标签归档：vivit

11R-VIVIT TFA

发表于由

11R-VIVIT TFA; 纯度: 98.97%

11R-VIVIT TFA 是一种活化 T 细胞的细胞通透性核因子 (NFAT) 抑制剂。11R-VIVIT TFA 可用于足细胞和糖尿病肾病的研究。

11R-VIVIT TFAamp;;

11R-VIVIT TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥600 In-stock
5 mg ￥2200 In-stock
10 mg ￥3500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy[1].

IC50 Target

NFAT[1]
体外研究
(In Vitro)

11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3573.15

Formula

C147H259N67O36S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (27.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2799 mL 1.3993 mL 2.7987 mL
5 mM 0.0560 mL 0.2799 mL 0.5597 mL
10 mM 0.0280 mL 0.1399 mL 0.2799 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhang L, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170(2):426-439.

11R-VIVIT

发表于由

11R-VIVIT;

11R-VIVIT 是一种活化 T 细胞的细胞通透性核因子 (NFAT) 抑制剂。11R-VIVIT 可用于足细胞和糖尿病肾病的研究。

11R-VIVITamp;;

11R-VIVIT Chemical Structure

CAS No. : 592517-80-1

规格 是否有货
1 mg 询价

* Please select Quantity before adding items.

生物活性

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy[1].

IC50 Target

NFAT[1]
体外研究
(In Vitro)

11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3573.15

Formula

C147H259N67O36S
CAS 号

592517-80-1
Sequence Shortening

RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang L, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170(2):426-439.