target[1]

SIRT1

;

SIRT3

;

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 nM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.

体内研究
(In Vivo)

Chronic Nicotinamide riboside Chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: PO; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.

Clinical Trial

分子量

290.70

Formula

C11H15ClN2O5
CAS 号

23111-00-4
中文名称

烟酰胺核糖氯酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 125 mg/mL (430.00 mM; Need ultrasonic)

DMSO : 50 mg/mL (172.00 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4400 mL 17.1999 mL 34.3997 mL
5 mM 0.6880 mL 3.4400 mL 6.8799 mL
10 mM 0.3440 mL 1.7200 mL 3.4400 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.

    [2]. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer’s Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8.

    [3]. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.

Adenosine(Synonyms: 腺苷; Adenine riboside; D-Adenosine)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Adenosine;(Synonyms: 腺苷; Adenine riboside; D-Adenosine) 纯度: 99.92%

Adenosine (Adenine riboside) 是一种普遍存在的内源性分泌物，是通过四种G蛋白偶联受体（A1、A2A、A2B 和 A3）的起作用。Adenosine 几乎影响细胞生理学的所有方面，包括神经元活动、血管功能、血小板聚集和血细胞调节。

Adenosine(Synonyms: 腺苷; Adenine riboside; D-Adenosine)

Adenosine Chemical Structure

CAS No. : 58-61-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥500 In-stock
500 mg ￥350 In-stock
1 g ￥465 In-stock
5 g ￥650 In-stock
10 g ; 询价 ;
50 g ; 询价 ;

* Please select Quantity before adding items.

Adenosine 相关产品

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生物活性

Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Adenosine (Adenine riboside) acts on four G-protein coupled receptors: two of them, A1 and A3, are primarily coupled to Gi family G proteins; and two of them, A2A and A2B, are mostly coupled to Gs like G proteins. These receptors are antagonized by xanthines including caffeine. Via these receptors it affects many cells and organs, usually having a cytoprotective function[2].
Adenosine is an extracellular signaling molecule that is generated from its precursor molecules 5’-adenosine triphosphate (ATP) and 5’-adenosine monophosphate (AMP)[3].
Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations.Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells[4].
Adenosine induces apoptosis in a variety of cancer cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells. In HepG2 cell lines, Adenosine -induced AMPK/mTOR pathway activation partially blocked ER stress and decreased apoptotic cell death[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

267.24

Formula

C10H13N5O4
CAS 号

58-61-7
中文名称

腺苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 33.33 mg/mL (124.72 mM; Need ultrasonic)

H2O : ≥ 6.67 mg/mL (24.96 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7420 mL 18.7098 mL 37.4195 mL
5 mM 0.7484 mL 3.7420 mL 7.4839 mL
10 mM 0.3742 mL 1.8710 mL 3.7420 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323.

    [2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625.

    [3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915.

    [4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838.