标签归档：substance

Substance P(1-7)

发表于由

Substance P(1-7);

Substance P(1-7) 是神经肽P物质 (SP) 的片段。Substance P(1-7) 可对孤束核产生抑制和缓和作用。

Substance P(1-7)amp;;

Substance P(1-7) Chemical Structure

CAS No. : 68060-49-1

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Substance P(1-7) 的其他形式现货产品:

Substance P(1-7) TFA

生物活性

Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius[1].

体内研究
(In Vivo)

Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

900.04

Formula

C41H65N13O10
CAS 号

68060-49-1
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe
Sequence Shortening

RPKPQQF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20.

    [2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.
Animal Administration
[1][2]

Rats[1]

Sprague-Dawley male rats weighing 250-300 g are anaesthetized with halothane and placed in a stereotaxic frame. An injection cannula, conically shaped with a penetration tip diameter of approximately 0.15 mm is loared into the SNR. Saline (0.2 μL), SP (0.007-0.7 nmol) or Substance P (1-7) (0.01-1 nmol) is injected into the left substantia nigra, pars reticulata (SNR) and the rat is placed in a rotometer. The substances are injected in a total volume of 0.2 μL over a period of 1 min. A group of animals is sacrificed by decapitation 1 hour after the injection, their brains are immediately removed and tissue samples are taken from left and right striatum, globus pallidum (GP) and substantia nigra (SN). Samples are assayed for SP and SP(1-7)[1].
Mice[2]
The accumulated response time (s) of reciprocal movements of hindlimb scratching, biting, fore- and hindpaw licking are measured in Male mice (STD strain, 23-28 g) during the whole period of aversive response and 20 min at maximum. Substance P (1-7) is tested for its ability to inhibit the aversive response produced by intrathecal injection of SP or SP(5-11) (0.1 nM/mouse). Substance P (1-7) (1, 2, 4 pmol) is then administered together with SP or SP(5-11)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20.

    [2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.

[D-Trp7,9,10]-Substance P

发表于由

[D-Trp7,9,10]-Substance P;

[D-Trp7,9,10]-Substance P 是 substance P 的类似物。Substance P 刺激 substance P 受体，但也通过烟碱乙酰胆碱受体抑制离子传导。

[D-Trp7,9,10]-Substance Pamp;;

[D-Trp7,9,10]-Substance P Chemical Structure

CAS No. : 89430-38-6

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生物活性

[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

体外研究
(In Vitro)

Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibitS the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1588.88

Formula

FH2KNP2W3
CAS 号

89430-38-6
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2
Sequence Shortening

RPKPQQWFWWM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104.

    [2]. Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243.

[D-Trp7,9,10]-Substance P TFA

发表于由

[D-Trp7,9,10]-Substance P TFA;

[D-Trp7,9,10]-Substance P TFA 是 substance P 的类似物。Substance P 刺激 substance P 受体，但也通过烟碱乙酰胆碱受体抑制离子传导。

[D-Trp7,9,10]-Substance P TFAamp;;

[D-Trp7,9,10]-Substance P TFA Chemical Structure

规格 是否有货
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生物活性

[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

体外研究
(In Vitro)

Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1702.90

Formula

C81H106F3N21O15S
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2
Sequence Shortening

RPKPQQWFWWM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104.

    [2]. Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243.

Biotin-Substance P

发表于由

Biotin-Substance P;

Biotin-Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)

Biotin-Substance Pamp;;

Biotin-Substance P Chemical Structure

CAS No. : 87468-58-4

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生物活性

Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

体外研究
(In Vitro)

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1574.90

Formula

C73H112N20O15S2
CAS 号

87468-58-4
Sequence Shortening

Biotin-RPKPQQFFGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

Substance P (7-11)

发表于由

Substance P (7-11);

Substance P (7-11) 是神经肽物质P的C-末端片段，其可引起细胞内钙浓度的增加。

Substance P (7-11)amp;;

Substance P (7-11) Chemical Structure

CAS No. : 51165-05-0

规格 价格 是否有货
5 mg ￥950 询问价格 货期
10 mg ￥1600 询问价格 货期
25 mg ￥3300 询问价格 货期

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生物活性

Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

体外研究
(In Vitro)

Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

612.78

Formula

C31H44N6O5S
CAS 号

51165-05-0
Sequence

Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

FFGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Halliday DA, et al. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 ( Pt 1):57-62.
Cell Assay
[1]

Confluent chondrocytes are incubated for 24 h with SP or Substance P (7-11). TIMP activity is inactivated following reduction and alkylation with 2 mM dithiothreitol and 5 mM iodoacetamide for 30 min at 37°C. Samples are subsequently dialysed. Latent collagenase is activated with 1 mM APt followed by inactivation with soy bean trypsin inhibitor. Collagenase is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Halliday DA, et al. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 ( Pt 1):57-62.

Substance P (1-9)

发表于由

Substance P (1-9);

Substance P (1-9) 是一种九肽，能够降低豚鼠回肠和膀胱中 substance P 的非活化程度。

Substance P (1-9)amp;;

Substance P (1-9) Chemical Structure

CAS No. : 57468-17-4

规格 价格 是否有货
1 mg ￥600 询问价格 货期
5 mg ￥1800 询问价格 货期
10 mg ￥2800 询问价格 货期

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生物活性

Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.

体外研究
(In Vitro)

Substance P (1-9) is a nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder, but with no significant effects on bradykinin or SP-(6-11)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1104.26

Formula

C52H77N15O12
CAS 号

57468-17-4
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly
Sequence Shortening

RPKPQQFFG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Growcott JW, et al. Effects of substance P-(1-9) nonapeptide amide on inactivation of substance P in vitro. Eur J Pharmacol. 1982 Oct 15;84(1-2):107-9.

[Nle11]-Substance P

发表于由

[Nle11]-Substance P;

[Nle11]-Substance P 是物质 P 类似物，避免了甲硫氨酸氧化问题。

[Nle11]-Substance Pamp;;

[Nle11]-Substance P Chemical Structure

CAS No. : 57462-42-7

规格 价格 是否有货
1 mg ￥600 询问价格 货期
5 mg ￥1800 询问价格 货期
10 mg ￥3100 询问价格 货期

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生物活性

[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

体外研究
(In Vitro)

Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1329.59

Formula

C64H100N18O13
CAS 号

57462-42-7
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-{NLE}-NH2
Sequence Shortening

RPKPQQFFGL-{NLE}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202.

[Sar9] Substance P

发表于由

[Sar9] Substance P;

[Sar9] Substance P 是一种有效的选择性神经激肽 (NK)-1 受体激动剂。

[Sar9] Substance Pamp;;

[Sar9] Substance P Chemical Structure

CAS No. : 77128-75-7

规格 是否有货
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250 mg ; 询价 ;
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生物活性

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist[1].

IC50 Target

Neurokinin (NK)-1 receptor[1]
分子量

1361.66

Formula

C64H100N18O13S
CAS 号

77128-75-7
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{SAR}-Leu-Met-NH2
Sequence Shortening

RPKPQQFF-{SAR}-LM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Lieberman DN, et al. Substance P enhances NMDA channel function in hippocampal dentate gyrus granule cells. J Neurophysiol. 1998 Jul;80(1):113-9.

Substance P(Synonyms: P物质 Neurokinin P)

发表于由

Substance P;(Synonyms: P物质; Neurokinin P) 纯度: 99.37%

Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)。

Substance Pamp;;(Synonyms: P物质; Neurokinin P)

Substance P Chemical Structure

CAS No. : 33507-63-0

规格 价格 是否有货 数量
1 mg ￥500 In-stock
5 mg ￥1100 In-stock
10 mg ￥2000 In-stock
25 mg ￥4500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Substance P 相关产品

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  • Natural Product Library Plus
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  • GPCR/G Protein Compound Library
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  • Human Endogenous Metabolite Compound Library
  • Drug Repurposing Compound Library
  • Endocrinology Compound Library
  • Neurotransmitter Receptor Compound Library
  • Food-Sourced Compound Library
  • Peptide Library

生物活性

Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1347.63

Formula

C63H98N18O13S
CAS 号

33507-63-0
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

RPKPQQFFGLM-NH2
中文名称

P物质
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 25 mg/mL (18.55 mM; Need ultrasonic)

H2O : ≥ 20 mg/mL (14.84 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7420 mL 3.7102 mL 7.4204 mL
5 mM 0.1484 mL 0.7420 mL 1.4841 mL
10 mM 0.0742 mL 0.3710 mL 0.7420 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.86 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.86 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.86 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

    [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.

Substance P TFA(Synonyms: Neurokinin P TFA)

发表于由

Substance P TFA;(Synonyms: Neurokinin P TFA) 纯度: 99.60%

Substance P TFA (Neurokinin P TFA) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)。

Substance P TFAamp;;(Synonyms: Neurokinin P TFA)

Substance P TFA Chemical Structure

CAS No. : 148470-19-3

规格 价格 是否有货 数量
1 mg ￥500 In-stock
5 mg ￥1100 In-stock
10 mg ￥2000 In-stock
25 mg ￥4500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Substance P TFA 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

IC50 Target

Neurokinin 1 receptor[1]
体外研究
(In Vitro)

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1461.67

Formula

C65H99F3N18O15S
CAS 号

148470-19-3
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

RPKPQQFFGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (68.41 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6841 mL 3.4207 mL 6.8415 mL
5 mM 0.1368 mL 0.6841 mL 1.3683 mL
10 mM 0.0684 mL 0.3421 mL 0.6841 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

    [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.