Astressin; 纯度: 96.91%
Astressin是有效的促肾上腺皮质激素释放因子 (CRF) 拮抗剂。
Astressin Chemical Structure
CAS No. : 170809-51-5
规格 | 价格 | 是否有货 | 数量 |
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500 μg | ¥2200 | In-stock | |
1 mg | ¥3600 | In-stock | |
5 mg | ¥14500 | In-stock | |
10 mg | ; | 询价 | ; |
50 mg | ; | 询价 | ; |
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Astressin 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
Astressin is a potent corticotropin releasing factor (CRF) antagonist. |
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体外研究 (In Vitro) |
Astressin has low affinity for the CRF binding protein and high affinity (Ki=2 nM) for the cloned pituitary receptor. Astressin shows high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Astressin is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin (ACTH) secretion in stressed or adrenalectomized rats. Low doses of astressin (30 μg and 100 μg per kg) administered i.v. still produce a significant decrease in ACTH levels at 45 and 90 min, respectively[1]. Astressin significantly reverses the anxiogenic-like response induced by both social stress and ICV rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment[2]. Intracerebroventricular infusion of the peptide both 30 min before and 10 min after seizures decreases damage in some hippocampal cell fields by as much as 84%, a magnitude of protection greater than reported for other CRF antagonists against other models of necrotic neuronal injury. Astressin protects even if administered only 10 min following excitotoxin exposure[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
3563.16 |
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Formula |
C161H269N49O42 |
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CAS 号 |
170809-51-5 |
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Sequence |
{d-Phe}-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-NLE-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-NLE-Glu-Ile-Ile-NH2 |
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Sequence Shortening |
{d-Phe}-HLLREVLE-NLE-ARAEQLAQEAHKNRKL-NLE-EII-NH2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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Animal Administration [1] |
Rats: Rat diet is supplemented with oranges, and their water contained 0.9% NaCl. They are equipped with indwelling jugular cannulae 48 h prior to the i.v. injection of either vehicle or astressin. Astressin is first diluted in sterile, distilled, apyrogenic water, and the pH is adjusted to 7.0. Further dilutions are made in 0.04 M phosphate buffer, pH 7.4, containing 0.1% bovine serum albumin and 0.01% ascorbic acid. Blood samples are obtained immediately before treatment, as well as 15-120 min later. Decanted plasma samples are frozen until assayed for ACTH concentrations[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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