标签归档：zuonin

(-)-Zuonin A(Synonyms: D-Epigalbacin)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

(-)-Zuonin A (Synonyms: D-Epigalbacin) 纯度: 99.84%

(-)-Zuonin A (D-Epigalbacin) 是一种天然木质素，是有效的、选择性的 JNKs 抑制剂，对 JNK1、JNK2 和 JNK3 作用的 IC50 值分别为 1.7 μM, 2.9 μM 和 1.74 μM。

(-)-Zuonin A(Synonyms: D-Epigalbacin)

(-)-Zuonin A Chemical Structure

CAS No. : 84709-25-1

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生物活性

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].

IC50 & Target[1]

JNK1

1.7 μM (IC50)

JNK2

2.9 μM (IC50)

JNK3

1.74 μM (IC50)

体外研究
(In Vitro)

(−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].
(−)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.37

Formula

C20H20O5
CAS 号

84709-25-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (−)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883.