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Rosthornin A(Synonyms: (-)-Rosthornin A; Isodopharicin C)

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Rosthornin A (Synonyms: (-)-Rosthornin A; Isodopharicin C)

Rosthornin A 是一种 ent-kaurene diterpenoid 化合物，从 Rabdosia rosthornii 干叶的醚提取物中分离得到。

Rosthornin A(Synonyms: (-)-Rosthornin A; Isodopharicin C)

Rosthornin A Chemical Structure

CAS No. : 125164-55-8

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生物活性

Rosthornin A is a ent-kaurene diterpenoid compound, isolated from the ether extract of the dried leaves of Rabdosia rosthornii[1].

分子量

376.49

Formula

C22H32O5
CAS 号

125164-55-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kubo I, et al. Antibacterial activity of ent-kaurene diterpenoids from Rabdosia rosthornii. Phytother Res. 2004;18(2):180-183.

Huzhangoside D

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Huzhangoside D 

Huzhangoside D 是从铁线莲的根和根茎中分离得到的皂苷类化合物。

Huzhangoside D

Huzhangoside D Chemical Structure

CAS No. : 96315-53-6

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生物活性

Huzhangoside D is a saponin compound isolated from the roots and rhizomes of Clematis graveolens[1].

分子量

1353.49

Formula

C64H104O30
CAS 号

96315-53-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rattan R, et al. Triterpenoid Saponins from Clematis graveolens and Evaluation of their Insecticidal Activities. Nat Prod Commun. 2015;10(9):1525-1528.

Glychionide A(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Glychionide A;(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A 是一种黄酮苷，存在于 Glychirriza glabra 的根中。Glychionide A 促进 PANC-1 胰腺癌细胞的凋亡和自噬。Glychionide A 可用于癌症的研究。

Glychionide A(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A Chemical Structure

CAS No. : 119152-50-0

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生物活性

Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].

体外研究
(In Vitro)

Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM[1].
Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

446.36

Formula

C21H18O11
CAS 号

119152-50-0
中文名称

去甲汉黄芩素-7-O-葡萄糖醛酸苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.

    [2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb 3;25:962-969.

Uty HY Peptide (246-254) (TFA)

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Uty HY Peptide (246-254) (TFA); 纯度: 99.93%

Uty HY Peptide (246-254) TFA，一种 H-Y 表位 H-YDb，来源于 UTY 蛋白，可作为男性特异性移植抗原 H-Y。

Uty HY Peptide (246-254) (TFA)amp;;

Uty HY Peptide (246-254) (TFA) Chemical Structure

规格 价格 是否有货 数量
5 mg ￥800 In-stock
10 mg ￥1100 In-stock
25 mg ￥2000 In-stock
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Uty HY Peptide (246-254) (TFA) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Peptide Library

生物活性

Uty HY Peptide (246-254) TFA, derived from the ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome (UTY) protein as an H-Y epitope, H-YDb, is a male-specific transplantation antigen H-Y[1].

分子量

1310.42

Formula

C55H78F3N15O15S2
Sequence Shortening

WMHHNMDLI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 12.5 mg/mL (9.54 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7631 mL 3.8156 mL 7.6311 mL
5 mM 0.1526 mL 0.7631 mL 1.5262 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Greenfield A, et al. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Nat Genet. 1996;14(4):474-478.

Kansuinine B(Synonyms: 甘遂萜酯B)

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Kansuinine B (Synonyms: 甘遂萜酯B)

Kansuinine B 抑制IL-6 诱导的激活。Kansuinine B 具有抗病毒活性，可用于COVID-19的研究。

Kansuinine B(Synonyms: 甘遂萜酯B)

Kansuinine B Chemical Structure

CAS No. : 57685-46-8

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生物活性

Kansuinine B inhibits IL-6-induced Stat3 activation. Kansuinine B possesses anti-viral activity and could be used in the study for COVID-19[1][2][3].

分子量

722.73

Formula

C38H42O14
CAS 号

57685-46-8
中文名称

甘遂萜酯B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jong Sun Chang, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010 Oct;76(14):1544-9.

    [2]. Xiaoyun Shu, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. J Nat Med. 2010 Jan;64(1):98-103.

    [3]. YASER DAANIAL , et al. PROMISING COMPOUNDS FOR TREATMENT OF COVID-19. VAWKUM Transactions on Computer Sciences, ISSN(e):2308-8168, ISSN(p): 2411-6335. Volume 17, Number 1, January-June, 2020.

Mini Gastrin I, human TFA

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Mini Gastrin I, human TFA; 纯度: 98.08%

Mini Gastrin I, human (TFA) 为由 13 个氨基酸组成的短的人胃泌素 (gastrin)。

Mini Gastrin I, human TFAamp;;

Mini Gastrin I, human TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥7500 In-stock
10 mg ￥12000 In-stock
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Mini Gastrin I, human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.

分子量

1760.75

Formula

C76H100F3N15O28S
Sequence

Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Sequence Shortening

LEEEEEAYGWMDF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Behr TM, et al. Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors. J Nucl Med. 1999 Jun;40(6):1029-44.

Ilexhainanoside D(Synonyms: 海南冬青苷D)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ilexhainanoside D (Synonyms: 海南冬青苷D)

Ilexhainanoside D 是从 Ilex hainanensis Merr. 中提取的主要三萜皂苷，Ilexhainanoside D 和 Ilexsaponin A1 联合使用后具有抗炎的作用。

Ilexhainanoside D(Synonyms: 海南冬青苷D)

Ilexhainanoside D Chemical Structure

CAS No. : 1137648-52-2

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生物活性

Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect[1].

体内研究
(In Vivo)

The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240 mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

664.82

Formula

C36H56O11
CAS 号

1137648-52-2
中文名称

海南冬青苷D
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhao W, et al. The combination of Ilexhainanoside D and ilexsaponin A1 reduces liver inflammation and improves intestinal barrier function in mice with high-fat diet-induced non-alcoholic fatty liver disease. Phytomedicine. 2019 Jul 26;63:153039.

Sutchuenmedin A

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Sutchuenmedin A;

Sutchuenmedin A 是一种 prenylflavonoid。Sutchuenmedin A 从四川淫羊藿 70% 乙醇提取物中分离得到。

Sutchuenmedin A

Sutchuenmedin A Chemical Structure

CAS No. : 1197194-31-2

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生物活性

Sutchuenmedin A is a prenylflavonoid. Sutchuenmedin A is isolated from the 70% EtOH extract of Epimedium sutchuenense[1].

分子量

658.65

Formula

C33H38O14
CAS 号

1197194-31-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yu, C. Y., et al. Two new prenylflavonoids from Epimedium sutchuenense. Chinese Chemical Letters, 20(7), 842–844.

Harringtonolide

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Harringtonolide 

Harringtonolide 是一种有效的 RACK1 抑制剂，在 A375 细胞中 IC50=39.66 μM。Harringtonolide 通过影响 FAK 和 RACK1 的相互作用来抑制上皮-间充质转化 (EMT) 过程和细胞增殖。Harringtonolide 具有抑制植物生长、抗病毒、抗炎、抗增殖活性。

Harringtonolide

Harringtonolide Chemical Structure

CAS No. : 64761-48-4

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生物活性

Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1].

IC50 & Target

IC50: 39.66 μM (RACK1) in A375 cells[1]
体外研究
(In Vitro)

Harringtonolide (0-50 μM; 24 hours) exhibits good antiproliferation activity in A375 cells with IC50 of 39.66 μM[1].
Harringtonolide (0-20 μM; 1 hour) restrains the proteolysis of RACK1 by Pronase, and protects temperature-dependent degradation of RACK1[1].
Harringtonolide (0-4 μM; 24 hours) suppresses the phosphorylation of FAK dose-dependently and inhibits Src and STAT3, the downstream proteins of FAK[1].
Harringtonolide (0-4 μM; 24 hours) dose-dependently inhibits the RACK1–FAK interaction in A375 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: A375 melanoma cells[1]
Concentration: 0-50 μM
Incubation Time: 24 hours
Result: Showed good antiproliferation activity with IC50 of 39.66 μM.

Western Blot Analysis

Cell Line: A375 melanoma cells[1]
Concentration: 0, 0.5, 1, 2, 4 μM
Incubation Time: 24 hours
Result: Suppressed the phosphorylation of FAK dose-dependently and inhibited Src and STAT3, the downstream proteins of FAK.

分子量

310.34

Formula

C19H18O4
CAS 号

64761-48-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhu TY, et al. Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition. ACS Med Chem Lett. 2022;13(3):449-456. Published 2022 Feb 2.

Licoricesaponin G2(Synonyms: 甘草皂苷G2)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Licoricesaponin G2;(Synonyms: 甘草皂苷G2)

Licoricesaponin G2 是一种从 Glycyrrhiza aspera 中分离的五环三萜类化合物。

Licoricesaponin G2(Synonyms: 甘草皂苷G2)

Licoricesaponin G2 Chemical Structure

CAS No. : 118441-84-2

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生物活性

Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera[1].

分子量

838.93

Formula

C42H62O17
CAS 号

118441-84-2
中文名称

甘草皂苷G2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Inami K, et al. Antimutagenic components in Glycyrrhiza against N-methyl-N-nitrosourea in the Ames assay. Nat Prod Res. 2017 Mar;31(6):691-695.