Luciferase(Synonyms: 荧光素酶)

Luciferase;(Synonyms: 荧光素酶)

Luciferase,来自Vibrio fischeri,可用于评估生物发光细菌的光发射和氧消耗动力学。

Luciferase (Synonyms: 荧光素酶)

Luciferase Chemical Structure

CAS No. : 9014-00-0

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生物活性

Luciferase from Vibrio fischeri has also been used in a study to investigate the sensitivity of dark mutants of various strains of luminescent bacteria to reactive oxygen species.

CAS 号

9014-00-0

中文名称

荧光素酶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (Need ultrasonic)

Caesappanin C

天然产物 天然产物苯丙素类 Phenylpropanoids

Caesappanin C 

Caesappanin C 是一种来自印度尼西亚 Caesalpinia sappan L. 心材的乙醇提取物的联苯二聚体,在体外显示出对原代成骨细胞的强增殖刺激活性。 Caesappanin C 具有刺激骨形成和再生的潜力。

Caesappanin C

Caesappanin C Chemical Structure

CAS No. : 1913319-59-1

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生物活性

Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration[1].

分子量

608.59

Formula

C32H32O12

CAS 号

1913319-59-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Subehan, et al. Phytochemical investigation of the active constituents from Caesalpinia sappan on stimulation of osteoblastic cells. Plant Biotechnology, 2014,31(5), 505–509.

Bayogenin(Synonyms: 贝萼皂苷元)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Bayogenin (Synonyms: 贝萼皂苷元)

Bayogenin 是一种紫花苜蓿皂苷,具有一定的糖原磷酸化酶抑制作用。

Bayogenin(Synonyms: 贝萼皂苷元)

Bayogenin Chemical Structure

CAS No. : 6989-24-8

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生物活性

Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition[1][2].

分子量

488.70

Formula

C30H48O5

CAS 号

6989-24-8

中文名称

贝萼皂苷元

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Kiełbasa A, et al. Isolation and determination of saponin hydrolysis products from Medicago sativa using supercritical fluid extraction, solid-phase extraction and liquid chromatography with evaporative light scattering detection. J Sep Sci. 2019 Jan;42(2):465-474.

    [2]. Xiao-AnWEN, et al. Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4-Epi-hederagonic Acid as Glycogen Phosphorylase Inhibitors. Chinese Journal of Natural Medicines. 2010 Nov;8(6): 441-448.

Narcissin(Synonyms: 水仙苷; Narcissoside)

天然产物 黄酮类 Flavonoids

Narcissin (Synonyms: 水仙苷; Narcissoside) 纯度: 99.72%

Narcissin (Narcissoside) 是一种黄连糖苷,清除 ONOO 和 SIN-1 衍生的 ONOO, IC50 分别为 3.5 和 9.6 μM。具有抗氧化活性。

Narcissin(Synonyms: 水仙苷; Narcissoside)

Narcissin Chemical Structure

CAS No. : 604-80-8

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5 mg ¥1190 In-stock
10 mg ¥2020 In-stock
20 mg ¥3430 In-stock
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生物活性

Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO and SIN-1-derived ONOO with IC50s of 3.5 and 9.6 μM, respectively[1].

分子量

624.54

Formula

C28H32O16

CAS 号

604-80-8

中文名称

水仙苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (160.12 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6012 mL 8.0059 mL 16.0118 mL
5 mM 0.3202 mL 1.6012 mL 3.2024 mL
10 mM 0.1601 mL 0.8006 mL 1.6012 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.33 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.33 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.33 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.33 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Su BN, et al.  Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity.J Nat Prod. 2005 Apr;68(4):592-5.

Pashanone

天然产物 天然产物苯丙素类 Phenylpropanoids

Pashanone 

Pashanone 是从Lindera erytbrocarpa Makino (Lauraceae) 中分离得到的化合物。

Pashanone

Pashanone Chemical Structure

CAS No. : 42438-78-8

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生物活性

Pashanone is a compound isolated from Lindera erytbrocarpa Makino (Lauraceae)[1].

分子量

300.31

Formula

C17H16O5

CAS 号

42438-78-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ichino K, et al. Synthesis of helilandin B, pashanone, and their isomers. J Nat Prod. 1988;51(5):906-914.

Isoastragaloside IV(Synonyms: 异黄芪皂苷 IV)

天然产物 糖类和糖苷 Saccharides and Glycosides

Isoastragaloside IV;(Synonyms: 异黄芪皂苷 IV) 纯度: ge;99.0%

Isoastragaloside IV 是从黄芪中得到的三萜糖苷类化合物。

Isoastragaloside IV(Synonyms: 异黄芪皂苷 IV)

Isoastragaloside IV Chemical Structure

CAS No. : 136033-55-1

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生物活性

Isoastragaloside IV is a triterpene oligoglycoside isolated from Astragali Radix.

分子量

784.97

Formula

C41H68O14

CAS 号

136033-55-1

中文名称

异黄芪皂苷 IV

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 50 mg/mL (63.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2739 mL 6.3697 mL 12.7393 mL
5 mM 0.2548 mL 1.2739 mL 2.5479 mL
10 mM 0.1274 mL 0.6370 mL 1.2739 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.18 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Cheng X, et al. Astragaloside I Stimulates Osteoblast Differentiation Through the Wnt/β-catenin Signaling Pathway. Phytother Res. 2016 Oct;30(10):1680-1688.

Taspoglutide(Synonyms: ITM077 R1583 BIM51077)

Taspoglutide;(Synonyms: ITM077; R1583; BIM51077) 纯度: 98.21%

Taspoglutide是长效 GLP-1 受体激动剂, EC50值为0.06 nM,可用于 2 型糖尿病的相关研究。

Taspoglutideamp;;(Synonyms: ITM077;  R1583;  BIM51077)

Taspoglutide Chemical Structure

CAS No. : 275371-94-3

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1 mg ¥1100 In-stock
5 mg ¥3300 In-stock
10 mg ¥5000 In-stock
25 mg ¥10000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC50 value of 0.06 nM.

IC50 Target

EC50: 0.06 nM (GLP-1)[1]

体外研究
(In Vitro)

Taspoglutide (R1583/BIM51077) is a long acting 10% formulation of (Aib8-35) human GLP-1 (7-36 amides) with 93% homology with the native polypeptide. It activates the GLP-1 receptor. Taspoglutide has comparable affinity (affinity constant 1.1±0.2 nM) to the natural ligand (affinity constant 1.5±0.3 nM) for the hGLP-1 receptor and exhibits comparable potency in stimulating cAMP production[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Taspoglutide has been shown to enhance the rate of glucose-induced insulin secretion from isolated, cultured rat islets and the perfused ZDF rat pancreas. Taspoglutide in Sprague-Dawley rats and diabetic db/db mice have shown a dose-related enhancement of glucose-dependent insulin release, which lower blood glucose in the db/db mouse model of type 2 diabetes[3]. Acute treatment with taspoglutide reduces glucose excursion and increased insulin response during oGTT. In chronically treated rats, glucose excursion and levels of GIP, PYY and triglycerides during oGTT on day 21 are significantly reduced[4]. Hepatic triglyceride levels are significantly reduced in livers from taspoglutide-treated. Taspoglutide does not reduce plaque area or lipid content in the aortic arch or abdominal aorta, and no significant change in aortic macrophage accumulation is detected after taspoglutide or metformin mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

3339.71

Formula

C152H232N40O45

CAS 号

275371-94-3

Sequence

His-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-{Aib}-Arg-NH2

Sequence Shortening

H-{Aib}-EGTFTSDVSSYLEGQAAKEFIAWLVK-{Aib}-R-NH2

中文名称

他司鲁泰

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : ≥ 28 mg/mL (8.38 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2994 mL 1.4971 mL 2.9943 mL
5 mM 0.0599 mL 0.2994 mL 0.5989 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Sebokova E, et al. Taspoglutide, an analog of human glucagon-like Peptide-1 with enhanced stability and in vivo potency. Endocrinology. 2010 Jun;151(6):2474-82.

    [2]. Retterstol K, et al. Taspoglutide: a long acting human glucagon-like polypeptide-1 analogue. Expert Opin Investig Drugs. 2009 Sep;18(9):1405-11.

    [3]. Nauck MA, et al. Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care. 2009 Jul;32(7):1237-43.

    [4]. Sebokova E, et al. Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat. Diabetes Obes Metab. 2010 Aug;12(8):674-82.

    [5]. Panjwani N, et al. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology. 2013 Jan;154(1):127-39.

Animal Administration
[4][5]

Rats: The Zucker diabetic fatty (ZDF) rats (animal model of type 2 diabetes) are used in the study. ZDF rats are treated acutely (0.1, 1, 10 μg/kg) or chronically (sustained-release of 1 mg) with a single long-acting dose of taspoglutide. Pioglitazone is used as a positive control in the chronic study. Postprandial glucose, body weight, glycaemic control and insulin sensitivity are assessed over 21 days in chronically treated animals[4].

Mice: High-fat diet-fed male ApoE-/- mice are used in the study. Mice with glucose levels from 15-25 mM are then randomized to different groups and treated for 12 wk with a once-monthly sc 0.4-mg taspoglutide microtablet suspension, a sc placebo microtablet, or metformin (400 mg/kg*d) continuously provided in the drinking water plus a sc placebo microtablet[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Sebokova E, et al. Taspoglutide, an analog of human glucagon-like Peptide-1 with enhanced stability and in vivo potency. Endocrinology. 2010 Jun;151(6):2474-82.

    [2]. Retterstol K, et al. Taspoglutide: a long acting human glucagon-like polypeptide-1 analogue. Expert Opin Investig Drugs. 2009 Sep;18(9):1405-11.

    [3]. Nauck MA, et al. Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care. 2009 Jul;32(7):1237-43.

    [4]. Sebokova E, et al. Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat. Diabetes Obes Metab. 2010 Aug;12(8):674-82.

    [5]. Panjwani N, et al. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology. 2013 Jan;154(1):127-39.

S961 TFA

S961 TFA;

S961 TFA 是一种高亲和力的胰岛素受体 (insulin receptor, IR) 拮抗剂,对 HIR-A,HIR-B 和人胰岛素样生长因子 I 受体 (HIGF-IR) 的 IC50 分别为 0.048,0.027 和 630 nM。

S961 TFA 

S961 TFA Chemical Structure

规格 价格 是否有货
1 mg ¥5500 询问价格 & 货期
5 mg ¥15000 询问价格 & 货期
10 mg ¥25000 询问价格 & 货期

* Please select Quantity before adding items.

S961 TFA 的其他形式现货产品:

S961 acetate

生物活性

S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively[1].

体外研究
(In Vitro)

S961 also shows high-affinity to Rat IR and Pig IR with IC50s of 0.056 nM and 0.084 nM in PEG-assay, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4918.15

Formula

C211H297N55O71S2.C2HF3O2

Sequence

Gly-Ser-Leu-Asp-Glu-Ser-Phe-Tyr-Asp-Trp-Phe-Glu-Arg-Gln-Leu-Gly-Gly-Gly-Ser-Gly-Gly-Ser-Ser-Leu-Glu-Glu-Glu-Trp-Ala-Gln-Ile-Gln-Cys-Glu-Val-Trp-Gly-Arg-Gly-Cys-Pro-Ser-Tyr (Disulfide bridge: Cys33-Cys40)

Sequence Shortening

GSLDESFYDWFERQLGGGSGGSSLEEEWAQIQCEVWGRGCPSY (Disulfide bridge: Cys33-Cys40)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

H2O : 6.5 mg/mL (1.32 mM; ultrasonic and adjust pH to 12 with NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2033 mL 1.0166 mL 2.0333 mL
5 mM
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Schäffer L, et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008 Nov 14;376(2):380-3.

Isosinensetin(Synonyms: 异橙黄酮)

天然产物 黄酮类 Flavonoids

Isosinensetin (Synonyms: 异橙黄酮) 纯度: 99.26%

Isosinensetin 是从青皮中提取的一种甲氧基黄酮类化合物, 对 MDR1-MDCKII 细胞中的 p- 糖蛋白 (P-gp) 具有抑制作用。

Isosinensetin(Synonyms: 异橙黄酮)

Isosinensetin Chemical Structure

CAS No. : 17290-70-9

规格 价格 是否有货 数量
5 mg ¥1780 In-stock
10 mg ¥3030 询价
20 mg ¥5140 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Isosinensetin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • Membrane Transporter/Ion Channel Compound Library
  • Natural Product Library
  • Antibacterial Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Food-Sourced Compound Library

生物活性

Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on P-glycoprotein (P-gp) in MDR1-MDCKII cells[1][2].

IC50 & Target

P-glycoprotein[2]

分子量

372.37

Formula

C20H20O7

CAS 号

17290-70-9

中文名称

异橙黄酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 12.5 mg/mL (33.57 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6855 mL 13.4275 mL 26.8550 mL
5 mM 0.5371 mL 2.6855 mL 5.3710 mL
10 mM 0.2686 mL 1.3428 mL 2.6855 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Wang D, et al. Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. J Pharm Biomed Anal. 2007 May 9;44(1):63-9.

    [2]. Bai J, et al. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicol Appl Pharmacol. 2019 Apr 15;369:49-59.

    [3]. Kanda Panthong, et al. Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities. Journal of the Brazilian Chemical Society. Print version ISSN 0103-5053

Soyasaponin Ab(Synonyms: 大豆皂苷Ab)

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin Ab;(Synonyms: 大豆皂苷Ab) 纯度: ge;99.0%

Soyasaponin Ab 是一种大豆皂苷,在 3T3-L1 脂肪细胞中通过下调 PPARγ 产生抗肥胖作用。

Soyasaponin Ab(Synonyms: 大豆皂苷Ab)

Soyasaponin Ab Chemical Structure

CAS No. : 118194-13-1

规格 价格 是否有货 数量
5 mg ¥2020 In-stock
10 mg ¥3430 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Soyasaponin Ab 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Obesity Compound Library
  • Food-Sourced Compound Library

生物活性

Soyasaponin Ab is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ)[1].

分子量

1437.52

Formula

C67H104O33

CAS 号

118194-13-1

中文名称

大豆皂苷Ab

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (69.56 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6956 mL 3.4782 mL 6.9564 mL
5 mM 0.1391 mL 0.6956 mL 1.3913 mL
10 mM 0.0696 mL 0.3478 mL 0.6956 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.74 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.74 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.74 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.74 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Yang SH, et al. Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ. Phytother Res. 2015 Feb;29(2):281-7.