SN52

SN52; 纯度: 98.58%

SN52 是一种有效的、竞争性的、细胞通透性的 NF-κB2 抑制剂。SN52 是 SN50 肽的变体,抑制 p52-RelB 异二聚体的核易位。SN52 对前列腺癌细胞有很强的放射增敏作用。SN52 可以用于癌症研究。

SN52amp;;

SN52 Chemical Structure

CAS No. : 1071173-56-2

规格 价格 是否有货 数量
1 mg ¥2000 In-stock
5 mg ¥5900 In-stock
10 mg ¥9500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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SN52 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research[1].

IC50 Target

IC50: NF-κB2[1]

体外研究
(In Vitro)

SN52 (40 μg/ml; 30 mins before DMXAA) inhibits DMXAA-induced nuclear translocation of RelB in BMDCs[1].
SN52 does not change the activation of canonical NF-κB signaling. The nuclear translocation of RelB is increased in DCs isolated from irradiated tumors, and SN52 abolishes this activation in activated DC cells[1].
SN52 (40 μg/mL; 30 mins before co-cultured with irradiated or non-irradiated MC38 cells) inhibits the non-canonical NF-κB and increases Ifn-b expression in BMDCs stimulated with irradiated tumor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SN52 (intrathecal injection; 40 μg/ml; day-1, day 1 and day 3 of 20Gy radiation of radiation) combines with IR enhances anti-tumor immune functions of both DCs and CD8+ T cells and subsequently reduced tumor burden more effectively compared with IR alone[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tumor mice model[1]
Dosage: 40 μg
Administration: Intrathecal injection; 40 μg; day-1, day 1 and day 3 of 20Gy radiation of radiation
Result: Reduced tumor burden than IR group alone.
Induced non-canonical NF-κB inhibition and potentiates the anti-tumor effect of IR.

分子量

2749.43

Formula

C128H230N38O28

CAS 号

1071173-56-2

Sequence Shortening

AAVALLPAVLLALLAPVQRKRRKALP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

H2O : 25 mg/mL (9.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3637 mL 1.8186 mL 3.6371 mL
5 mM 0.0727 mL 0.3637 mL 0.7274 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Yong Xu, et al. SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther

    [2]. Yuzhu Hou, et al. Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy. Immunity. 2018 Sep 18;49(3):490-503.e4

ChemvakWH-8SN旋片式真空泵

ChemvakWH-8SN旋片式真空泵

Chemvak WH-8SN 旋片式真空泵

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品牌:Chemvak
生产厂家:Chemvak
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ChemvakWH-8SN旋片式真空泵

行安静平稳,维护方便
2.对酸气,水气,有机气体等耐受力强
3.快速到达最低真空压力
4.适合于长时间连续工作标准配件连接简单
5.适用于减压蒸馏,冷冻干燥,脱气及干燥工艺等

 

定货号

型号

类型

流量

(L/min)

最低真空度

(mbar)

马达功率

(W)

噪音

(dB)

加油量

(L)

重量

(kg)

接口规格

168040-22

WH-4SN

单级泵

50

2.5×10-2

180

68

0.3

7

 1/4”SAE Male

168080-22

WH-8SN

单级泵

120

2.5×10-2

370

70

0.65

12

三通接口3/8” SAE Male;1/4”SAE Male;5/16”SAE Male

168012-22

WH-12SN

单级泵

170

2.5×10-2

370

70

0.65

12

三通接口3/8” SAE Male;1/4”SAE Male;5/16”SAE Male

168180-22

WH-8D

双级泵

135

4×10-4

370

68

1.1

27

DN25KF

168017-22

WH-17D

双级泵

283

4×10-4

750

68

1.5

31

DN25KF

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC

生化分析试剂 Biochemical Assay Reagents
1-Oleoyl-2-palmitoyl-sn-glycero-3-PC;

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC 衍生自油酸。1-Oleoyl-2-palmitoyl-sn-glycero-3-PC 可用于脂质体的合成。

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC Chemical Structure

CAS No. : 59491-62-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC derives from an oleic acid. 1-Oleoyl-2-palmitoyl-sn-glycero-3-PC can be used for the synthesis of liposomes[1].

分子量

760.08

Formula

C42H82NO8P

CAS 号

59491-62-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tomita T, et al. Influence of membrane fluidity on the assembly of Staphylococcus aureus alpha-toxin, a channel-forming protein, in liposome membrane. J Biol Chem. 1992;267(19):13391-13397.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol(Synonyms: POPG)

生化分析试剂 Biochemical Assay Reagents
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol;(Synonyms: POPG)

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) 可用于制备细菌膜模拟物。

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol(Synonyms: POPG)

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol Chemical Structure

CAS No. : 185435-28-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol 的其他形式现货产品:

1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)

生物活性

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) can be used to formulate bacterial membrane mimetic[1].

分子量

749.01

Formula

C40H77O10P

CAS 号

185435-28-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pozo Navas B, et al. Composition dependence of vesicle morphology and mixing properties in a bacterial model membrane system. Biochim Biophys Acta. 2005;1716(1):40-48.