标签归档：tfa

SPR741 TFA(Synonyms: NAB741 TFA)

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SPR741 TFA;(Synonyms: NAB741 TFA)

SPR741 TFA (NAB741 TFA) 是衍生自多粘菌素 B 的阳离子肽，是一种增效剂分子。SPR741 TFA 可提高革兰氏阴性细菌外膜的通透性，用于抑制严重的革兰氏阴性细菌感染。SPR741 TFA 抑制具有多重耐药性的革兰氏阴性细菌。当与抗生素结合使用时，SPR741 TFA 具有扩展抗生素活性谱的能力。

SPR741 TFAamp;;(Synonyms: NAB741 TFA)

SPR741 TFA Chemical Structure

规格 是否有货
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SPR741 TFA 的其他形式现货产品:

SPR741 acetate

生物活性

SPR741 TFA (NAB741 TFA) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 TFA increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 TFA inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 TFA[1][2].

体外研究
(In Vitro)

SPR741 potentiates antibiotics that are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 but that potentiation of intrinsic resistance due primarily to efflux may be limited[1].
SPR741 lacks significant antibacterial activity as a stand-alone agent but interacts with the outer membrane of Gram-negative bacteria to increase permeability and thereby improve the accumulation of coadministered antibiotics inside the pathogen[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

SPR741 has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus sensitizing them to hydrophobic antibiotics. SPR741 has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. In multiday rodent and nonhuman primate studies, polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1106.15

Formula

C46H74F3N13O15
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00200-17.

    [2]. Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00892-19.

Ziconotide TFA(Synonyms: SNX-111 TFA)

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Ziconotide TFA;(Synonyms: SNX-111 TFA)

Ziconotide TFA (SNX-111 TFA) 是一种肽，是一种有效且选择性的 N 型钙通道 (N-type calcium channels) 拮抗剂阻断剂。Ziconotide TFA 减少突触传递，并可用于慢性疼痛研究。

Ziconotide TFAamp;;(Synonyms: SNX-111 TFA)

Ziconotide TFA Chemical Structure

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Ziconotide TFA 的其他形式现货产品:

Ziconotide acetate

生物活性

Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research[1].

IC50 Target[1]

N-Type Ca2+ Channel

;

体外研究
(In Vitro)

Most native cells express a variety of different calcium channels and as a result, Ziconotide TFA only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide TFA also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide TFA delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) TFA reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
Dosage: 25 pmol/site, 50 pmol/site, 100 pmol/site
Administration: Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result: Significantly reduced the mechanical hypersensitivity in animals with EAE.

Clinical Trial

分子量

3437.30

Formula

C116H179F21N36O46S7
Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2(Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
中文名称

齐考诺肽TFA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85.

    [2]. Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327.

Indolicidin TFA

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Indolicidin TFA;

Indolicidin TFA 是一种从牛中性粒细胞的细胞质颗粒中纯化的强效抗菌肽。

Indolicidin TFAamp;;

Indolicidin TFA Chemical Structure

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Indolicidin TFA 的其他形式现货产品:

Indolicidin Indolicidin acetate

生物活性

Indolicidin TFA is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils[1].

分子量

2020.31

Formula

C102H133F3N26O15
Sequence Shortening

ILPWKWPWWPWRR-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Falla TJ, et al. Mode of action of the antimicrobial peptide indolicidin. J Biol Chem. 1996;271(32):19298-19303.

    [2]. Selsted ME, et al. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J Biol Chem. 1992;267(7):4292-4295.

WKYMVM TFA

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WKYMVM TFA;

WKYMVM (TFA) 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂，同时可以激活一些白细胞效应功能，如趋化性、激活补体受体-3 及 NADPH 氧化酶。

WKYMVM TFAamp;;

WKYMVM TFA Chemical Structure

CAS No. : 1313730-09-4

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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WKYMVM TFA 的其他形式现货产品:

WKYMVM

生物活性

WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2].

IC50 Target

FPR1, FPRL1[1], FPRL2[2]
分子量

970.13

Formula

C43H62F3N9O9S2
CAS 号

1313730-09-4
Sequence

Trp-Lys-Tyr-Met-Val-Met-NH2
Sequence Shortening

WKYMV-{d-Met}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93.

    [2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.

PGLa TFA

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PGLa TFA; 纯度: 99.39%

PGLa TFA 是一种含 21 个残基的抗菌肽。PGLa TFA 是在蛙皮及其分泌物中发现的抗菌肽麦角菌素家族的成员。

PGLa TFAamp;;

PGLa TFA Chemical Structure

规格 价格 是否有货 数量
500 μg ￥1900 In-stock
1 mg ￥3400 In-stock
5 mg ￥11000 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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PGLa TFA 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

PGLa TFA, a 21-residue peptide, is an antimicrobial peptide. PGLa TFA is a member of the magainin family of antibiotic peptides found in frog skin and its secretions[1].

IC50 Target

Anti-bacteria[1]
体外研究
(In Vitro)

PGLa is a peptide starting with a glycine and ending with a leucine amide[1].
PGLa is bacteriostatic against both Gram-positive and Gram-negative bacteria with MIC values of 64 and 32 mg/L against S. aureus and E. coli, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

2082.47

Formula

C90H163F3N26O24S
Sequence

Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2
Sequence Shortening

GMASKAGAIAGKIAKVALKAL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Bechinger B, et al. Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J. 1998 Feb;74(2 Pt 1):981-7.

    [2]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27.

Epinecidin-1 TFA

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Epinecidin-1 TFA;

Epinecidin-1 TFA 是从橙斑石斑鱼 (Epinephelus coioides) 得到的的多功能抗菌肽 (AMP)。Epinecidin-1 TFA 具有抗菌、抗真菌、抗病毒、抗肿瘤和免疫调节作用。Epinecidin-1 TFA 可能成为目前抗生素的替代试剂。

Epinecidin-1 TFAamp;;

Epinecidin-1 TFA Chemical Structure

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生物活性

Epinecidin-1 TFA is a multi-functional antimicrobial peptide (AMP) from Orange-spotted grouper (Epinephelus coioides). Epinecidin-1 TFA has antibacterial, antifungal, antiviral, anti-tumor, and immunomodulatory effects. Epinecidin-1 TFA has the potential to be an alternative for current antibiotics[1].

Formula

C114H176N30O21S.xC2HF3O2
Sequence Shortening

GFIFHIIKGLFHAGKMIHGLV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alireza Neshani, et al. Epinecidin-1, a Highly Potent Marine Antimicrobial Peptide With Anticancer and Immunomodulatory Activities.BMC Pharmacol Toxicol. 2019 May 28;20(1):33.

Tyroserleutide TFA(Synonyms: 酪丝亮肽三氟乙酸盐)

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Tyroserleutide TFA;(Synonyms: 酪丝亮肽三氟乙酸盐)

Tyroserleutide TFA 可从猪脾脏的降解产物中分离得到，是一种小分子三肽，在体内外均可抑制肿瘤生长。

Tyroserleutide TFAamp;;(Synonyms: 酪丝亮肽三氟乙酸盐)

Tyroserleutide TFA Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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Tyroserleutide TFA 的其他形式现货产品:

Tyroserleutide hydrochloride

生物活性

Tyroserleutide TFA, isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2].

IC50 Target

Antitumor tripeptide[1][2]
体外研究
(In Vitro)

Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1].
Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2].
Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2].
Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1]
Dosage: 10, 20, 40, and 80 μg/kg
Administration: Injection (i.p.) one time every day until mice were dead.
Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively.

Clinical Trial

分子量

495.45

Formula

C20H28F3N3O8
中文名称

酪丝亮肽三氟乙酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Wang C, et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep Biochem Biotechnol. 2003 Aug;33(3):189-95.

    [2]. Liang P, et al. pH-Triggered Conformational Change of Antp-Based Drug Delivery Platform for Tumor Treatment with Combined Photothermal Therapy and Chemotherapy. Adv Healthc Mater. 2019 Aug;8(15):e1900306.

740 Y-P TFA(Synonyms: 740YPDGFR TFA PDGFR 740Y-P TFA)

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740 Y-P TFA;(Synonyms: 740YPDGFR TFA; PDGFR 740Y-P TFA)

740 Y-P TFA (740YPDGFR; PDGFR 740Y-P) 是一个有效的，具有细胞渗透性的 PI3K 激活剂。740 Y-P TFA 很容易结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白，但不能单独结合 GST。

740 Y-P TFAamp;;(Synonyms: 740YPDGFR TFA; PDGFR 740Y-P TFA)

740 Y-P TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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740 Y-P TFA 的其他形式现货产品:

740 Y-P

生物活性

740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1].

体外研究
(In Vitro)

740 Y-P TFA (50 μg/ml; 48 hours) specificly stimulates mitogenesis in medium is better than EGF or FGF at stimulating entry into S-phase, it shows the percentage of cells in S-phase for 48.3% in C2 cells. Additionally, LY294002 or wortmannin potently inhibits the mitogenic response stimulated by the 740 Y-P TFA peptide[1].
740 Y-P TFA (1 μg/mL) stimulates mitogenesis at the lowest concentration tested. The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 μg/mL. 740Y-P to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides[1].
740 Y-P TFA (30 μM; 24 hours) remarkably inhibits the level of LC3-II/LC3-I in GO-induced PC12 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: PC12 cells
Concentration: 30 μM
Incubation Time: 24 hours
Result: Inhibited the protein expression of LC3-II.

分子量

3384.72

Formula

C143H223N43F3O41PS3
Sequence Shortening

RQIKIWFQNRRMKWKKSDGG-{PO2Y}-MDMS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.

    [2]. Xiaoli Feng, et al. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Acta Biomater. 2018 Nov;81:278-292.

Tirzepatide TFA(Synonyms: LY3298176 TFA)

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Tirzepatide TFA;(Synonyms: LY3298176 TFA)

Tirzepatide TFA (LY3298176 TFA) 是葡萄糖依赖性胰岛素营养多肽 (GIP) 和胰高血糖素样肽-1 (GLP-1) 受体双重激动剂，有潜力用于 2 型糖尿病的研究。

Tirzepatide TFAamp;;(Synonyms: LY3298176 TFA)

Tirzepatide TFA Chemical Structure

规格 价格 是否有货
1 mg ￥5500 询问价格 货期
5 mg ￥12000 询问价格 货期

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Tirzepatide TFA 的其他形式现货产品:

Tirzepatide hydrochloride

生物活性

Tirzepatide TFA (LY3298176 TFA) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes[1].

IC50 Target

Glucose-dependent insulinotropic polypeptide (GIP), GLP-1 receptor[1]
Clinical Trial

分子量

4927.47

Formula

C???H???F?N??O??
Sequence Shortening

Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{diacid-gamma-Glu-(AEEA)2-Lys}-AFVQWLIAGGPSSGAPPPS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Frias JP, et al. Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial. Lancet. 2018 Nov 17;392(10160):2180-2193.

Brain Natriuretic Peptide-45, rat TFA(Synonyms: BNP-45, rat TFA)

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Brain Natriuretic Peptide-45, rat TFA;(Synonyms: BNP-45, rat TFA)

Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) 是一种从大鼠心脏中分离出来的大鼠脑利钠肽的循环形式，具有强大的降压和利钠功效。

Brain Natriuretic Peptide-45, rat TFAamp;;(Synonyms: BNP-45, rat TFA)

Brain Natriuretic Peptide-45, rat TFA Chemical Structure

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生物活性

Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency[1].

体内研究
(In Vivo)

Brain Natriuretic Peptide-45, rat (0.1, 0.2, 0.5, 1.0 and 2.0 nmol/kg, i.v.) shows potent natriuretic and hypotensive activities in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Brain Natriuretic Peptide-45, rat with high concentration decreases blood pressure in SHR. But WKY is more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. In addition, high dose of Brain Natriuretic Peptide-45, rat cuases prolonged lowering of blood pressure and urinary cGMP excretion in WKY[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

5154.69

Formula

C215H350N71O67F3S3
Sequence

Ser-Gln-Asp-Ser-Ala-Phe-Arg-Ile-Gln-Glu-Arg-Leu-Arg-Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Gly-Leu-Arg-Leu-Phe(Disulfide bridge: Cys23-Cys39)
Sequence Shortening

SQDSAFRIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF(Disulfide bridge: Cys23-Cys39)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kita T, et al. Effects of brain natriuretic peptide-45, a circulating form of rat brain natriuretic peptide, in spontaneously hypertensive rats. Eur J Pharmacol. 1991 Sep 4;202(1):73-9.