Soyasaponin II

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin II  纯度: 99.81%

Soyasaponin II 是具有抗病毒活性的皂苷。Soyasaponin II 抑制 HSV-1,HCMV,流感病毒和 HIV-1 的复制。Soyasaponin II 对 HSV-1 复制显示出有效的抑制作用。Soyasaponin II 作为 YB-1 磷酸化和 NLRP3 炎性小体引发的抑制剂,可保护小鼠免受 LPS/GalN 诱导的急性肝衰竭。

Soyasaponin II

Soyasaponin II Chemical Structure

CAS No. : 55319-36-3

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生物活性

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].

IC50 & Target[1][2]

HSV-1

54 μM (IC50)

HIV-1

112 μM (IC50)

influenza virus

88 μM (IC50)

HCMV

104 μM (IC50)

NLRP3 inflammasome

 

体外研究
(In Vitro)

Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

913.10

Formula

C47H76O17

CAS 号

55319-36-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Hayashi K, et al. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 1997;63(2):102-105.

    [2]. Wang F, et al. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics. 2020;10(6):2714-2726. Published 2020 Feb 3.

Soyasaponin III(Synonyms: 大豆皂苷 III)

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin III;(Synonyms: 大豆皂苷 III) 纯度: 97.72%

Soyasaponin III 是一类单链齐墩果烷三萜类化合物,是大豆 (Glycine max) 及其相关产品中发现的主要潜在生物活性皂苷之一。Soyasaponin III 可以诱导 Hep-G2 细胞凋亡

Soyasaponin III(Synonyms: 大豆皂苷 III)

Soyasaponin III Chemical Structure

CAS No. : 55304-02-4

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Soyasaponin III 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells[1].

分子量

796.98

Formula

C42H68O14

CAS 号

55304-02-4

中文名称

大豆皂苷 III

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. Zhang W, et al. Group B oleanane triterpenoid extract containing soyasaponins I and III from soy flour inducesapoptosis in Hep-G2 cells. J Agric Food Chem. 2010 May 12;58(9):5315-9.

Soyasaponin Bb(Synonyms: 大豆皂苷Bb)

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin Bb;(Synonyms: 大豆皂苷Bb) 纯度: 99.13%

soyasaponin Bb 是从菜豆科中分离出的一种大豆皂苷,能作为醛糖还原酶差异抑制剂 (ARDI)

Soyasaponin Bb(Synonyms: 大豆皂苷Bb)

Soyasaponin Bb Chemical Structure

CAS No. : 51330-27-9

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5 mg ¥1190 In-stock
10 mg ¥2020 In-stock
20 mg ¥3430 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Soyasaponin Bb 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Endocrinology Compound Library
  • Medicine Food Homology Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Food-Sourced Compound Library

生物活性

soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI)[1].

分子量

943.12

Formula

C48H78O18

CAS 号

51330-27-9

中文名称

大豆皂苷Bb

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):350-360.

Soyasaponin Ab(Synonyms: 大豆皂苷Ab)

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin Ab;(Synonyms: 大豆皂苷Ab) 纯度: ge;99.0%

Soyasaponin Ab 是一种大豆皂苷,在 3T3-L1 脂肪细胞中通过下调 PPARγ 产生抗肥胖作用。

Soyasaponin Ab(Synonyms: 大豆皂苷Ab)

Soyasaponin Ab Chemical Structure

CAS No. : 118194-13-1

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5 mg ¥2020 In-stock
10 mg ¥3430 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Soyasaponin Ab 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Obesity Compound Library
  • Food-Sourced Compound Library

生物活性

Soyasaponin Ab is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ)[1].

分子量

1437.52

Formula

C67H104O33

CAS 号

118194-13-1

中文名称

大豆皂苷Ab

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (69.56 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6956 mL 3.4782 mL 6.9564 mL
5 mM 0.1391 mL 0.6956 mL 1.3913 mL
10 mM 0.0696 mL 0.3478 mL 0.6956 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.74 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.74 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.74 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Yang SH, et al. Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ. Phytother Res. 2015 Feb;29(2):281-7.

Soyasaponin IV

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin IV; 纯度: ge;98.0%

Soyasaponin IV 可从 Glycine soya 中分离得到,具有肝脏保护作用。

Soyasaponin IV

Soyasaponin IV Chemical Structure

CAS No. : 108906-97-4

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生物活性

Soyasaponin IV, isolated from the aerial parts of Glycine soya, exhibits a hepatoprotective action[1].

分子量

766.95

Formula

C41H66O13

CAS 号

108906-97-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. J Kinjo, et al. Structure-hepatoprotective relationships study of soyasaponins I-IV having soyasapogenol B as aglycone. Planta Med. 1998 Apr;64(3):233-6.

Soyasaponin Ac(Synonyms: 大豆皂苷Ac)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Soyasaponin Ac (Synonyms: 大豆皂苷Ac)

Soyasaponin Ac 是一种从大豆种子中分离出来的三萜。

Soyasaponin Ac(Synonyms: 大豆皂苷Ac)

Soyasaponin Ac Chemical Structure

CAS No. : 133882-74-3

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25 mg 询价

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生物活性

Soyasaponin Ac is a triterpenoid isolated from the seeds of Glycine max.

分子量

1421.52

Formula

C67H104O32

CAS 号

133882-74-3

中文名称

大豆皂苷Ac

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Soyasaponin Aa(Synonyms: 大豆皂苷Aa)

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin Aa;(Synonyms: 大豆皂苷Aa)

Soyasaponin Aa 是一种大豆皂苷,在 3T3-L1 脂肪细胞中通过下调 PPARγ 产生抗肥胖作用。

Soyasaponin Aa(Synonyms: 大豆皂苷Aa)

Soyasaponin Aa Chemical Structure

CAS No. : 117230-33-8

规格 价格 是否有货
5 mg ¥9000 询问价格 货期

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生物活性

Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ)[1].

分子量

1365.46

Formula

C64H100O31

CAS 号

117230-33-8

中文名称

大豆皂苷Aa

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang SH, et al. Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ. Phytother Res. 2015 Feb;29(2):281-7.

Soyasaponin Ba(Synonyms: 大豆皂苷Ba)

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin Ba;(Synonyms: 大豆皂苷Ba)

Soyasaponin Ba 是一种从菜豆类中分离出的大豆皂苷,能作为醛糖还原酶抑制剂 (ARI)

Soyasaponin Ba(Synonyms: 大豆皂苷Ba)

Soyasaponin Ba Chemical Structure

CAS No. : 114590-20-4

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5 mg ¥2020 询问价格 货期
10 mg ¥3430 询问价格 货期

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生物活性

Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI)[1].

分子量

959.12

Formula

C48H78O19

CAS 号

114590-20-4

中文名称

大豆皂苷Ba

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):350-360.