Theaflavin 3-Di-O-Gallate 品牌:Nagara Science


Theaflavin 3-Di-O-Gallate

品牌:Nagara Science
CAS No.:
储存条件:-20℃
纯度:>90%(HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

NH030301

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Theaflavin-3′-gallate(Synonyms: 茶黄素-3′-没食子酸酯)

天然产物 糖类和糖苷 Saccharides and Glycosides

Theaflavin-3′-gallate (Synonyms: 茶黄素-3′-没食子酸酯) 纯度: 98.68%

Theaflavin-3′-gallate 是一种红茶茶黄素单体,被认为是红茶生物学上重要的活性成分,有益健康。Theaflavin-3′-gallate 充当促氧化剂并在癌细胞中诱导氧化应激。Theaflavin-3′-gallate 可以以时间和浓度依赖性方式与还原型谷胱甘肽 (GSH) 直接反应。

Theaflavin-3

Theaflavin-3′-gallate Chemical Structure

CAS No. : 28543-07-9

规格 价格 是否有货 数量
1 mg ¥1000 In-stock
5 mg ¥2500 In-stock
10 mg ¥4200 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Theaflavin-3′-gallate 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Oxygen Sensing Compound Library
  • Phenols Library
  • Flavonoids Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food-Sourced Compound Library

生物活性

Theaflavin-3′-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3′-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3′-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner[1].

分子量

716.60

Formula

C36H28O16

CAS 号

28543-07-9

中文名称

茶黄素-3′-没食子酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (69.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3955 mL 6.9774 mL 13.9548 mL
5 mM 0.2791 mL 1.3955 mL 2.7910 mL
10 mM 0.1395 mL 0.6977 mL 1.3955 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.49 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.49 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Babich H, et al. Theaflavin-3-gallate and theaflavin-3′-gallate, polyphenols in black tea with prooxidant properties. Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):66-74.

Theaflavin 3,3′-digallate(Synonyms: 茶黄素-3,3′-双没食子酸; TF-3; ZP10)

天然产物 黄酮类 Flavonoids

Theaflavin 3,3′-digallate (Synonyms: 茶黄素-3,3′-双没食子酸; TF-3; ZP10) 纯度: 99.73%

Theaflavin 3,3′-digallate (TF-3) 是有效的寨卡病毒 (ZIKV) 蛋白酶抑制剂,IC50 为 2.3 μM。Theaflavin 3,3′-digallate 直接与 ZIKVpro 结合 (Kd=8.86 µM) 并抑制 ZIKV 复制。Theaflavin 3,3′-digallate 抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSVHIV-1 病毒活性。Theaflavin 3,3′-digallate 是红茶中的典型色素,一种有效的抗肿瘤剂。

Theaflavin 3,3

Theaflavin 3,3′-digallate Chemical Structure

CAS No. : 30462-35-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3278 In-stock
5 mg ¥2020 In-stock
10 mg ¥3430 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Theaflavin 3,3′-digallate 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antiviral Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Food-Sourced Compound Library

生物活性

Theaflavin 3,3′-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3′-digallat directly binds to ZIKVpro (Kd=8.86 µM) and inhibits ZIKV replication. Theaflavin 3,3′-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1[1]. Theaflavin 3,3′-digallate, the typical pigment in black tea, is a potent antitumor agent[2].

IC50 & Target[1]

HSV

 

HIV-1

 

体外研究
(In Vitro)

Theaflavin 3,3′-digallate (TF-3; 6.25, 12.5, 25 μM; 24 hours) markedly reduces viral RNA copy numbers and NS3, U87 MG protein expression in a dose-dependent manner[1].
Theaflavin 3,3′-digallate inhibits dose-dependently ZIKV replication in Vero E6 cells (EC50=7.65 μM). Theaflavin 3,3′-digallate has minor cytotoxicity up to 40 μM in Vero E6 cells. Theaflavin 3,3′-digallate can inhibit the post-entry events of the ZIKV replication cycle from gene transcription and translation levels[1].
Theaflavin 3,3′-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3′-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3′-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Vero E6 cells
Concentration: 6.25, 12.5, 25 μM
Incubation Time: 24 hours
Result: Markedly reduced NS3, U87 MG protein expression in a dose-dependent manner.

Clinical Trial

分子量

868.70

Formula

C43H32O20

CAS 号

30462-35-2

中文名称

茶黄素-3,3′-双没食子酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (115.11 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1511 mL 5.7557 mL 11.5115 mL
5 mM 0.2302 mL 1.1511 mL 2.3023 mL
10 mM 0.1151 mL 0.5756 mL 1.1511 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.88 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.88 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Xiangling Cui, et al. Identification of Theaflavin-3,3′-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313.

    [2]. Ding Y, et al. Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line. Food Nutr Res. 2017 Nov 15;61(1):1400340.

Theaflavin(Synonyms: 茶黄素)

天然产物 黄酮类 Flavonoids

Theaflavin (Synonyms: 茶黄素) 纯度: 99.69%

Theaflavin 是一种天然的甲型流感 (H1N1) 神经氨酸酶抑制剂。

Theaflavin(Synonyms: 茶黄素)

Theaflavin Chemical Structure

CAS No. : 4670-05-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1860 In-stock
2 mg ¥800 In-stock
5 mg ¥1500 In-stock
10 mg ¥2000 In-stock
25 mg ¥4500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Theaflavin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Antiviral Compound Library
  • Human Endogenous Metabolite Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Food-Sourced Compound Library

生物活性

Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Theaflavin, found in green tea, is observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Theaflavin is a plant product traditionally used for treatment of influenza infection. Green tea is particularly rich in polyphenolic compounds like Theaflavin. Theaflavin derivatives have shown pronounced antiviral activity. Theaflavin is found to interact with the amino acid residues like Arg118, Asp151, Asp 152, Arg193, Asp199, Asn344, and Arg430 of NA by forming hydrogen bonds[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

564.49

Formula

C29H24O12

CAS 号

4670-05-7

中文名称

茶黄素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (221.44 mM; Need ultrasonic)

H2O : 2 mg/mL (3.54 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7715 mL 8.8576 mL 17.7151 mL
5 mM 0.3543 mL 1.7715 mL 3.5430 mL
10 mM 0.1772 mL 0.8858 mL 1.7715 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (11.07 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (11.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (11.07 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (11.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Sahoo M, et al. Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking. Genomics Inform. 2016 Sep;14(3):96-103.

Theaflavin-3-gallate(Synonyms: 茶黄素-3-没食子酸酯)

天然产物 黄酮类 Flavonoids

Theaflavin-3-gallate (Synonyms: 茶黄素-3-没食子酸酯) 纯度: 98.24%

Theaflavin-3-gallate 是一种红茶茶黄素单体,被认为是红茶生物学上重要的活性成分,有益健康。Theaflavin-3-gallate 充当促氧化剂并在癌细胞中诱导氧化应激。Theaflavin-3-gallate 可以以时间和浓度依赖性方式与还原型谷胱甘肽 (GSH) 直接反应。

Theaflavin-3-gallate(Synonyms: 茶黄素-3-没食子酸酯)

Theaflavin-3-gallate Chemical Structure

CAS No. : 30462-34-1

规格 价格 是否有货 数量
5 mg ¥4030 In-stock
10 mg ¥6860 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Theaflavin-3-gallate 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Oxygen Sensing Compound Library
  • Phenols Library
  • Flavonoids Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food-Sourced Compound Library

生物活性

Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner[1].

分子量

716.60

Formula

C36H28O16

CAS 号

30462-34-1

中文名称

茶黄素-3-没食子酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (69.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3955 mL 6.9774 mL 13.9548 mL
5 mM 0.2791 mL 1.3955 mL 2.7910 mL
10 mM 0.1395 mL 0.6977 mL 1.3955 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.49 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.49 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Babich H, et al. Theaflavin-3-gallate and theaflavin-3′-gallate, polyphenols in black tea with prooxidant properties. Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):66-74.