Gluten Exorphin C

Gluten Exorphin C; 纯度: 98.97%

Gluten exorphin C 是一种源自谷朊粉的阿片肽。在 GPI 和 MVD 检测中,抑制 μ opioidδ opioid 活性,IC50 值分别为 40 μM 和13.5 μM。

Gluten Exorphin Camp;;

Gluten Exorphin C Chemical Structure

CAS No. : 142479-62-7

规格 价格 是否有货 数量
1 mg ¥1100 In-stock
5 mg ¥1900 In-stock
10 mg ¥2900 In-stock
25 mg ¥5900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Gluten Exorphin C 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Neurotransmitter Receptor Compound Library
  • Anti-Obesity Compound Library
  • Peptide Library

生物活性

Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

IC50 Target

IC50: 40 μM (μ opioid), 13.5 μM (δ opioid)[1]

体外研究
(In Vitro)

Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC50s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

591.70

Formula

C29H45N5O8

CAS 号

142479-62-7

Sequence

Tyr-Pro-Ile-Ser-Leu

Sequence Shortening

YPISL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (169.00 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6900 mL 8.4502 mL 16.9005 mL
5 mM 0.3380 mL 1.6900 mL 3.3801 mL
10 mM 0.1690 mL 0.8450 mL 1.6900 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Fukudome S, et al. Gluten exorphin C. A novel opioid peptide derived from wheat gluten. FEBS Lett. 1993 Jan 18;316(1):17-9.

Dipsanoside B(Synonyms: 续断苷 B)

天然产物 糖类和糖苷 Saccharides and Glycosides

Dipsanoside B;(Synonyms: 续断苷 B)

Dipsanoside B 是一种来自川续断 (Dipsacus asper) 的新型四环苷类葡萄糖苷。川续断是一种在中国广泛存在的多年生植物,被用于传统中药中已有数百年,可以作为补品,作为骨质细胞的分裂促进剂,以及胚胎安全剂等。

Dipsanoside B(Synonyms: 续断苷 B)

Dipsanoside B Chemical Structure

CAS No. : 889678-64-2

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc[1].

分子量

1475.40

Formula

C66H90O37

CAS 号

889678-64-2

中文名称

续断苷 B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tian, X.-Y. et al. Two Novel Tetrairidoid Glucosides from Dipsacus asper. Organic Letters, 2006,8(10), 2179–2182.

TRV120056

TRV120056;

TRV120056 是一种偏向 Gq 的激动剂,在 AT1R-Gq 融合蛋白上的分子效率是 AT1R-βarr2 融合蛋白的 10 倍。

TRV120056amp;;

TRV120056 Chemical Structure

CAS No. : 40678-47-5

规格 价格 是否有货 数量
1 mg ¥500 In-stock
5 mg ¥900 In-stock
10 mg ¥1500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

TRV120056 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

分子量

956.06

Formula

C43H65N13O12

CAS 号

40678-47-5

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Gly

Sequence Shortening

DRVYIHPG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 33.33 mg/mL (34.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0460 mL 5.2298 mL 10.4596 mL
5 mM 0.2092 mL 1.0460 mL 2.0919 mL
10 mM 0.1046 mL 0.5230 mL 1.0460 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77.

    [2]. Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24.

OJV-VI

天然产物 糖类和糖苷 Saccharides and Glycosides

OJV-VI;

OJV-VI 是存在于麦冬属植物中的天然产物。

OJV-VI

OJV-VI Chemical Structure

CAS No. : 125150-67-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

OJV-VI is found in ophiopogonis[1].

分子量

855.02

Formula

C44H70O16

CAS 号

125150-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Asano T, Murayama T, Hirai Y, Shoji J. Comparative studies on the constituents of ophiopogonis tuber and its congeners. VIII. Studies on the glycosides of the subterranean part of Ophiopogon japonicus Ker-Gawler cv. Nanus. Chem Pharm Bull (Tokyo). 1993;41

Arg-Gly-Asp-Cys TFA

Arg-Gly-Asp-Cys TFA;

Arg-Gly-Asp-Cys TFA 是纤维粘连蛋白与细胞粘附分子的结合基序,能够抑制血小板凝集以及纤维蛋白原结合。

Arg-Gly-Asp-Cys TFAamp;;

Arg-Gly-Asp-Cys TFA Chemical Structure

CAS No. : 2171504-22-4

规格 价格 是否有货 数量
5 mg ¥770 In-stock
10 mg ¥1250 In-stock
25 mg ¥2500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Arg-Gly-Asp-Cys TFA 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Covalent Screening Library
  • Anti-Cardiovascular Disease Compound Library
  • Peptide Library

生物活性

Arg-Gly-Asp-Cys TFA is the binding motif of fibronectin to cell adhesion molecules. Arg-Gly-Asp-Cys TFA can inhibit platelet aggregation and fibrinogen binding[1].

体外研究
(In Vitro)

Arg-Gly-Asp-Cys-functionalized chitosan (0.25-1 mg/mL; 2-7 days) favors cell growth and an increase in cellular proliferation compared to the control cells (viability >140%)[1].
Arg-Gly-Asp-Cys-functionalizes chitosan derivatives exhibit in vitro wound healing properties by enhancing fibroblast proliferation and adhesion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

563.51

Formula

C17H28F3N7O9S

CAS 号

2171504-22-4

Sequence Shortening

RGDC

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro:;

H2O : 250 mg/mL (443.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7746 mL 8.8730 mL 17.7459 mL
5 mM 0.3549 mL 1.7746 mL 3.5492 mL
10 mM 0.1775 mL 0.8873 mL 1.7746 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Patrulea V, et, al. Peptide-decorated chitosan derivatives enhance fibroblast adhesion and proliferation in wound healing. Carbohydr Polym. 2016 May 20;142:114-23.

LRGILS-NH2 TFA

LRGILS-NH2 TFA; 纯度: 98.15%

LRGILS-NH2 TFA 是一个反向序列蛋白酶激活受体-2 (PAR-2) 不活跃的,阴性对照。SLIGRL-NH2 则是 PAR-2 激活肽。

LRGILS-NH2 TFAamp;;

LRGILS-NH2 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥600 In-stock
5 mg ¥1800 In-stock
10 mg ¥2900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

LRGILS-NH2 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

LRGILS-NH2 TFA is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide[1].

分子量

770.84

Formula

C31H57F3N10O9

Sequence Shortening

LRGILS-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL (129.73 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2973 mL 6.4864 mL 12.9729 mL
5 mM 0.2595 mL 1.2973 mL 2.5946 mL
10 mM 0.1297 mL 0.6486 mL 1.2973 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.24 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Nishikawa H, Kawai K, Tanaka M, et al. Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms. J Pharmacol Exp Ther. 2005;312(1):324-331.

Gentianose

天然产物 糖类和糖苷 Saccharides and Glycosides

Gentianose;

Gentianose 是多年生黄龙胆贮藏根中主要的碳水化合储备物。

Gentianose

Gentianose Chemical Structure

CAS No. : 25954-44-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Gentianose is a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea[1].

分子量

504.44

Formula

C18H32O16

CAS 号

25954-44-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Imperio D, et al. Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds. Food Chem. 2021;344:128588.

Eupteleasaponin I

天然产物 糖类和糖苷 Saccharides and Glycosides

Eupteleasaponin I;

Eupteleasaponin I 是多花领春木中的成分,可能具有胃保护功能。

Eupteleasaponin I

Eupteleasaponin I Chemical Structure

CAS No. : 290809-29-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Eupteleasaponin I is a component of Euptelea polyandra, may has gastroprotective activity[1].

分子量

1043.19

Formula

C52H82O21

CAS 号

290809-29-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yoshikawa M, et al. Bioactive saponins and glycosides. XVI. Nortriterpene oligoglycosides with gastroprotective activity from the fresh leaves of Euptelea polyandra Sieb. et Zucc. (1): structures of Eupteleasaponins I, II, III, IV, V, and V acetate. Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1045-50.

HAEGT

HAEGT; 纯度: 99.26%

HAEGT 是胰高血糖素样肽-1 (GLP-1) 的多肽 N-端的 1-5 残基片段。HAEGT 可作为竞争性底物,检测人二肽基肽-IV (DPP-IV) 的底物结合位点。

HAEGTamp;;

HAEGT Chemical Structure

CAS No. : 852155-81-8

规格 价格 是否有货 数量
1 mg ¥1600 In-stock
5 mg ¥4800 In-stock
10 mg ¥6800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

HAEGT 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide. HAEGT can acts as competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV[1].

分子量

513.50

Formula

C20H31N7O9

CAS 号

852155-81-8

Sequence

His-Ala-Glu-Gly-Thr

Sequence Shortening

HAEGT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Lisa M. Kopcho, et al. Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach. Archives of Biochemistry and Biophysics 436 (2005) 367–376.

VKGILS-NH2

VKGILS-NH2; 纯度: 99.68%

VKGILS-NH2 是一种 SLIGKV-NH2 (蛋白酶激活的受体 2 (PAR2) 的激动剂) 的反向氨基酸序列对照肽,对细胞中的 DNA 合成没有影响。

VKGILS-NH2amp;;

VKGILS-NH2 Chemical Structure

CAS No. : 942413-05-0

规格 价格 是否有货 数量
5 mg ¥1200 In-stock
10 mg ¥2000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

VKGILS-NH2 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Immunology/Inflammation Compound Library
  • Peptide Library

生物活性

VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells[1][2].

分子量

614.78

Formula

C28H54N8O7

CAS 号

942413-05-0

Sequence

Val-Lys-Gly-Ile-Leu-Ser-NH2

Sequence Shortening

VKGILS-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (162.66 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6266 mL 8.1330 mL 16.2660 mL
5 mM 0.3253 mL 1.6266 mL 3.2532 mL
10 mM 0.1627 mL 0.8133 mL 1.6266 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.07 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. M Tognetto, et al. Evidence That PAR-1 and PAR-2 Mediate Prostanoid-Dependent Contraction in Isolated Guinea-Pig Gallbladder. Br J Pharmacol. 2000 Oct;131(4):689-94.

    [2]. David A Vesey, et al. Proinflammatory and Proliferative Responses of Human Proximal Tubule Cells to PAR-2 Activation. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1441-9.