TNF-α (10-36), human

TNF-α (10-36), human;

TNF-α (10-36), human 是人 TNF-α 的多肽片段。

TNF-α (10-36), humanamp;;

TNF-α (10-36), human Chemical Structure

CAS No. : 144796-70-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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TNF-alpha; (10-36), human 的其他形式现货产品:

TNF-alpha; (10-36), human TFA

生物活性

TNF-α (10-36), human is a peptide of human TNF-α.

分子量

2996.34

Formula

C131H211N43O38

CAS 号

144796-70-3

Sequence Shortening

DKPVAHVVANPQAEGQLQWLNRRANAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

TNF-α (46-65), human

TNF-α (46-65), human;

TNF-α (46-65), human 是 TNF-α 的多肽片段。

TNF-α (46-65), humanamp;;

TNF-α (46-65), human Chemical Structure

CAS No. : 144796-72-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

TNF-α (46-65), human is a peptide of TNF-α.

分子量

2310.69

Formula

C110H172N24O30

CAS 号

144796-72-5

Sequence

Asn-Gln-Leu-Val-Val-Pro-Ser-Glu-Gly-Leu-Tyr-Leu-Ile-Tyr-Ser-Gln-Val-Leu-Phe-Lys

Sequence Shortening

NQLVVPSEGLYLIYSQVLFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

TNF-α (46-65), human TFA

TNF-α (46-65), human TFA;

TNF-α (46-65), human (TFA) 是人 TNF-α 的多肽片段。

TNF-α (46-65), human TFAamp;;

TNF-α (46-65), human TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

TNF-α (46-65), human (TFA) is a peptide of human TNF-α.

分子量

2424.71

Formula

C112H173F3N24O32

Sequence

Asn-Gln-Leu-Val-Val-Pro-Ser-Glu-Gly-Leu-Tyr-Leu-Ile-Tyr-Ser-Gln-Val-Leu-Phe-Lys

Sequence Shortening

NQLVVPSEGLYLIYSQVLFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Infliximab(Synonyms: Avakine CT-P13)

Infliximab;(Synonyms: Avakine; CT-P13) 纯度: 90.30%

Infliximab (Avakine) 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。Infliximab 可阻止 TNF-α 与 TNF-α 受体 1 (TNFR1) 和 TNFR2 的相互作用。Infliximab 可用于自身免疫,慢性炎症性疾病和糖尿病神经病变的研究。

Infliximabamp;;(Synonyms: Avakine;  CT-P13)

Infliximab Chemical Structure

CAS No. : 170277-31-3

规格 价格 是否有货 数量
1 mg ¥1200 In-stock
5 mg ¥3000 In-stock
25 mg ¥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research[1][2].

IC50 Target[1]

TNF-α

;

体外研究
(In Vitro)

TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α+/+) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

CAS 号

170277-31-3

中文名称

英夫利昔单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lucia A Méndez-García, et al. Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro. Scand J Immunol. 2018 Nov;88(5):e12716.

    [2]. Isamu Yamakawa, et al. Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E844-52.

β-Anhydroicaritin

天然产物 黄酮类 Flavonoids

β-Anhydroicaritin  纯度: 98.43%

β-Anhydroicaritin 提取自 Boswellia carterii Birdware,具有重要的生物学和药理学作用,例如抗骨质疏松症,雌激素调节和抗肿瘤特性。β-Anhydroicaritin 改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。β-Anhydroicaritin 减少腹膜炎小鼠 NO,IL-10,TNF-α,MCP-1 和 IL-6 的过量产生。β-Anhydroicaritin 抑制细胞内 Ca2+ 的升高,并显着降低 iNOS 蛋白的表达。

β-Anhydroicaritin

β-Anhydroicaritin Chemical Structure

CAS No. : 38226-86-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥660 In-stock
5 mg ¥600 In-stock
10 mg ¥1000 In-stock
20 mg ¥1800 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

β-Anhydroicaritin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Differentiation Inducing Compound Library
  • Diabetes Related Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Anti-Pancreatic Cancer Compound Library
  • Angiogenesis Related Compound Library

生物活性

β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].

IC50 & Target[1][2][3]

IL-10

 

IL-6

 

TNF-α

 

MMP-3

 

分子量

368.38

Formula

C21H20O6

CAS 号

38226-86-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL (22.61 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7146 mL 13.5729 mL 27.1459 mL
5 mM 0.5429 mL 2.7146 mL 5.4292 mL
10 mM 0.2715 mL 1.3573 mL 2.7146 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Nguyen VS, et al. Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines. Anticancer Agents Med Chem. 2017;17(1):137-142

    [2]. Wu Y, et al. Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats. Mol Med Rep. 2015 Aug;12(2):1829-37.

    [3]. Lai X, et al. Protective effect of anhydroicaritin against peritonitis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Oct;29(10):1036-9.

TNF-α (31-45), human TFA

TNF-α (31-45), human TFA; 纯度: 98.06%

TNF-α (31-45), human (TFA) 是人肿瘤坏死因子-α 的多肽片段。

TNF-α (31-45), human TFAamp;;

TNF-α (31-45), human TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ¥3500 In-stock
10 mg ¥5500 In-stock
50 mg ¥16500 In-stock
100 mg ¥25500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

TNF-alpha; (31-45), human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.

分子量

1781.89

Formula

C71H123F3N26O24

Sequence

Arg-Arg-Ala-Asn-Ala-Leu-Leu-Ala-Asn-Gly-Val-Glu-Leu-Arg-Asp

Sequence Shortening

RRANALLANGVELRD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

H2O : 33.33 mg/mL (18.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5612 mL 2.8060 mL 5.6120 mL
5 mM 0.1122 mL 0.5612 mL 1.1224 mL
10 mM 0.0561 mL 0.2806 mL 0.5612 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

TNF-α (10-36), human TFA

TNF-α (10-36), human TFA; 纯度: 97.70%

TNF-α (10-36), human (TFA) 是人 TNF-α 的多肽片段。

TNF-α (10-36), human TFAamp;;

TNF-α (10-36), human TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥1600 In-stock
5 mg ¥4000 In-stock
10 mg ¥6800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

TNF-alpha; (10-36), human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

TNF-α (10-36), human (TFA) is a peptide of human TNF-α.

分子量

3110.36

Formula

C133H212N43O40

Sequence Shortening

DKPVAHVVANPQAEGQLQWLNRRANAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.