Saikosaponin H(Synonyms: 柴胡皂苷H)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin H;(Synonyms: 柴胡皂苷H)

Saikosaponin H 是从草药柴胡中提取的一种柴胡皂苷。

Saikosaponin H(Synonyms: 柴胡皂苷H)

Saikosaponin H Chemical Structure

CAS No. : 91990-63-5

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Saikosaponin H is a saikosaponin derived from the herb Radix bupleuri[1].

分子量

927.12

Formula

C48H78O17

CAS 号

91990-63-5

中文名称

柴胡皂苷H

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bao Y, et al. Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the chinese multiherb remedy xiaochaihu-tang using liquid chromatographic tandem massspectrometry. Anal Chem. 2004 Jul 15;76(14):4208-16.

Saikosaponin D(Synonyms: 柴胡皂苷D)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin D;(Synonyms: 柴胡皂苷D) 纯度: 98.76%

Saikosaponin D 是从柴胡中分离到的三萜皂苷类,具有抗炎,抗菌,抗肿瘤,抗过敏的功效;Saikosaponin D 可以抑制 selectinSTAT3NF-kB 的活性,活化 estrogen receptor-β

Saikosaponin D(Synonyms: 柴胡皂苷D)

Saikosaponin D Chemical Structure

CAS No. : 20874-52-6

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ¥773 In-stock
5 mg ¥600 In-stock
10 mg ¥900 In-stock
25 mg ¥1800 In-stock
50 mg ¥2900 In-stock
100 mg ¥5200 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

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  • Anti-Liver Cancer Compound Library

生物活性

Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

IC50 Target[2][3]

NF-κB

;

STAT3

;

ERβ

;

体外研究
(In Vitro)

Saikosaponin D (Compound 3) is a triterpene saponin, which inhibits E-selectin, L-selectin and P-selectin binding to THP-1 cells, with IC50s of 1.8 µM, 3.0 µM and 4.3 µM, and such effects are not due to cytotoxic action. Saikosaponin D (1, 5, 10 µM) dose-dependently inhibits the THP-1 adhesion to the HUVECs monolayer activated by TNF-α. Saikosaponin D (30 μM) also inhibits the expression of P-selectin ligand (CD162) in THP-1 cells[1]. Saikosaponin D (5 μM) suppresses the proliferation of HSC-T6 cells induced by H2O2 treatment, reduces the expression levels of α-SMA, TGF-β1, Hyp, COL1 and TIMP-1, and increases MMP-1 expressioon, thus inhibiting H2O2-induced excessive extracellular matrix (ECM) formation, with similar effects to estradiol (E2), and these effects are blocked by ER antagonists. Saikosaponin D also inhibits oxidative stress-induced ROS generation and down reduates MAPK signaling pathway, and the inhibition is also suppressed by ER antagonists[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Saikosaponin D (2 mg/kg/day, i.p.) shows a protective effect on overdose of acetaminophen (APAP)-induced liver injury of mice. Saikosaponin D affects APAP metabolism, increases GSH levels but does not alter PPARα activation. Saikosaponin D (2 mg/kg/day, i.p.) also suppresses APAP-induced increases in the expression of STAT3 target genes and pro-inflammatory cytokines and inhibits APAP-induced activation of STAT3 and NF-kB[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

780.98

Formula

C42H68O13

CAS 号

20874-52-6

中文名称

柴胡皂苷D;柴胡皂甙D

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 50 mg/mL (64.02 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2804 mL 6.4022 mL 12.8044 mL
5 mM 0.2561 mL 1.2804 mL 2.5609 mL
10 mM 0.1280 mL 0.6402 mL 1.2804 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Jang MJ, et al. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules. 2014 Dec 4;19(12):20340-9.

    [2]. Liu A, et al. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 5;223:80-6.

    [3]. Que R, et al. Estrogen receptor-β-dependent effects of saikosaponin‑d on the suppression of oxidative stress-induced rat hepatic stellate cell activation. Int J Mol Med. 2018 Mar;41(3):1357-1364.

Cell Assay
[1]

Cell viability is assessed by morphology and by reduction of the tetrazolium salt (MTT). Briefly, the THP-1 cells (2 × 105 cells/well) and various concentrations of compounds 1-4 (including Saikosaponin D) are added to the 96-well plates, incubated for 48 h at 37°C, and 5 µL of MTT solution (5 mg/mL in PBS) is added to each well of the 96-well plates. After incubation for 4 h at 37°C, the absorbance is measured at 540 nm using a microplate reader with the reference absorbance at 650 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Mice[2]
Male 6- to 7-week-old C57BL6 mice are randomly divided into four groups, vehicle/control, Saikosaponin D (SSd)/control, vehicle/APAP, and SSd/APAP, and killed 4 h or 24 h after single APAP injection. For overdose of acetaminophen (APAP) injection, a typical single dose of 200 mg/kg/day is used. Saikosaponin D, 2 mg/kg once daily is used as the dosing regimen. Saikosaponin D powder is dissolved in a saline solution supplemented with 0.1% Tween 20 and is administered by intraperitoneal injection at a dose of 2 mg/kg/day once daily for five days. Saline solution containing 0.1% Tween 20 without Saikosaponin D is administered as a vehicle. APAP is dissolved in warm saline solution (20 mg/mL) and is injected intraperitoneally 30 minutes after the last Saikosaponin D injection. Saline is injected to mice in the control groups[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Jang MJ, et al. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules. 2014 Dec 4;19(12):20340-9.

    [2]. Liu A, et al. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 5;223:80-6.

    [3]. Que R, et al. Estrogen receptor-β-dependent effects of saikosaponin‑d on the suppression of oxidative stress-induced rat hepatic stellate cell activation. Int J Mol Med. 2018 Mar;41(3):1357-1364.

Saikosaponin A(Synonyms: 柴胡皂苷 A)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin A;(Synonyms: 柴胡皂苷 A) 纯度: 99.43%

Saikosaponin A 是从银柴胡中的主要活性成分,可上调 LXRα 的表达,具有有效抗炎活性。

Saikosaponin A(Synonyms: 柴胡皂苷 A)

Saikosaponin A Chemical Structure

CAS No. : 20736-09-8

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ¥1289 In-stock
5 mg ¥850 In-stock
10 mg ¥1500 In-stock
25 mg ¥3000 In-stock
50 mg ¥5000 In-stock
100 mg ¥8500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

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bull;相关化合物库:

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生物活性

Saikosaponin A is an active component of Bupleurum falcatum, up-regulates LXRα expression, with potent anti-inflammatory activity[1].

分子量

780.98

Formula

C42H68O13

CAS 号

20736-09-8

中文名称

柴胡皂苷 A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (128.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2804 mL 6.4022 mL 12.8044 mL
5 mM 0.2561 mL 1.2804 mL 2.5609 mL
10 mM 0.1280 mL 0.6402 mL 1.2804 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Gao H, et al. Saikosaponin A inhibits IL-1β-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXRα. Oncotarget. 2017 Sep 30;8(51):88941-88950.

Saikosaponin C(Synonyms: 柴胡皂苷 C)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin C;(Synonyms: 柴胡皂苷 C) 纯度: 99.65%

Saikosaponin C 是柴胡中的活性成分,在阿尔滋海默症中主要靶作用于 amyloid betatau 蛋白。Saikosaponin C 抑制 Aβ1-40 和 Aβ1-42 的释放,抑制异常 tau 蛋白的磷酸化,但对 BACE1 的活性和表达无作用。

Saikosaponin C(Synonyms: 柴胡皂苷 C)

Saikosaponin C Chemical Structure

CAS No. : 20736-08-7

规格 价格 是否有货 数量
5 mg ¥800 In-stock
10 mg ¥1400 In-stock
20 mg ¥2300 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

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  • Natural Product Library Plus
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  • Anti-Alzheimer’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Targeted Diversity Library

生物活性

Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer’s disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression[1].

分子量

927.12

Formula

C48H78O17

CAS 号

20736-08-7

中文名称

柴胡皂苷 C

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (107.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0786 mL 5.3930 mL 10.7861 mL
5 mM 0.2157 mL 1.0786 mL 2.1572 mL
10 mM 0.1079 mL 0.5393 mL 1.0786 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (2.70 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.70 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.70 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.70 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.70 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.70 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Lee TH1, et al. A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent. J Neurochem. 2016 Mar;136(6):1232-1245.

Saikosaponin B1(Synonyms: 柴胡皂苷 B1)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin B1;(Synonyms: 柴胡皂苷 B1) 纯度: 99.42%

Saikosaponin B1 是一种柴胡的生物活性成分,具有抗癌活性。Saikosaponin B1 通过靶向 SMO 抑制 Hedgehog 通路,显著抑制髓母细胞瘤 (MB) 模型中的肿瘤生长。

Saikosaponin B1(Synonyms: 柴胡皂苷 B1)

Saikosaponin B1 Chemical Structure

CAS No. : 58558-08-0

规格 价格 是否有货 数量
5 mg ¥1600 In-stock
10 mg ¥2700 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Saikosaponin B1 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Stem Cell Signaling Compound Library
  • Wnt/Hedgehog/Notch Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Differentiation Inducing Compound Library
  • Glycoside Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO[1].

分子量

780.98

Formula

C42H68O13

CAS 号

58558-08-0

中文名称

柴胡皂苷 B1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (128.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2804 mL 6.4022 mL 12.8044 mL
5 mM 0.2561 mL 1.2804 mL 2.5609 mL
10 mM 0.1280 mL 0.6402 mL 1.2804 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 100 mg/mL (128.04 mM); Clear solution

    此方案可获得 ≥ 100 mg/mL (128.04 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 1000.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: 10 mg/mL (12.80 mM); Clear solution; Need ultrasonic

    此方案可获得 10 mg/mL (12.80 mM) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 10 mg/mL (12.80 mM); Clear solution

    此方案可获得 ≥ 10 mg/mL (12.80 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Luo J, et al. Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway [published online ahead of print, 2022 Feb 16]. J Nat Med. 2022;10.1007/s11418-022-01603-8.

Saikosaponin B2(Synonyms: 柴胡皂苷 B2)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin B2;(Synonyms: 柴胡皂苷 B2) 纯度: 98.76%

Saikosaponin B2 是从柴胡根中分离得到的活性成分,为 HCV 病毒感染的侵入抑制剂。抗癌作用。

Saikosaponin B2(Synonyms: 柴胡皂苷 B2)

Saikosaponin B2 Chemical Structure

CAS No. : 58316-41-9

规格 价格 是否有货 数量
5 mg ¥990 In-stock
10 mg ¥1680 In-stock
20 mg ¥2860 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Saikosaponin B2 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antiviral Compound Library
  • Glycoside Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Hepatitis C Virus Compound Library

生物活性

Saikosaponin B2 is an active component from Bupleurum kaoi root, acts as an entry inhibitor against HCV infection[1]. Anti-cancer activity[2].

分子量

780.98

Formula

C42H68O13

CAS 号

58316-41-9

中文名称

柴胡皂苷 B2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (128.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2804 mL 6.4022 mL 12.8044 mL
5 mM 0.2561 mL 1.2804 mL 2.5609 mL
10 mM 0.1280 mL 0.6402 mL 1.2804 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.20 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Lin LT, et al. Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. J Hepatol. 2015 Mar;62(3):541-8.

    [2]. Ma Q, et al. Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration. Mol Med Rep. 2019 Aug;20(2):1943-1951.

Saikosaponin E(Synonyms: 柴胡皂苷E)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin E;(Synonyms: 柴胡皂苷E) 纯度: 99.80%

Saikosaponin E 是一种从 Bupleurum yinchowense 中分离得到的一种柴胡皂苷。

Saikosaponin E(Synonyms: 柴胡皂苷E)

Saikosaponin E Chemical Structure

CAS No. : 64340-44-9

规格 价格 是否有货
5 mg ¥4030 询问价格 货期
10 mg ¥6860 询问价格 货期

* Please select Quantity before adding items.

生物活性

Saikosaponin E is a saikosaponin isolated from Bupleurum yinchowense[1].

分子量

764.98

Formula

C42H68O12

CAS 号

64340-44-9

中文名称

柴胡皂苷E

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. LI Zong yang, et al. Cytotoxic saikosaponins from Bupleurum yinchowense. Journal of Medicinal Plants Research Vol.6 (27), pp. 4409-4415, 18 July, 2012.

Saikosaponin B4

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin B4; 纯度: 99.04%

Saikosaponin B4 是柴胡皂苷 (B. falcatum) 的一种,从柴胡的根中分离得到,选择性地抑制 ACTH 诱导的脂解作用。

Saikosaponin B4

Saikosaponin B4 Chemical Structure

CAS No. : 58558-09-1

规格 价格 是否有货 数量
5 mg ¥2020 In-stock
10 mg ¥3430 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Saikosaponin B4 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library

生物活性

Saikosaponin B4 is a member of saikosaponins isolated from the roots of B. falcatum, selectively inhibits ACTH-induced lipolysis[1].

分子量

813.02

Formula

C43H72O14

CAS 号

58558-09-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. Jang MJ, et al. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules. 2014 Dec 4;19(12):20340-9.

    [2]. Kimura Y, et al. Effects of saikosaponins on the metabolic actions of adrenaline, ACTH and insulin on the fat cells. Chem Pharm Bull (Tokyo). 1980 Jun;28(6):1788-94.

Saikosaponin G

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin G;

Saikosaponin G 是一种从柴胡中分离得到的三萜苷类化合物。

Saikosaponin G

Saikosaponin G Chemical Structure

CAS No. : 99365-19-2

规格 价格 是否有货
1 mg ¥3430 询问价格 货期
5 mg ¥10290 询问价格 货期

* Please select Quantity before adding items.

生物活性

Saikosaponin G is a triterpene glycoside isolated from Bupleuri Radix[1].

分子量

780.98

Formula

C42H68O13

CAS 号

99365-19-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shimizu K, et al. Structural transformation of saikosaponins by gastric juice and intestinal flora. J Pharmacobiodyn. 1985 Sep;8(9):718-25.

Saikosaponin F(Synonyms: 柴胡皂苷 F)

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin F;(Synonyms: 柴胡皂苷 F)

Saikosaponin F 是柴胡中的成分之一。

Saikosaponin F(Synonyms: 柴胡皂苷 F)

Saikosaponin F Chemical Structure

CAS No. : 62687-63-2

规格 价格 是否有货
5 mg ¥5040 询问价格 货期
10 mg ¥8570 询问价格 货期

* Please select Quantity before adding items.

生物活性

Saikosaponin F is a component found in Bupleurum (B.) falcatum L[1].

分子量

929.14

Formula

C48H80O17

CAS 号

62687-63-2

中文名称

柴胡皂苷 F

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nakahara Y, et al. Oleanene glycosides of the aerial parts and seeds of Bupleurum falcatum and the aerial parts of Bupleurum rotundifolium, and their evaluation as anti-hepatitis agents. Chem Pharm Bull (Tokyo). 2011;59(11):1329-39.