Kizuta saponin K11

天然产物 糖类和糖苷 Saccharides and Glycosides

Kizuta saponin K11;

Kizuta saponin K11 是一种存在于 Kalopanax pictum var. maximowiczii 叶子中的皂苷。Kalopanax pictum var. maximowiczii 是一种韩国药用植物。

Kizuta saponin K11

Kizuta saponin K11 Chemical Structure

CAS No. : 97240-03-4

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生物活性

Kizuta saponin K11 is a saponin found in the leaves of Kalopanax pictum var. maximowiczii, a Korean medicinal plant[1].

分子量

1263.41

Formula

C61H98O27

CAS 号

97240-03-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hahn DR, et al. Saponins from leaves of Kalopanax pictum var. maximowiczii, a Korean medicinal plant. Chem Pharm Bull (Tokyo). 1989;37(8):2234-2235.

Pulsatilla saponin D(Synonyms: SB365; Hederacolchiside A)

天然产物 糖类和糖苷 Saccharides and Glycosides

Pulsatilla saponin D;(Synonyms: SB365; Hederacolchiside A) 纯度: 98.47%

Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到,具有抗癌活性。

Pulsatilla saponin D(Synonyms: SB365;  Hederacolchiside A)

Pulsatilla saponin D Chemical Structure

CAS No. : 68027-15-6

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ¥3977 In-stock
5 mg ¥1980 In-stock
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50 mg ; 询价 ;

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生物活性

Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana Nakai, is an anti-tumor agent[1][2][3][4].

体外研究
(In Vitro)

Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase[1].
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells[1].
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) [2].
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF[3].
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[4]

Cell Line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells.
Concentration: 0.3 ng/mL to 10 μg/mL.
Incubation Time: 72 h.
Result: Exhibited an ED50 value of 6.3 μg/mL for A-549 cells.

体内研究
(In Vivo)

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice[4].
Dosage: 6.4 mg/kg.
Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).

分子量

913.10

Formula

C47H76O17

CAS 号

68027-15-6

中文名称

白头翁皂苷 D

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : ≥ 39 mg/mL (42.71 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0952 mL 5.4759 mL 10.9517 mL
5 mM 0.2190 mL 1.0952 mL 2.1903 mL
10 mM 0.1095 mL 0.5476 mL 1.0952 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (2.28 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.28 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.28 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.28 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.28 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.28 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Hong SW, et al. SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. Carcinogenesis. 2013 Sep;34(9):2156-69.

    [2]. Son MK, et al. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Oncol Rep. 2013 Aug;30(2):801-8.

    [3]. Son MK, et al. SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. Food Chem. 2013 Jan 1;136(1):26-33.

    [4]. Yong Kim, et al. Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana. Arch Pharm Res. 2004 Sep;27(9):915-8.

Saponin PE

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Saponin PE 

Saponin PE 是从铁线莲地上部分中分离得到的皂苷类化合物。

Saponin PE

Saponin PE Chemical Structure

CAS No. : 60213-69-6

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生物活性

Saponin PE is a saponin compound isolated from aerial part of Clematis tangutica[1].

分子量

750.96

Formula

C41H66O12

CAS 号

60213-69-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhong HM, et al. Triterpenoid saponins from Clematis tangutica. Planta Med. 2001;67(5):484-488.

Paris saponin VII(Synonyms: 重楼皂苷 VII; Chonglou Saponin VII)

天然产物 糖类和糖苷 Saccharides and Glycosides

Paris saponin VII;(Synonyms: 重楼皂苷 VII; Chonglou Saponin VII) 纯度: 99.13%

Paris saponin VII (Chonglou Saponin VII) 是从延龄草 (Trillium tschonoskii Maxim) 的根和根茎中分离的甾体皂苷。Paris saponin VII 诱导的 K562/ADR 细胞凋亡与 Akt/p38 MAPKP-gp 的抑制有关。Paris saponin VII 减弱线粒体膜电位,增加凋亡相关蛋白 (Bax 和细胞色素 c) 的表达,并降低 Bcl-2caspase-9caspase-3PARP-1p-Akt 的蛋白表达水平。Paris saponin VII 在 K562/ADR 细胞中诱导强烈的自噬,可用于白血病的研究。

Paris saponin VII(Synonyms: 重楼皂苷 VII; Chonglou Saponin VII)

Paris saponin VII Chemical Structure

CAS No. : 68124-04-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
5 mg ¥1350 In-stock
10 mg ¥2300 In-stock
50 mg ; 询价 ;
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* Please select Quantity before adding items.

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生物活性

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].

IC50 Target[1]

Akt

;

p38

;

Bcl-2

;

Caspase-9

;

Caspase-3

;

PARP-1

;

体外研究
(In Vitro)

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1031.18

Formula

C51H82O21

CAS 号

68124-04-9

中文名称

重楼皂苷 VII

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (96.98 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9698 mL 4.8488 mL 9.6976 mL
5 mM 0.1940 mL 0.9698 mL 1.9395 mL
10 mM 0.0970 mL 0.4849 mL 0.9698 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.42 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.42 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.42 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Yan T, et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907.

    [2]. Li Y, et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54.

Saponin CP6(Synonyms: Clematoside S; Prosapogenin CP6)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Saponin CP6 (Synonyms: Clematoside S; Prosapogenin CP6)

Saponin CP6 是一种来自 Clematis grata 根部的三萜类化合物。

Saponin CP6(Synonyms: Clematoside S;  Prosapogenin CP6)

Saponin CP6 Chemical Structure

CAS No. : 72629-76-6

规格 是否有货
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250 mg   询价  
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生物活性

Saponin CP6 is a triterpenoid compound from the roots of Clematis grata[1].

分子量

883.07

Formula

C46H74O16

CAS 号

72629-76-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sati OP, et al. Clematoside-S, a triterpenoid saponin from the roots of Clematis grata. Phytochemistry. 1990;29(11):3676-3678.

Saponin CP4(Synonyms: Prosapogenin CP4)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Saponin CP4 (Synonyms: Prosapogenin CP4)

Saponin CP4 是一种缺乏 23-OH 的齐墩果酸衍生物。Saponin CP4 无生长抑制作用。

Saponin CP4(Synonyms: Prosapogenin CP4)

Saponin CP4 Chemical Structure

CAS No. : 75799-18-7

规格 是否有货
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250 mg   询价  
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生物活性

Saponin CP4 is an oleanolic acid derivative which lacks a 23-OH. Saponin CP4 shows no growth inhibition[1].

分子量

867.07

Formula

C46H74O15

CAS 号

75799-18-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yukiyoshi Tamura, et al. Application of Saponin-Containing Plants in Foods and Cosmetics.

Clematomandshurica saponin C

天然产物 糖类和糖苷 Saccharides and Glycosides

Clematomandshurica saponin C;

Clematomandshurica saponin C 存在于东北铁线莲中。

Clematomandshurica saponin C

Clematomandshurica saponin C Chemical Structure

CAS No. : 916649-92-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Clematomandshurica saponin C is found in Clematis manshurica[1].

分子量

1661.77

Formula

C76H124O39

CAS 号

916649-92-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang J X, et al. Study on triterpenoid glycosides from roots of Clematis manshurica[J]. Chinese Traditional and Herbal Drugs, 2019.

Pulsatilla saponin H(Synonyms: Hederacolchiside F)

天然产物 糖类和糖苷 Saccharides and Glycosides

Pulsatilla saponin H;(Synonyms: Hederacolchiside F)

Pulsatilla saponin H 是可从Pulsatilla koreana 根部分离得到的一种天然化合物。

Pulsatilla saponin H(Synonyms: Hederacolchiside F)

Pulsatilla saponin H Chemical Structure

CAS No. : 68027-14-5

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pulsatilla saponin H is a natural compound isolated from the Roots of Pulsatilla koreana[1].

分子量

1383.52

Formula

C65H106O31

CAS 号

68027-14-5

中文名称

白头翁皂苷 H

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sam Sik Kang, et al. Saponins from the Roots of Pulsatilla koreana. Arch. Pharm Res. 12(1), 42-47 (1989).

Clematomandshurica saponin B

天然产物 糖类和糖苷 Saccharides and Glycosides

Clematomandshurica saponin B;

Clematomandshurica saponin B 对环氧合酶-2有显著抑制作用 (IC50=2.58 mM)。

Clematomandshurica saponin B

Clematomandshurica saponin B Chemical Structure

CAS No. : 916649-91-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Clematomandshurica saponins B shows significant inhibitory activity on cyclooxygenase-2 (IC50=2.58 mM)[1].

IC50 Target

COX-2

;

分子量

1984.08

Formula

C92H142O46

CAS 号

916649-91-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shi S, Jiang D, Dong C, Tu P. Triterpene saponins from clematis mandshurica. J Nat Prod. 2006;69(11):1591-1595.