Thymus peptide C is a hormonal drug derived from the thymus glands of young calves, which works as a substitute for the physiological functions of the thymus.
体外研究 (In Vitro)
Thymus Peptide C antagonizes the adrenocortical hormones’ effect on the lymphatic system. Thymus Peptide C works as a substitute for the physiological functions of the thymus. With T-cell deficiency, Thymus Peptide C recruits immature system cells in the bone marrow and stimulates their maturation to the fully active T-cell phase in the lymphatic system. Thymus Peptide C increases granulopoiesis and erythropoiesis by acting on the bone marrow. The preparation can be used for all diseases with primary and secondary immune system disturbances involving T-cells which are thymus dependent and for a wide range of symptoms such as chronic viral, bacterial and fungal infections; allergic and auto-immune reactions; and certain lymphoproliferative syndromes.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
316791-23-8
运输条件
Room temperature in continental US; may vary elsewhere.
Thymic factor X (TFX-Jelfa) 是一种来自幼年小牛胸腺的水提取物，也是一种天然的淋巴细胞功能刺激剂。
Thymus factor X Chemical Structure
CAS No. : 78310-77-7
规格
价格
是否有货
数量
1 mg
￥1800
In-stock
5 mg
￥7200
In-stock
10 mg
;
询价
;
50 mg
;
询价
;
* Please select Quantity before adding items.
Thymus factor X 相关产品
bull;相关化合物库:
Bioactive Compound Library Plus
Peptide Library
生物活性
Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function[1][2].
体内研究 (In Vivo)
The percentage of necrotic lymphocytes in the spleen in Group I (infected with T. spiralis and treated with Thymus factor X (TFX)) is significantly lower than in the control group on day 7, and approximately the same as in the control group for the rest of the experiment. The percentage of necrotic lymphocytes in muscle tissue in Group I is approximately the same as in the control group on day 7, significantly lower on days 14 and 21 (p<0.0002), approximately the same on days 28 and 35, significantly lower on day 42, and significantly higher on day 60 (p<0.005)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
78310-77-7
中文名称
胸腺因子X
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-80deg;C
2 years
-20deg;C
1 year
In solvent
-80deg;C
6 months
-20deg;C
1 month
Solvent Solubility
In Vitro:;
H2O
Peptide Solubility and Storage Guidelines:
1.;;Calculate the length of the peptide.
2.;;Calculate the overall charge of the entire peptide according to the following table:
;
Contents
Assign value
Acidic amino acid
Asp (D), Glu (E), and the C-terminal -COOH.
-1
Basic amino acid
Arg (R), Lys (K), His (H), and the N-terminal -NH2
+1
Neutral amino acid
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)
0
3.;;Recommended solution:
Overall charge of peptide
Details
Negative (lt;0)
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH4OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)
1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
[1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33.
[2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.
Animal Administration [1]
The experiment is carried out using 134 mice divided into three groups: Group I: 46 mice infected with T. spiralis and treated with Thymus factor X (TFX); Group II: 42 uninfected mice treated with Thymus factor X; and Control group: 46 mice infected with T. spiralis and not treated with Thymus factor X. Thymus factor X is administered subcutaneously at a dose of 15 mg/kg. The first dose is administered on the third day before the mice are infected with T. spiralis. The dose is repeated at 24 h intervals until the thirteenth day after infection. In all, 17 doses are administered. On days 7, 14, 21, 28, 35, 42, and 60 after infection, six mice from each group are sacrificed using halothane. The spleen, mesenteric lymph nodes and masseter muscles are excised from each mouse and transferred to sterile phospho-buffered saline at 4°C[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33.
[2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.
