标签归档：zip

ZIP

发表于由

ZIP; 纯度: 99.62%

ZIP 是一种选择性的 PKMζ 肽抑制剂。 ZIP 可以阻止吗啡条件性位置偏爱诱导的损伤。

ZIPamp;;

ZIP Chemical Structure

CAS No. : 863987-12-6

规格 价格 是否有货 数量
1 mg ￥1120 In-stock
5 mg ￥3850 In-stock
10 mg ￥5800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

ZIP 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

ZIP is a selective peptide inhibitor of PKMζ. ZIP injections can block the impairment in morphine conditioned place preference induced[1].

IC50 Target

PKMζ[1]
Clinical Trial

分子量

1928.38

Formula

C90H154N30O17
CAS 号

863987-12-6
Sequence Shortening

{Myr-Ser}-IYRRGARRWRKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Li Y, et, al. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31(14):5436-46.

ZIP(Scrambled)

发表于由

ZIP(Scrambled);

ZIP(Scrambled) 是一种杂乱肽，可用作 zeta 抑制肽 (ZIP) 的阴性对照。

ZIP(Scrambled)amp;;

ZIP(Scrambled) Chemical Structure

CAS No. : 908012-18-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

ZIP(Scrambled) is a scrambled control peptide for zeta inhibitory peptide (ZIP)[1].

分子量

1928.40

Formula

C90H154N30O17
CAS 号

908012-18-0
Sequence Shortening

Myristoyl-RLYRKRIWRSAGR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Peng Penny Gao, et al. Persistent Increases of PKMζ in Sensorimotor Cortex Maintain Procedural Long-Term Memory Storage. iScience. 2018 Jul 27;5:90-98.

ZIP TFA

发表于由

ZIP TFA;

ZIP TFA 是一种选择性的 PKMζ 肽抑制剂。 ZIP TFA 可以阻止吗啡条件性位置偏爱诱导的损伤。

ZIP TFAamp;;

ZIP TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

ZIP TFA 的其他形式现货产品:

ZIP

生物活性

ZIP TFA is a selective peptide inhibitor of PKMζ. ZIP TFA injections can block the impairment in morphine conditioned place preference induced[1].

IC50 Target

PKMζ[1]
Clinical Trial

分子量

2042.40

Formula

C92H155F3N30O19
Sequence Shortening

{Myr-Ser}-IYRRGARRWRKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Li Y, et, al. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31(14):5436-46.

ZIP(Scrambled) TFA

发表于由

ZIP(Scrambled) TFA;

ZIP(Scrambled) TFA 是一种杂乱肽，可用作 zeta 抑制肽 (ZIP) 的阴性对照。

ZIP(Scrambled) TFAamp;;

ZIP(Scrambled) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

ZIP(Scrambled) TFA is a scrambled control peptide for zeta inhibitory peptide (ZIP)[1].

分子量

2042.42

Formula

C92H155F3N30O19
Sequence Shortening

Myristoyl-RLYRKRIWRSAGR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Peng Penny Gao, et al. Persistent Increases of PKMζ in Sensorimotor Cortex Maintain Procedural Long-Term Memory Storage. iScience. 2018 Jul 27;5:90-98.

ZTSCXS096-Millipore密理博Zip Zip层析柱

发表于由
  • 型号 ZTSCXS096
  • 品牌 Merck Millipore密理博
  • 【简单介绍】

    Millipore密理博Zip Zip层析柱ZipTip吸管尖以可重复和高回收的方式浓缩、纯化飞（母托）摩尔级至皮（可）摩尔级的多肽、蛋白质或寡核苷酸，改善了数据的质量。为了简化分析，还可以采用分步洗脱对复杂的多肽混合物进行分馏。由于ZipTip吸管尖是样品制备的快速实用装置，大大节约操作时间，几乎可以省掉层析技术中zui费精力的分离纯化难题。
    Millipore密理博ZipTip微量层析柱 吸管

    Millipore密理博Zip Zip层析柱

     

    量层析柱Zip Tip C18

    Millipore密理博ZipTip微量层析柱 吸管 C18, 96 pk
    ZipTip微量层析柱 
    ZipTip吸管尖是一种末端带有约0.6微升层析介质的10微升吸管尖，不会出现死体积。它是质谱分析，HPLC，毛细管电泳和其他分析技术之前快速（数秒）浓缩、脱盐和分馏多肽、蛋白质或寡核苷酸的理想工具。
    微量样品制备使用的吸管尖ZipTip
    带有C18、C4或金属螯合树脂的新型10微升级的ZipTip吸管尖，是为质谱分析前浓缩和纯化1至100微升生物样品而开发的。
    ZipTip是一种末端带有约0.6μL层析介质的10μL吸管尖，因此不会出现死体积。它是质谱分析、HPLC、毛细管电泳和其它分析技术之前快速（数秒种）浓缩、脱盐和分馏多肽、蛋白质或寡核苷酸的理想工具。
    这种装置结构简单，使用方便。使用时，将其置于一个单管或多管的移液器、标准的22格钝端的HPLC针、或自动的液体操作/样品制备的工作站上。为了吸附样品，通过介质反复抽、吸几次。此时，污染物也以同样的方式被清洗掉。然后将浓缩、纯化后的样品用1-4μL相容的溶剂精确地洗脱，直接转移到质谱仪或小瓶中。对于那些要求较小洗脱量的应用（例如小于1μL），可用仅含0.2μL介质的微量规格。
    ZipTip吸管尖以可重复和高回收的方式浓缩、纯化飞（母托）摩尔级至皮（可）摩尔级的多肽、蛋白质或寡核苷酸，改善了数据的质量。为了简化分析，还可以采用分步洗脱对复杂的多肽混合物进行分馏。由于ZipTip吸管尖是样品制备的快速实用装置，大大节约操作时间，几乎可以省掉层析技术中zui费精力的分离纯化难题。
    Millipore密理博ZipTip微量层析柱 吸管 C18, 96 pk
    应用
    l 可浓缩1μL多肽、蛋白质或寡核苷酸。
    l 可清除盐、洗涤剂和离液剂。
    l 可分步洗脱多肽和蛋白质。
    l 可选择性地亲和捕获生物分子。
    其它信息

    l MALDI – TOF质谱分析前的多肽和蛋白质样品制备；
    l 电喷射/微喷射（Electospay/Nanospay）质谱分析前的多肽和蛋白质样品制备；
    l 简化质谱的多肽和蛋白质分馏；
    l MALDI – TOF质谱分析前寡核苷酸的脱盐；
    l 选择性亲和捕获生物分子。
    ZTSCXS008,ZTSCXS096，ZTSCXS024,ZTSCXS096,ZT0MCS008,ZT0MCS096
    密理博微量层析柱Zip Tip C18

    Millipore密理博Zip Zip层析柱