Waltonitone(Synonyms: 长梗秦艽酮)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Waltonitone (Synonyms: 长梗秦艽酮)

Waltonitone 是一种从植物天竺葵中提取的乌斯烷型五环三萜。Waltonitone 在体外和体内均显着抑制肝癌细胞的生长并诱导细胞凋亡

Waltonitone(Synonyms: 长梗秦艽酮)

Waltonitone Chemical Structure

CAS No. : 1252676-55-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo[1].

体外研究
(In Vitro)

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells[1].
Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis[1].
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

440.70

Formula

C30H48O2

CAS 号

1252676-55-3

中文名称

长梗秦艽酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhang Z, et al. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.Cancer Lett. 2009 Dec 28;286(2):223-31.