TRAP-6 amide

TRAP-6 amide;

TRAP-6 amide 是一个 PAR-1 凝血酶受体的肽类激动剂。

TRAP-6 amideamp;;

TRAP-6 amide Chemical Structure

CAS No. : 141923-40-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide[1].

分子量

748.87

Formula

C34H56N10O9

CAS 号

141923-40-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sofia Ramström, et al. Platelet Phosphatidylserine Exposure and Procoagulant Activity in Clotting Whole Blood–Different Effects of Collagen, TRAP and Calcium Ionophore A23187. Thromb Haemost. 2003 Jan;89(1):132-41.

Scrambled TRAP Fragment

Scrambled TRAP Fragment;

Scrambled TRAP Fragment 是 TRAP Fragment的杂乱序列。Scrambled TRAP Fragment 与 TRAP Fragment 活性片段具有相同的氨基酸组成,但排列顺序是随机打乱的。 Scrambled TRAP Fragment 常用作阴性对照。

Scrambled TRAP Fragmentamp;;

Scrambled TRAP Fragment Chemical Structure

CAS No. : 1348418-97-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Scrambled TRAP Fragment is a scrambled sequence of TRAP Fragment. Scrambled TRAP Fragment with a random sequence of the amino acids that are the same as the active fragment. Scrambled TRAP Fragment usually used as a negative control.

分子量

747.89

Formula

C34H57N11O8

CAS 号

1348418-97-2

Sequence

Phe-Ser-Leu-Leu-Arg-Asn-NH2

Sequence Shortening

FSLLRN-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

TRAP-6 amide TFA

TRAP-6 amide TFA;

TRAP-6 amide TFA 是一个 PAR-1 凝血酶受体的肽类激动剂。

TRAP-6 amide TFAamp;;

TRAP-6 amide TFA Chemical Structure

CAS No. : 1426807-16-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide[1].

分子量

862.89

Formula

C36H57F3N10O11

CAS 号

1426807-16-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Sofia Ramström, et al. Platelet Phosphatidylserine Exposure and Procoagulant Activity in Clotting Whole Blood–Different Effects of Collagen, TRAP and Calcium Ionophore A23187. Thromb Haemost. 2003 Jan;89(1):132-41.

TRAP-6(Synonyms: PAR-1 agonist peptide Thrombin Receptor Activator Peptide 6)

TRAP-6;(Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6) 纯度: 99.74%

TRAP-6 (PAR-1 agonist peptide),一种多肽片段,是选择性的蛋白酶激活受体 1 (PAR1) 激动剂。TRAP-6 通过凝血酶受体激活人血小板。TRAP-6 对 PAR4 无活性。

TRAP-6amp;;(Synonyms: PAR-1 agonist peptide;  Thrombin Receptor Activator Peptide 6)

TRAP-6 Chemical Structure

CAS No. : 141136-83-6

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ¥1760 In-stock
10 mg ¥1600 In-stock
25 mg ¥3520 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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TRAP-6 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Immunology/Inflammation Compound Library
  • Peptidomimetic Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

IC50 Target

PAR1[1]

体外研究
(In Vitro)

TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].
TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

748.87

Formula

C34H56N10O9

CAS 号

141136-83-6

Sequence

Ser-Phe-Leu-Leu-Arg-Asn

Sequence Shortening

SFLLRN

中文名称

凝血酶受体激活肽6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (133.53 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3353 mL 6.6767 mL 13.3535 mL
5 mM 0.2671 mL 1.3353 mL 2.6707 mL
10 mM 0.1335 mL 0.6677 mL 1.3353 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87.

    [2]. Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6.

    [3]. Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349(2-3):237-43.