标签归档：rusalatide

Rusalatide acetate(Synonyms: TP508 amide acetate)

发表于由

Rusalatide acetate;(Synonyms: TP508 amide acetate) 纯度: 98.26%

Rusalatide acetate (TP508 amide acetate) 是一种再生肽，能够激活干细胞再生修复以及保护隐窝完整性，达到减缓辐照引起的胃肠道损伤。

Rusalatide acetateamp;;(Synonyms: TP508 amide acetate)

Rusalatide acetate Chemical Structure

CAS No. : 875455-82-6

规格 价格 是否有货 数量
1 mg ￥2100 In-stock
5 mg ￥4800 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Rusalatide acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Rusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity[1].

体外研究
(In Vitro)

Rusalatide (TP508) is a 23 amino acid peptide representing amino acids 508-530 of human prothrombin that was identified as the high-affinity binding domain of thrombin responsible for interaction with a subset of thrombin receptors on the surface of fibroblasts thought to initiate tissue repair[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2371.50

Formula

C99H151N29O37S
CAS 号

875455-82-6
Sequence Shortening

AGYKPDEGKRGDACEGDSGGPFV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Kantara C, et al. Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. Lab Invest. 2015 Nov;95(11):1222-33.