Trp7-NF1 品牌:Anygen


Trp7-NF1

品牌:Anygen
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

307-91551

0.5 mg 咨询


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[D-Trp34]-Neuropeptide Y TFA

[D-Trp34]-Neuropeptide Y TFA;

[D-Trp34]-Neuropeptide Y TFA 是有效的,选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y TFA 在 NPY Y1,Y2,Y4 和 y6 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y TFA 明显增加大鼠的食物摄入量。

[D-Trp34]-Neuropeptide Y TFAamp;;

[D-Trp34]-Neuropeptide Y TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats[1][2].

IC50 Target[1]

NPY Y5 receptor

;

体外研究
(In Vitro)

[D-Trp34]-Neuropeptide Y TFA has pKi values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5 in CHO cells. [D-Trp34]-Neuropeptide Y TFA has pEC50 values of 6.44, <6, 6.28,7.82 for rY1, rY2 in CHO cells and rY4, rY5 in HEK-293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

[D-Trp34]-Neuropeptide Y TFA (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2466.76

Formula

C112H171F3N34O26

Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9.

    [2]. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4.

[D-Pro2,D-Trp7,9]-Substance P 品牌:Peptide


[D-Pro2,D-Trp7,9]-Substance P

品牌:Peptide
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

330-41131

0.5mg 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Ac-Trp-Leu-Ala-AMC 品牌:Adipogen


Ac-Trp-Leu-Ala-AMC

品牌:Adipogen
CAS No.:1104011-59-7
储存条件:-20°C
纯度:>98% (HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-CP3-0035-M001

1 mg 600.00


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Ac-Trp-Leu-Ala-AMC 品牌:Adipogen


Ac-Trp-Leu-Ala-AMC

品牌:Adipogen
CAS No.:1104011-59-7
储存条件:-20°C
纯度:>98% (HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-CP3-0035-M005

5 mg 2,400.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH;

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 936707-21-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

667.75

Formula

C38H41N3O8

CAS 号

936707-21-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Ac-Trp-Leu-Ala-AMC [Ac-WLA-AMC] Ac-色氨酸-亮氨酸-丙氨酸-AMC [Z-WLA-AMC] 品牌:South Bay


Ac-Trp-Leu-Ala-AMC [Ac-WLA-AMC]

Ac-色氨酸-亮氨酸-丙氨酸-AMC [Z-WLA-AMC]

品牌:South Bay
CAS No.:1104011-59-7
储存条件:-20°C
纯度:>95% (HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

SBB-PS0008-M002

2 mg 2,310.00


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[D-Trp7,9,10]-Substance P

[D-Trp7,9,10]-Substance P;

[D-Trp7,9,10]-Substance P 是 substance P 的类似物。Substance P 刺激 substance P 受体,但也通过烟碱乙酰胆碱受体抑制离子传导。

[D-Trp7,9,10]-Substance Pamp;;

[D-Trp7,9,10]-Substance P Chemical Structure

CAS No. : 89430-38-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

体外研究
(In Vitro)

Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibitS the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1588.88

Formula

FH2KNP2W3

CAS 号

89430-38-6

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2

Sequence Shortening

RPKPQQWFWWM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104.

    [2]. Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243.

Ac-Ala-Asn-Trp-AMC 品牌:Adipogen


Ac-Ala-Asn-Trp-AMC

品牌:Adipogen
CAS No.:
储存条件:-20°C
纯度:>97%
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-CP3-0037-M001

1 mg 600.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Ac-Ala-Asn-Trp-AMC 品牌:Adipogen


Ac-Ala-Asn-Trp-AMC

品牌:Adipogen
CAS No.:
储存条件:-20°C
纯度:>97%
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-CP3-0037-M005

5 mg 1,200.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。