标签归档：yap

YAP-TEAD-IN-1

发表于由

YAP-TEAD-IN-1;

YAP-TEAD-IN-1 是 YAP–TEAD 相互作用的有效的竞争性肽类抑制剂 (IC50=25 nM)。YAP-TEAD-IN-1 是一种 17mer 的多肽，与 YAP (50-171) (Kd=40 nM) 相比，其与 TEAD1 的结合亲和力更高 (Kd=15 nM)。

YAP-TEAD-IN-1amp;;

YAP-TEAD-IN-1 Chemical Structure

CAS No. : 1659305-78-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

YAP-TEAD-IN-1 的其他形式现货产品:

YAP-TEAD-IN-1 TFA

生物活性

YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].

IC50 Target

IC50: 25 nM (YAP–TEAD interaction)[1]
体外研究
(In Vitro)

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2019.86

Formula

C93H144ClN23O21S2
CAS 号

1659305-78-8
Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.

YAP-TEAD-IN-1 TFA

发表于由

YAP-TEAD-IN-1 TFA; 纯度: 99.88%

YAP-TEAD-IN-1 TFA 是 YAP-TEAD 相互作用的有效的竞争性肽类抑制剂 (IC50=25 nM)。YAP-TEAD-IN-1 TFA 是一种 17mer 的多肽，与 YAP (50-171) (Kd=40 nM) 相比，其与 TEAD1 的结合亲和力更高 (Kd= 15 nM)。

YAP-TEAD-IN-1 TFAamp;;

YAP-TEAD-IN-1 TFA Chemical Structure

CAS No. : 1659305-79-9

规格 价格 是否有货 数量
1 mg ￥1800 In-stock
5 mg ￥4200 In-stock
10 mg ￥7000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

YAP-TEAD-IN-1 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].

IC50 Target

IC50: 25 nM (YAP-TEAD interaction)[1]
体外研究
(In Vitro)

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD(1209-426) in a GST pull-down assay, the Kd of His-YAP(1209-426) is determined to be 40 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula

C93H144ClN23O21S2.xC2HF3O2
CAS 号

1659305-79-9
Sequence

Ac-Val-Pro-{Phe(3-Cl)}-{Hcy}-Leu-Arg-Lys-{Nle}-Pro-Ala-Ser-Phe-Cys-Lys-Pro-Pro-Glu-NH2 (Disulfide bridge:Hcy4-Cys13)
Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL

* “≥” means soluble, but saturation unknown.
参考文献

  • [1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.